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公开(公告)号:US10106529B2
公开(公告)日:2018-10-23
申请号:US15161114
申请日:2016-05-20
申请人: CalciMedica, Inc.
发明人: Jeffrey P. Whitten , Jonathan Grey , Jianguo Cao , Zhijun Wang , Evan Rogers
IPC分类号: C07D405/04 , C07D417/04 , C07D401/12 , C07D403/04 , C07D401/04 , C07D239/47 , C07D213/74 , C07D491/056 , C07D491/04 , C07D405/10 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/506 , C07D401/14
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号:US09512116B2
公开(公告)日:2016-12-06
申请号:US14432959
申请日:2013-10-11
申请人: CALCIMEDICA, INC.
发明人: Evan Rogers , Jianguo Cao , Zhijun Wang , Jonathan Grey , Jeffrey P. Whitten
IPC分类号: C07D417/14 , C07D409/04 , C07D409/14 , A61K31/4155 , C07D413/04
CPC分类号: C07D417/14 , A61K31/4155 , C07D409/04 , C07D409/14 , C07D413/04
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号:US09353099B2
公开(公告)日:2016-05-31
申请号:US14742556
申请日:2015-06-17
申请人: CalciMedica, Inc.
发明人: Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号: C07D221/02 , A61K31/44 , C07D417/12 , C07C233/75 , C07C233/80 , C07C255/60 , C07D231/16 , C07D231/12 , C07D231/14 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07C233/92 , C07D213/81 , C07D231/18 , C07D231/56 , C07D263/57 , C07D277/34 , C07D277/56 , C07D317/62 , C07D333/38 , C07D471/04
CPC分类号: C07D417/12 , C07C233/75 , C07C233/80 , C07C233/92 , C07C255/60 , C07C2601/02 , C07D213/81 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/56 , C07D263/57 , C07D277/34 , C07D277/56 , C07D317/62 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号:US20140256745A1
公开(公告)日:2014-09-11
申请号:US14353285
申请日:2012-10-19
申请人: CalciMedica, Inc.
发明人: Jianguo Cao , Jeffrey P. Whitten , Zhijun Wang , Evan Rogers , Jonathan Grey
IPC分类号: C07D405/14 , C07D417/14 , C07D413/14
CPC分类号: C07D405/14 , C07D277/54 , C07D413/14 , C07D417/14
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号:US20130231344A1
公开(公告)日:2013-09-05
申请号:US13734087
申请日:2013-01-04
申请人: CALCIMEDICA, INC.
发明人: Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号: C07D409/04 , C07D417/04 , C07D471/04 , C07D413/14 , C07D417/14 , C07D409/14 , C07D333/38
CPC分类号: C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号:US09090612B2
公开(公告)日:2015-07-28
申请号:US14267759
申请日:2014-05-01
申请人: CalciMedica, Inc.
发明人: Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号: C07D221/02 , C07D471/04 , C07C233/75 , C07C233/80 , C07C255/60 , C07D231/16 , C07D231/12 , C07D231/14 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07C233/92 , C07D213/81 , C07D231/18 , C07D231/56 , C07D263/57 , C07D277/34 , C07D277/56 , C07D317/62 , C07D333/38
CPC分类号: C07D417/12 , C07C233/75 , C07C233/80 , C07C233/92 , C07C255/60 , C07C2601/02 , C07D213/81 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/56 , C07D263/57 , C07D277/34 , C07D277/56 , C07D317/62 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译: 本文描述了含有这种化合物的化合物和药物组合物,其调节储存操作的钙(SOC)通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号:US08980629B2
公开(公告)日:2015-03-17
申请号:US13975238
申请日:2013-08-23
申请人: CalciMedica, Inc.
发明人: Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号: C07D213/75 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D471/04 , C07D493/10 , C07D409/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04
CPC分类号: C07D213/74 , C07D213/75 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D493/10 , C07D495/04
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号:US20140243366A1
公开(公告)日:2014-08-28
申请号:US14267759
申请日:2014-05-01
申请人: CalciMedica, Inc.
发明人: Jeffrey P. WHITTEN , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号: C07D471/04 , C07D401/12 , C07D213/81 , C07D417/12 , C07D413/04 , C07D277/34 , C07D231/56 , C07D405/12 , C07D231/18 , C07D333/38 , C07D317/62 , C07C233/92 , C07D277/56 , C07D417/14 , C07D409/14 , C07D263/57 , C07D413/14
CPC分类号: C07D417/12 , C07C233/75 , C07C233/80 , C07C233/92 , C07C255/60 , C07C2601/02 , C07D213/81 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/56 , C07D263/57 , C07D277/34 , C07D277/56 , C07D317/62 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号:US20130245063A1
公开(公告)日:2013-09-19
申请号:US13871844
申请日:2013-04-26
申请人: CALCIMEDICA, INC.
发明人: Jeffrey P. Whitten , Jonathan Grey , Jianguo Cao , Zhijun Wang , Evan Rogers
IPC分类号: C07D405/10 , C07D213/74 , C07D401/04 , C07D417/04 , C07D491/056
CPC分类号: C07D405/04 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/506 , C07D213/74 , C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/10 , C07D417/04 , C07D491/04 , C07D491/056
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号:US10336738B2
公开(公告)日:2019-07-02
申请号:US14730119
申请日:2015-06-03
申请人: CalciMedica Inc.
发明人: Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号: C07D413/04 , A61K9/00 , A61K9/02 , A61K9/48 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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