公开(公告)号：US20230158171A1

公开(公告)日：2023-05-25

申请号：US17850879

申请日：2022-06-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mikhail SHAPIRO ,  Jerzy O. SZABLOWSKI

IPC: A61K48/00 ,  A61P21/00 ,  C12N15/113 ,  A61M37/00 ,  A61N7/00 ,  A61K38/17 ,  A61K9/00

CPC classification number: A61K48/0058 ,  A61P21/00 ,  C12N15/113 ,  A61K48/0016 ,  A61K48/0025 ,  A61K48/0066 ,  A61K48/0083 ,  A61M37/00 ,  A61N7/00 ,  A61K38/1709 ,  A61K9/0019 ,  A61K48/0075 ,  A61N2007/003 ,  A61N2007/0039 ,  A61N2007/0021

Abstract: Provided herein are methods, systems, and related vectors and compositions allowing for noninvasive control of neural circuits. In particular, the methods and systems herein described utilize acoustically targeted chemogenetics to achieve a noninvasive neuromodulation in specifically selected cell-types among spatially selected brain regions.

公开(公告)号：US20150153319A1

公开(公告)日：2015-06-04

申请号：US14561114

申请日：2014-12-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mikhail SHAPIRO ,  Azita EMAMI ,  Manuel Alejandro MONGE OSORIO

IPC: G01N33/483 ,  H04B1/40 ,  A61B5/07 ,  G01S17/00 ,  G01R33/07

CPC classification number: G01N33/483 ,  A61B5/0522 ,  A61B5/073 ,  G01R33/077 ,  G01R33/1269 ,  G01R33/1284 ,  H04B1/40

Abstract: Methods and apparatuses for sensing biological functions are disclosed. Sensors can be implanted in an organ, such as the brain, and a magnetic field gradient applied to the biological tissue. The field causes the sensors to have different resonant frequencies allowing their spatial localization. The sensors can harvest power from the external coils to be able to retransmit data.

Abstract translation: 公开了用于感测生物功能的方法和装置。 可以将传感器植入诸如脑的器官，以及施加到生物组织的磁场梯度。 该场导致传感器具有不同的谐振频率，从而允许其空间定位。 传感器可以从外部线圈获取电力，以便能够重新发送数据。

公开(公告)号：US20200291409A1

公开(公告)日：2020-09-17

申请号：US16736683

申请日：2020-01-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Arash FARHADI ,  Gabrielle H HO ,  Daniel P SAWYER ,  Mikhail SHAPIRO

IPC: C12N15/67 ,  C07K14/195

Abstract: Provided herein are genetically engineered gas vesicle expression systems (GVES) that are configured to express gas vesicles (GVs) in a mammalian cell, related gas vesicle polynucleotide constructs, gas vesicle reporting genetic circuits, vectors, genetically engineered mammalian cells, non-human mammalian hosts, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging techniques to detect and report biological events in an imaging target site comprising a mammalian cell and/or organism.

公开(公告)号：US20190388105A1

公开(公告)日：2019-12-26

申请号：US16409727

申请日：2019-05-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Saransh SHARMA ,  Abhinav AGARWAL ,  Mikhail SHAPIRO ,  Azita EMAMI

IPC: A61B17/17

Abstract: A three dimensional magnetic sensor attached to a surgical nail is located based on an applied monotonic magnetic field gradient. Another three dimensional magnetic sensor locates a surgical drill. A display generates a real time image of the relative alignment of the surgical drill and of the surgical nail, allowing a surgeon to repair bone fractures.

公开(公告)号：US20180028693A1

公开(公告)日：2018-02-01

申请号：US15613104

申请日：2017-06-02

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anupama LAKSHMANAN ,  Arash FARHADI ,  Suchita P. NETY ,  Raymond W. BOURDEAU ,  Mikhail SHAPIRO

IPC: A61K49/22 ,  A61B8/08

CPC classification number: A61K49/223 ,  A61B8/481 ,  A61B8/5238 ,  A61K49/0002 ,  A61K49/0045 ,  A61K49/0093 ,  A61K49/221 ,  C07K14/195 ,  C07K2319/00

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

公开(公告)号：US20210060185A1

公开(公告)日：2021-03-04

申请号：US17006591

申请日：2020-08-28

Applicant: California Institute of Technology

Inventor： Anupama LAKSHMANAN ,  Mikhail SHAPIRO ,  Suchita P. NETY ,  Zhiyang JIN

IPC: A61K49/22 ,  C07K14/195 ,  C12Q1/37

Abstract: Provided herein are engineered protease sensitive gas vesicles and related engineered protease genetically GvpC constructs, vectors, gas vesicles gene clusters, genetic circuits, cells, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging technique, to detect and report protease activity and related biological events in an imaging target site.

公开(公告)号：US20210040161A1

公开(公告)日：2021-02-11

申请号：US16927590

申请日：2020-07-13

Applicant: California Institute of Technology

Inventor： Dan I. PIRANER ,  Mikhail SHAPIRO

IPC: C07K14/255

Abstract: Provided herein are thermomer monomer, thermomer dimers, thermomer monomeric constructs, thermomer dimeric complexes, and related gene expression cassette vectors, cells, surfaces devices, compositions methods and systems, that provide a thermobioswitch suitable to control location and/or binding of cargo moiety of interest in a temperature regulated manner.

公开(公告)号：US20200237346A1

公开(公告)日：2020-07-30

申请号：US16736581

申请日：2020-01-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Daniel P. SAWYER ,  Arash FARHADI ,  Avinoam D. BAR-ZION ,  Mikhail SHAPIRO

IPC: A61B8/08

Abstract: The application of a step function increase in acoustic pressure during ultrasound imaging using gas vesicle contrast, along with capturing successive frames of ultrasound imaging and extracting time-series vectors for pixels of the frames, allows for improved imaging down to even the cell level. Template vectors can be used to implement signal separation of the time-series vectors to improve detection.

公开(公告)号：US20200164095A1

公开(公告)日：2020-05-28

申请号：US16656417

申请日：2019-10-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anupama LAKSHMANAN ,  Arash FARHADI ,  Suchita P. NETY ,  Raymond W. BOURDEAU ,  Mikhail SHAPIRO

IPC: A61K49/22 ,  A61K49/00 ,  C07K14/195 ,  A61B8/08

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

公开(公告)号：US20180164276A1

公开(公告)日：2018-06-14

申请号：US15882281

申请日：2018-01-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mikhail SHAPIRO ,  Azita EMAMI ,  Manuel Alejandro MONGE OSORIO

IPC: G01N33/483 ,  A61B5/05 ,  G01R33/12

CPC classification number: G01N33/483 ,  A61B5/0522 ,  A61B5/073 ,  G01R33/077 ,  G01R33/1269 ,  G01R33/1284 ,  H04B1/40

Abstract: Methods and apparatuses for sensing biological functions are disclosed. Sensors can be implanted in an organ, such as the brain, and a magnetic field gradient applied to the biological tissue. The field causes the sensors to have different resonant frequencies allowing their spatial localization. The sensors can harvest power from the external coils to be able to retransmit data.