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公开(公告)号：US11701504B2
公开(公告)日：2023-07-18
申请号：US17150986
申请日：2021-01-15
发明人： Yu-Chong Tai , Aubrey M. Shapero , Shane S. Shahrestani , Azita Emami , Abhinav Agarwal , Kuang-Ming Shang , Sunghoon Kim , Olajire Idowu , Kurtis I. Auguste
IPC分类号： A61M27/00
CPC分类号： A61M27/006 , A61M2205/3344 , A61M2205/3368 , A61M2205/3523 , A61M2205/50 , A61M2207/00
摘要： A long-lasting, wireless, biocompatible pressure sensor device is integrated within a hydrocephalus shunt, either within the shunt's reservoir/anchor or as an inline or pigtailed connector. When integrated within a typical reservoir, the device can sit within the reservoir's hollow frustum area covered by the resilient silicone dome of the reservoir. When integrated as an inline connector, the device can sit at any point on the peritoneal catheter or ventricular catheter, including between the VP shut's valve and reservoir. The pressure sensor device includes electronics that can be powered wirelessly by a reader held to a patient's scalp, and so no battery may be required. The reader can transmit an ambient, atmospheric pressure reading from outside the skull to the implanted device so that its electronics can calculate a calibrated gauge pressure internally and then relay it to a patient's smart phone.
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公开(公告)号：US20210220627A1
公开(公告)日：2021-07-22
申请号：US17150986
申请日：2021-01-15
发明人： Yu-Chong Tai , Aubrey M. Shapero , Shane S. Shahrestani , Azita Emami , Abhinav Agarwal , Kuang-Ming Shang , Sunghoon Kim , Olajire Idowu , Kurtis I. Auguste
IPC分类号： A61M27/00
摘要： A long-lasting, wireless, biocompatible pressure sensor device is integrated within a hydrocephalus shunt, either within the shunt's reservoir/anchor or as an inline or pigtailed connector. When integrated within a typical reservoir, the device can sit within the reservoir's hollow frustum area covered by the resilient silicone dome of the reservoir. When integrated as an inline connector, the device can sit at any point on the peritoneal catheter or ventricular catheter, including between the VP shut's valve and reservoir. The pressure sensor device includes electronics that can be powered wirelessly by a reader held to a patient's scalp, and so no battery may be required. The reader can transmit an ambient, atmospheric pressure reading from outside the skull to the implanted device so that its electronics can calculate a calibrated gauge pressure internally and then relay it to a patient's smart phone.
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公开(公告)号：US20230166004A1
公开(公告)日：2023-06-01
申请号：US18070334
申请日：2022-11-28
发明人： Yu-Chong Tai , Kuang-Ming Shang , Hirotake Komatsu
CPC分类号： A61L27/3804 , C12N5/0068 , A61L27/56 , A61L27/54 , C12N2533/30 , C12N2535/10
摘要： A two-dimensional lattice or mesh scaffold for therapeutic cell implants is disclosed as well as methods for manufacture and use. The lattice is constructed of crisscrossing capillaries of hydrophobic parylene, such as parylene AF4, that may be coated with a hydrophilic polymer, such as parylene C, for cell adhesion. At each intersection of the crisscross, the intersecting capillaries are internally connected so as to allow oxygen to flow freely within. The walls of the capillaries are thin enough to be permeable to oxygen, on the scale of a micron thick, so that oxygen can flow through the lattice and permeate through the capillary walls. For some implants, cells are sandwiched between two or more lattices, the cells being slightly held apart from aggregation with each other by the lattice holes. The implants may then be surgically implanted within a subject.
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公开(公告)号：US20240110068A1
公开(公告)日：2024-04-04
申请号：US18479286
申请日：2023-10-02
发明人： Yu-Chong Tai , Kuang-Ming Shang , Haixu Shen , Ningxuan Dai , David Q. Kong
IPC分类号： C09D5/16 , B05D1/00 , B05D3/02 , B05D3/14 , C09D5/08 , C09D125/02 , C09D191/00
CPC分类号： C09D5/1681 , B05D1/60 , B05D3/0218 , B05D3/148 , C09D5/086 , C09D125/02 , C09D191/00 , B05D2350/60 , B05D2507/00
摘要： A thin oil film having parylene irregular dendritic-like columns extending from one side to another exhibits hydrophobic properties that can be used as a corrosion resistant coating or water-repellant, biofouling resistant surface. This parylene-in-oil layer can be paired with an adjacent layer of solid parylene that it overlays or underlays. The solid parylene cross polymerizes with the parylene dendrites, keeping them in place as well as the oil film. The parylene dendrites are fabricated by chemical vapor deposition (CVD) of parylene over the oil layer, the dendrites self-forming from the bottom to the top. Continued CVD over the dendrites can produce a top layer of solid parylene. Etching the solid parylene away can result in a water repellant, anti-biofouling surface.
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公开(公告)号：US20210283308A1
公开(公告)日：2021-09-16
申请号：US17199844
申请日：2021-03-12
摘要： An oxygen transporter device configured to transport O2 from an ambient air location into or toward a subcutaneous site. The device includes an absorption component, a cannula, and a discharge component configured to be implanted in a subcutaneous location while the absorption component is not subcutaneous. The cannula can extend through or across the skin of a patient. The discharge component can includes one or more multi-layered, flexible mesh sheets, which are coupled to cells.
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