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公开(公告)号：US20050208585A1
公开(公告)日：2005-09-22
申请号：US10778394
申请日：2004-02-17
申请人： Camellia Adams , Paul Carter , Brian Fendly , Austin Gurney
发明人： Camellia Adams , Paul Carter , Brian Fendly , Austin Gurney
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2866 , C07K16/40 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/74 , C07K2317/75 , C07K2317/92
摘要： Various forms of c-mpl agonist antibodies are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.
摘要翻译： 显示各种形式的c-mpl激动剂抗体影响血细胞，特别是巨核细胞和巨核细胞祖细胞的复制，分化或成熟。 因此，这些化合物可用于治疗血小板减少症。
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公开(公告)号：US20060177441A1
公开(公告)日：2006-08-10
申请号：US11402010
申请日：2006-04-12
申请人： Camellia Adams , Austin Gurney
发明人： Camellia Adams , Austin Gurney
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2866 , C07K16/40 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/74 , C07K2317/75 , C07K2317/92
摘要： Various forms of c-mpl agonist antibodies are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.
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公开(公告)号：US20060198843A1
公开(公告)日：2006-09-07
申请号：US11429043
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395 , A61K31/7072 , A61K31/337 , A61K31/282 , A61K33/24
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and chemotherapeutic agents.
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公开(公告)号：US20060073143A1
公开(公告)日：2006-04-06
申请号：US11222587
申请日：2005-09-09
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and anti-hormonal compounds, such as anti-estrogens.
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公开(公告)号：US20060034842A1
公开(公告)日：2006-02-16
申请号：US11223361
申请日：2005-09-09
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating ErbB-expressing cancer with anti-ErbB2 antibody combinations.
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6.发明申请公开(公告)号：US20060193854A1
公开(公告)日：2006-08-31
申请号：US11429361
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395 , A61K31/525 , A61K31/7072 , A61K31/282 , A61K31/337 , A61K33/24
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
摘要翻译： 本申请描述了人源化抗ErbB2抗体和用抗ErbB2抗体如人源化抗ErbB2抗体治疗癌症的方法。
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公开(公告)号：US20060115484A1
公开(公告)日：2006-06-01
申请号：US11297319
申请日：2005-12-09
申请人： Camellia Adams , Avi Ashkenazi , Anan Chuntharapai , Kyung Kim
发明人： Camellia Adams , Avi Ashkenazi , Anan Chuntharapai , Kyung Kim
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N9/64 , C07K16/40
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
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公开(公告)号：US20060073570A1
公开(公告)日：2006-04-06
申请号：US11297327
申请日：2005-12-09
申请人： Camellia Adams , Avi Ashkenazi , Anan Chuntharapai , Kyung Kim
发明人： Camellia Adams , Avi Ashkenazi , Anan Chuntharapai , Kyung Kim
IPC分类号： C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
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公开(公告)号：US20070031414A1
公开(公告)日：2007-02-08
申请号：US11546133
申请日：2006-10-10
申请人： Camellia Adams
发明人： Camellia Adams
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/24
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/565
摘要： The invention concerns anti-DR5 antibodies with improved properties, compositions comprising such antibodies, methods and means for making such antibodies, and their therapeutic use, in particular in the treatment of cancer.
摘要翻译： 本发明涉及具有改进性质的抗DR5抗体，包含此类抗体的组合物，用于制备此类抗体的方法和手段及其治疗用途，特别是治疗癌症。
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公开(公告)号：US20060216285A1
公开(公告)日：2006-09-28
申请号：US11429363
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
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