公开(公告)号：US08128872B2

公开(公告)日：2012-03-06

申请号：US12511025

申请日：2009-07-28

申请人： Carl Lentz ,  Dawn E. Smith ,  Dene H. Taylor

发明人： Carl Lentz ,  Dawn E. Smith ,  Dene H. Taylor

IPC分类号： G01N25/20 ,  G01K11/12

CPC分类号： G01K11/06 ,  G01K3/04 ,  Y10S252/962

摘要： Freeze indicators can include an indicator dispersion, a liquid medium, indicator particles dispersed in the liquid medium and a particulate inorganic nucleating agent to inhibit supercooling of the liquid medium. The inorganic nucleating agent can have an ionic surface coating which can help provide a sharp end point. Optionally, freeze indicators can include indicator particles comprising an organic material and a softener to soften the indicator particles and provide the freeze indication with an enhanced visual appearance. Another option is to provide a temperature-sensitive stabilizer to inhibit coagulation of the indicator dispersion at temperatures above the liquid medium frozen state melting point while permitting coagulation of the indicator dispersion at the liquid medium frozen state melting point.

摘要翻译： 冷冻指示剂可以包括指示剂分散体，液体介质，分散在液体介质中的指示剂颗粒和颗粒状无机成核剂以抑制液体介质的过冷。 无机成核剂可以具有可以帮助提供尖锐终点的​​离子表面涂层。 任选地，冷冻指示器可以包括包含有机材料和柔软剂的指示剂颗粒，以软化指示剂颗粒并提供具有增强的视觉外观的冷冻指示。 另一个选择是提供温度敏感的稳定剂，以在高于液体介质冷冻状态熔点的温度下抑制指示剂分散体的凝结，同时允许指示剂分散体在液体介质冷冻状态熔点下凝结。

公开(公告)号：US20100162941A1

公开(公告)日：2010-07-01

申请号：US12511025

申请日：2009-07-28

申请人： Carl Lentz ,  Dawn E. Smith ,  Dene H. Taylor

发明人： Carl Lentz ,  Dawn E. Smith ,  Dene H. Taylor

IPC分类号： G01K1/02 ,  B05D7/00

CPC分类号： G01K11/06 ,  G01K3/04 ,  Y10S252/962

摘要： Freeze indicators can include an indicator dispersion, a liquid medium, indicator particles dispersed in the liquid medium and a particulate inorganic nucleating agent to inhibit supercooling of the liquid medium. The inorganic nucleating agent can have an ionic surface coating which can help provide a sharp end point. Optionally, freeze indicators can include indicator particles comprising an organic material and a softener to soften the indicator particles and provide the freeze indication with an enhanced visual appearance. Another option is to provide a temperature-sensitive stabilizer to inhibit coagulation of the indicator dispersion at temperatures above the liquid medium frozen state melting point while permitting coagulation of the indicator dispersion at the liquid medium frozen state melting point.

摘要翻译： 冷冻指示剂可以包括指示剂分散体，液体介质，分散在液体介质中的指示剂颗粒和颗粒状无机成核剂以抑制液体介质的过冷。 无机成核剂可以具有可以帮助提供尖锐终点的​​离子表面涂层。 任选地，冷冻指示器可以包括包含有机材料和柔软剂的指示剂颗粒，以软化指示剂颗粒并提供具有增强的视觉外观的冷冻指示。 另一个选择是提供温度敏感的稳定剂，以在高于液体介质冷冻状态熔点的温度下抑制指示剂分散体的凝结，同时允许指示剂分散体在液体介质冷冻状态熔点下凝结。

公开(公告)号：US08122844B2

公开(公告)日：2012-02-28

申请号：US12871034

申请日：2010-08-30

申请人： Dawn E. Smith ,  Carl M. Lentz ,  Dene H. Taylor ,  Yvonne Osunga ,  Brian Huffman

发明人： Dawn E. Smith ,  Carl M. Lentz ,  Dene H. Taylor ,  Yvonne Osunga ,  Brian Huffman

IPC分类号： G01K11/12 ,  G01K11/16 ,  G01K11/18

CPC分类号： G01K11/12 ,  G01K11/08 ,  G01K11/16 ,  G01K11/18

摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about −1.9° C. or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.

摘要翻译： 冷冻指示剂可以包括具有水性液体介质的指示剂分散体和分散在水性液体介质中的有机材料指示剂颗粒。 指示剂分散体在冷冻之前可以具有初始外观，并且在冷冻后具有不可逆的外观，并且可以表现出约-1.9℃或更高的冷冻起始温度。 有助于提供相对高的冷冻起始温度的一些因素是使用蛋白质冰成核剂，控制pH，使用蛋白质稳定剂和控制蛋白质稳定剂与冰 - 成核剂的比例。

公开(公告)号：US07624698B2

公开(公告)日：2009-12-01

申请号：US12069025

申请日：2008-02-06

申请人： Dene H. Taylor ,  Thaddeus Prusik ,  Dawn E. Smith

发明人： Dene H. Taylor ,  Thaddeus Prusik ,  Dawn E. Smith

IPC分类号： G01K11/12 ,  G01K11/14

CPC分类号： G01K1/02 ,  G01K3/005 ,  G01K11/06 ,  G01K11/12 ,  G01K2207/04 ,  Y10S252/962

摘要： A freeze indicator employs, as active indicator element, dispersion of solid particles in a liquid medium which can be water or aqueous and which coagulates to provide an irreversible appearance change when subject to freezing. The liquid dispersion can be contained in an indicator volume around which extends a vapor block layer. The vapor block layer can prevent loss of liquid vapor from the dispersion and consequent drying out and dysfunctionality of the freeze indicator. For containing an aqueous medium, bilayer and trilayer laminate materials can be used which have a low water vapor transmission rate. The active indicator element can be a dilute colloidal dispersion of a metal such as gold or silver or other inorganic pigment material in water or an aqueous medium. Some embodiments avoid use of dispersants and the like and employ an active indicator element consisting of inorganic pigment particles, water and optionally an ice nucleating agent. Heavy water, or deuterated water can be components of the water, if desired.

摘要翻译： 冷冻指示器使用固体颗粒在液体介质中的分散体作为活性指示剂元素，液体介质可以是水或水，并在凝固时提供不可逆的外观变化。 液体分散体可以包含在延伸蒸气阻挡层的指示体积中。 蒸气阻挡层可以防止液体蒸气从分散体中的损失，从而导致冷冻指示器的干燥和功能失调。 为了含有水性介质，可以使用具有低水蒸气透过率的双层和三层层压材料。 活性指示剂元素可以是诸如金或银之类的金属或其它无机颜料材料在水或水介质中的稀释胶体分散体。 一些实施方案避免使用分散剂等并且使用由无机颜料颗粒，水和任选的冰核成核剂组成的活性指示剂元件。 如果需要，重水或氘代水可以是水的组分。

公开(公告)号：US20120079980A1

公开(公告)日：2012-04-05

申请号：US13246392

申请日：2011-09-27

申请人： Dene H. TAYLOR ,  Carl M. Lentz ,  Dawn E. Smith

发明人： Dene H. TAYLOR ,  Carl M. Lentz ,  Dawn E. Smith

IPC分类号： G01D21/00 ,  G01N21/75

CPC分类号： G01K11/12 ,  G01K3/04 ,  G01K11/06

摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.

摘要翻译： 用于冷冻指示剂的变色乳液可以使用分散介质，例如水性液体，第一反应物相和第二反应物相，其中两个反应物相都可以分散在分散介质中。 第一反应物相包括疏水性液体和第一反应物，例如着色前体如无色染料。 第二反应物相可以包括疏水性液体，并且包括或可以是第二反应物，例如彩色显影剂，例如无色染料显影剂。 第一和第二反应物相可以基本上不混合，并且可以共同反应以提供颜色变化。 响应于冷冻温度，变色乳液可以不可逆地凝结和变色。 通过使用例如合适的无色染料前体和显影剂可以获得强烈的颜色变化。

公开(公告)号：US08430053B2

公开(公告)日：2013-04-30

申请号：US13246392

申请日：2011-09-27

申请人： Dene H. Taylor ,  Carl M. Lentz ,  Dawn E. Smith

发明人： Dene H. Taylor ,  Carl M. Lentz ,  Dawn E. Smith

IPC分类号： G01D21/00

CPC分类号： G01K11/12 ,  G01K3/04 ,  G01K11/06

摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.

摘要翻译： 用于冷冻指示剂的变色乳液可以使用分散介质，例如水性液体，第一反应物相和第二反应物相，其中两个反应物相都可以分散在分散介质中。 第一反应物相包括疏水性液体和第一反应物，例如着色前体如无色染料。 第二反应物相可以包括疏水性液体，并且包括或可以是第二反应物，例如彩色显影剂，例如无色染料显影剂。 第一和第二反应物相可以基本上不混合，并且可以共同反应以提供颜色变化。 响应于冷冻温度，变色乳液可以不可逆地凝结和变色。 通过使用例如合适的无色染料前体和显影剂可以获得强烈的颜色变化。

公开(公告)号：US20100024714A1

公开(公告)日：2010-02-04

申请号：US12500799

申请日：2009-07-10

申请人： Dene H. TAYLOR ,  Thaddeus Prusik ,  Dawn E. Smith ,  Ray H. Baughman

发明人： Dene H. TAYLOR ,  Thaddeus Prusik ,  Dawn E. Smith ,  Ray H. Baughman

IPC分类号： G01K1/02 ,  G01D21/00

CPC分类号： G01K3/005 ,  G01K3/04 ,  G01K11/06 ,  Y10S252/962

摘要： Freeze indicators providing a visual indication of exposure of the freeze indicator to a freezing or near-freezing temperature and their manufacture are disclosed. The freeze indicators employ colloidal dispersions as active elements and include flexible freeze indicators, freeze indicators protected against drying out and freeze indicators employing core shell composites, for example gold coated pigments as active indicator elements. Also disclosed are: a combination freeze indicator and threshold temperature indicator; a combination threshold indicator and cumulative temperature indicator; and three-way combination indicators that can provide indications of cumulative past temperature exposure, exposure to freezing temperatures and exposure to a temperature above a threshold.

摘要翻译： 公开了冻结指示器，其提供了将冷冻指示剂暴露于冷冻或接近冻结温度的视觉指示及其制造。 冻结指示剂使用胶体分散体作为活性元素，并且包括灵活的冷冻指示剂，防止干燥的冷冻指示剂和使用核心壳复合材料的冷冻指示剂，例如镀金颜料作为活性指示剂元素。 还公开了：组合冻结指示器和阈值温度指示器; 组合阈值指标和累积温度指标; 和三路组合指示器，可以提供累积过去的温度暴露，暴露于冷冻温度和暴露于高于阈值的温度的指示。

公开(公告)号：US07891310B2

公开(公告)日：2011-02-22

申请号：US12500799

申请日：2009-07-10

申请人： Dene H. Taylor ,  Thaddeus Prusik ,  Dawn E. Smith ,  Ray H. Baughman

发明人： Dene H. Taylor ,  Thaddeus Prusik ,  Dawn E. Smith ,  Ray H. Baughman

IPC分类号： G01K11/12 ,  G01K3/00

CPC分类号： G01K3/005 ,  G01K3/04 ,  G01K11/06 ,  Y10S252/962

摘要： Freeze indicators providing a visual indication of exposure of the freeze indicator to a freezing or near-freezing temperature and their manufacture are disclosed. The freeze indicators employ colloidal dispersions as active elements and include flexible freeze indicators, freeze indicators protected against drying out and freeze indicators employing core shell composites, for example gold coated pigments as active indicator elements. Also disclosed are: a combination freeze indicator and threshold temperature indicator; a combination threshold indicator and cumulative temperature indicator; and three-way combination indicators that can provide indications of cumulative past temperature exposure, exposure to freezing temperatures and exposure to a temperature above a threshold.

摘要翻译： 公开了冻结指示器，其提供了将冷冻指示剂暴露于冷冻或接近冻结温度的视觉指示及其制造。 冻结指示剂使用胶体分散体作为活性元素，并且包括灵活的冷冻指示剂，防止干燥的冷冻指示剂和使用核心壳复合材料的冷冻指示剂，例如镀金颜料作为活性指示剂元素。 还公开了：组合冻结指示器和阈值温度指示器; 组合阈值指标和累积温度指标; 和三路组合指示器，可以提供累积过去的温度暴露，暴露于冷冻温度和暴露于高于阈值的温度的指示。

公开(公告)号：US07571695B2

公开(公告)日：2009-08-11

申请号：US11750054

申请日：2007-05-17

申请人： Dene H. Taylor ,  Thaddeus Prusik ,  Dawn E. Smith ,  Ray H. Baughman

发明人： Dene H. Taylor ,  Thaddeus Prusik ,  Dawn E. Smith ,  Ray H. Baughman

IPC分类号： G01K11/12

CPC分类号： G01K3/005 ,  G01K3/04 ,  G01K11/06 ,  Y10S252/962

摘要： Freeze indicators providing a visual indication of exposure of the freeze indicator to a freezing or near-freezing temperature and their manufacture are disclosed. The freeze indicators employ colloidal dispersions as active elements and include flexible freeze indicators, freeze indicators protected against drying out and freeze indicators employing core shell composites, for example gold coated pigments as active indicator elements. Also disclosed are: a combination freeze indicator and threshold temperature indicator; a combination threshold indicator and cumulative temperature indicator; and three-way combination indicators that can provide indications of cumulative past temperature exposure, exposure to freezing temperatures and exposure to a temperature above a threshold.

摘要翻译： 公开了冻结指示器，其提供了将冷冻指示剂暴露于冷冻或接近冻结温度的视觉指示及其制造。 冻结指示剂使用胶体分散体作为活性元素，并且包括灵活的冷冻指示剂，防止干燥的冷冻指示剂和使用核心壳复合材料的冷冻指示剂，例如镀金颜料作为活性指示剂元素。 还公开了：组合冻结指示器和阈值温度指示器; 组合阈值指标和累积温度指标; 和三路组合指示器，可以提供累积过去的温度暴露，暴露于冷冻温度和暴露于高于阈值的温度的指示。

公开(公告)号：US08269042B2

公开(公告)日：2012-09-18

申请号：US12261887

申请日：2008-10-30

申请人： Ray H. Baughman ,  Lee J. Hall ,  Mikhail Kozlov ,  Dawn E. Smith ,  Thaddeus Prusik

发明人： Ray H. Baughman ,  Lee J. Hall ,  Mikhail Kozlov ,  Dawn E. Smith ,  Thaddeus Prusik

IPC分类号： C07C275/04

CPC分类号： G01K11/12 ,  C07C273/02 ,  C07C275/20 ,  C09B69/10 ,  G01K3/04 ,  G01N21/78 ,  G01N31/22 ,  G01N31/229

摘要： Crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic compounds and mixtures crystallized from diacetylenic solutions; methods of preparing and identifying solvent systems for dissolving diacetylenic compounds; diacetylenic solutions; methods of recrystallizing diacetylenic compounds; crystals of 2,4-hexadiyn-1,6-bis(alkylurea) compounds; and ambient condition indicators and time-temperature condition indicators comprising crystallized diacetylenic compounds.

摘要翻译： 具有某些晶体学特性的结晶二炔化合物; 二乙炔化合物和从二乙炔溶液中结晶的混合物; 制备和鉴定溶解二乙炔化合物的溶剂体系的方法; 二乙酰溶液; 二乙炔化合物重结晶方法; 2,4-己二炔-1,6-双（烷基脲）化合物的晶体; 环境条件指标和包含结晶二乙炔化合物的时间 - 温度条件指标。