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1.发明授权Mycobacterium membrane protease as a target for inhibitors of intrabacterial pH homeostasis 有权分枝杆菌膜蛋白酶作为细菌内pH稳态抑制剂的靶标公开(公告)号：US08951992B2
公开(公告)日：2015-02-10
申请号：US13000788
申请日：2009-07-20
申请人： Carl Nathan , Sabine Ehrt , Omar Vandal , Crystal Darby
发明人： Carl Nathan , Sabine Ehrt , Omar Vandal , Crystal Darby
IPC分类号： A61K31/365 , A61K31/351 , A61K31/381 , A01N25/06 , A01N43/08 , A01N43/16 , C12N9/88 , C12N1/36 , C12N9/99 , C12Q1/18 , G01N33/84
摘要： The present invention is directed to methods and compounds for inhibiting bacterial growth and treating a bacterial infection in a subject. These methods involve providing an inhibitor of intrabacterial pH homeostasis, including inhibitors of the Mycobacterium tuberculosis Rv3671c gene encoded membrane protease. Methods for identifying novel compounds that disrupt intrabacterial pH homeostasis and their use for inhibiting bacterial growth and treating a bacterial infection in a subject are also disclosed.
摘要翻译： 本发明涉及用于抑制细菌生长和治疗受试者细菌感染的方法和化合物。 这些方法包括提供细菌内pH稳态抑制剂，包括结核分枝杆菌Rv3671c基因编码膜蛋白酶的抑制剂。 还公开了鉴定破坏细菌内pH稳定的新化合物及其用于抑制细菌生长和治疗受试者的细菌感染的方法。
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2.发明申请MYCOBACTERIUM MEMBRANE PROTEASE AS A TARGET FOR INHIBITORS OF INTRABACTERIAL pH HOMEOSTASIS 有权MYCOBACTERIUM膜蛋白作为靶向抑制剂的目标公开(公告)号：US20110190234A1
公开(公告)日：2011-08-04
申请号：US13000788
申请日：2009-07-20
申请人： Carl Nathan , Sabine Ehrt , Omar Vandal , Crystal Darby
发明人： Carl Nathan , Sabine Ehrt , Omar Vandal , Crystal Darby
IPC分类号： A01N43/16 , A61K31/37 , A61P31/06 , A61P31/04 , A61P31/08 , C12Q1/02 , A01P15/00 , A01N35/06 , A61K31/122 , A01N43/24 , A61K31/365 , A01N43/12 , A01N43/08 , A61K31/351 , A01N37/02 , A61K31/20 , A61K31/702 , A01N43/10 , A61K31/381
摘要： The present invention is directed to methods and compounds for inhibiting bacterial growth and treating a bacterial infection in a subject. These methods involve providing an inhibitor of intrabacterial pH homeostasis, including inhibitors of the Mycobacterium tuberculosis Rv3671c gene encoded membrane protease. Methods for identifying novel compounds that disrupt intrabacterial pH homeostasis and their use for inhibiting bacterial growth and treating a bacterial infection in a subject are also disclosed.
摘要翻译： 本发明涉及用于抑制细菌生长和治疗受试者细菌感染的方法和化合物。 这些方法包括提供细菌内pH稳态抑制剂，包括结核分枝杆菌Rv3671c基因编码膜蛋白酶的抑制剂。 还公开了鉴定破坏细菌内pH稳定的新化合物及其用于抑制细菌生长和治疗受试者的细菌感染的方法。
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3.发明授权Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation 失效用嗜中性粒细胞活化化学抑制剂治疗粘连嗜中性粒细胞炎症性疾病或抑制呼吸爆发公开(公告)号：US07977366B2
公开(公告)日：2011-07-12
申请号：US10575683
申请日：2004-10-14
申请人： Hyunsil Han , Gang Lin , Carl Nathan
发明人： Hyunsil Han , Gang Lin , Carl Nathan
IPC分类号： A61K31/4709 , A61K31/41 , A61P37/00
CPC分类号： A61K31/425 , A61K31/415 , C07D231/22 , C07D277/74 , C07D495/04 , Y02A50/414 , Y02A50/423 , Y02A50/475
摘要： The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.
摘要翻译： 本发明涉及在有效治疗炎症性疾病的条件下，用有效量的本申请所述通式（I）的化合物治疗受试者的炎症性疾病的方法。 本发明还涉及一种抑制嗜中性粒细胞呼吸爆发的方法，而不会通过将嗜中性粒细胞与上述化合物接触而抑制嗜中性粒细胞的脱粒或细菌杀伤。
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公开(公告)号：US07427595B1
公开(公告)日：2008-09-23
申请号：US10735289
申请日：2003-12-12
申请人： Jing Zhu , Aihao Ding , Carl Nathan
发明人： Jing Zhu , Aihao Ding , Carl Nathan
CPC分类号： A61K38/1709 , C07K14/47
摘要： The invention is directed to compositions and methods for wound healing and controlling inflammation that involve proepithelin, with or without secretory leukocyte protease inhibitor (SLPI).
摘要翻译： 本发明涉及用于伤口愈合和控制涉及含有或不伴有分泌白细胞蛋白酶抑制剂（SLPI）的前列腺素的炎症的组合物和方法。
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5.发明申请PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER 审中-公开缓释抑制剂及其在治疗病原体感染和癌症中的应用公开(公告)号：US20110118274A1
公开(公告)日：2011-05-19
申请号：US12674820
申请日：2008-08-25
申请人： Carl Nathan , Gang Lin
发明人： Carl Nathan , Gang Lin
IPC分类号： A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/497 , C07D419/04 , A61P35/00 , A61P31/06 , A61P31/00 , A61P31/04 , A61P31/08
CPC分类号： C07D419/04 , A61K31/42 , A61K31/425
摘要： The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
摘要翻译： 本发明涉及蛋白酶体抑制剂及其在治疗受试者病原体感染或癌症的方法中的用途。 所述方法涉及向受试者施用式（I）的化合物。 （I）其中：Q是式或式，其中交叉虚线示出了形成连接Q与式（I）化合物的其余部分的键。 式（I）化合物的其余取代基在本申请中定义。
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6.发明申请Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation 失效用嗜中性粒细胞活化化学抑制剂治疗粘连嗜中性粒细胞炎症性疾病或抑制呼吸爆发公开(公告)号：US20070021448A1
公开(公告)日：2007-01-25
申请号：US10575683
申请日：2004-10-14
申请人： Hyunsil Han , Gang Lin , Carl Nathan
发明人： Hyunsil Han , Gang Lin , Carl Nathan
IPC分类号： A61K31/519 , A61K31/4709 , A61K31/428 , A61K31/4152
CPC分类号： A61K31/425 , A61K31/415 , C07D231/22 , C07D277/74 , C07D495/04 , Y02A50/414 , Y02A50/423 , Y02A50/475
摘要： The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without or inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.
摘要翻译： 本发明涉及在有效治疗炎症性疾病的条件下，用有效量的本申请所述通式（I）的化合物治疗受试者的炎症性疾病的方法。 本发明还涉及一种通过使嗜中性粒细胞与上述化合物接触而抑制嗜中性粒细胞呼吸爆发而不抑制或抑制嗜中性粒细胞脱颗粒或细菌性杀伤的方法。
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公开(公告)号：US5850004A
公开(公告)日：1998-12-15
申请号：US808191
申请日：1997-02-28
申请人： John MacMicking , Carl Nathan , John S. Mudgett
发明人： John MacMicking , Carl Nathan , John S. Mudgett
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03
摘要： The present invention provides an inducible nitric oxide synthase ("iNOS")-deficient transgenic mouse, novel replacement vectors designed for the disruption of the iNOS gene, embryonic stem (ES) cells which are singly allelic relative to the deficient iNOS locus, a host cell line or cell clone carrying a congenitally altered iNOS gene, and a method of producing such a transgenic mouse. The iNOS-deficient transgenic mice can be used to evaluate and/or test their susceptibility to infectious or tumorigenic challenge, autoimmunity, septic shock and inflammatory and allergic diseases.
摘要翻译： 本发明提供了诱导型一氧化氮合酶（“iNOS”）缺陷转基因小鼠，设计用于iNOS基因破坏的新型替代载体，相对于缺陷型iNOS基因座单等位基因的胚胎干（ES）细胞，宿主 携带先天改变的iNOS基因的细胞系或细胞克隆，以及生产这种转基因小鼠的方法。 iNOS缺陷转基因小鼠可用于评估和/或测试其对感染性或致瘤性攻击，自身免疫，败血性休克和炎性和过敏性疾病的易感性。
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