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1.发明申请公开(公告)号：US20220075169A1
公开(公告)日：2022-03-10
申请号：US17463653
申请日：2021-09-01
摘要： An arrangement for light sheet microscopy contains an illumination objective for illuminating a sample located on a slide in a medium with a light sheet, a detection objective, a separation layer system, a first adaptive optical detection correction element, and a further adaptive optical detection correction element and/or a first adaptive optical illumination correction element, and optionally, a further adaptive optical illumination correction element. The arrangement contains an adjustment device for the controlled movement of the first detection correction element and of the further detection correction element and/or of the first illumination correction element and of the further illumination correction element; and a control unit, to generate control commands and to actuate the adjustment devices by means of the control commands such that aberrations are reduced. Corresponding objectives and a corresponding method for reducing aberrations can be used.
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2.发明授权公开(公告)号：US11841490B2
公开(公告)日：2023-12-12
申请号：US17463653
申请日：2021-09-01
CPC分类号： G02B21/0032 , G02B21/367 , G06T2207/10056
摘要： An arrangement for light sheet microscopy contains an illumination objective for illuminating a sample located on a slide in a medium with a light sheet, a detection objective, a separation layer system, a first adaptive optical detection correction element, and a further adaptive optical detection correction element and/or a first adaptive optical illumination correction element, and optionally, a further adaptive optical illumination correction element. The arrangement contains an adjustment device for the controlled movement of the first detection correction element and of the further detection correction element and/or of the first illumination correction element and of the further illumination correction element; and a control unit, to generate control commands and to actuate the adjustment devices by means of the control commands such that aberrations are reduced. Corresponding objectives and a corresponding method for reducing aberrations can be used.
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公开(公告)号：US11163147B2
公开(公告)日：2021-11-02
申请号：US16313645
申请日：2017-06-29
发明人： Jörg Siebenmorgen , Helmut Lippert , Thomas Kalkbrenner , Ingo Kleppe , Ralf Wolleschensky , Artur Degen , Matthias Wald , Lars-Christian Wittig , Michael Gölles , Wolfgang Singer
摘要： An arrangement for microscopy, having an illumination optical unit with an illumination objective for illuminating a specimen on a specimen carrier. An optical axis of the illumination objective lies in a plane which includes an illumination angle that differs from zero with the normal of a specimen plane and the illumination is implemented in the plane. A detection optical unit with a detection objective is located in a detection beam path. The optical axis of the detection objective includes a detection angle that differs from zero with the normal of the specimen plane. The illumination objective and/or the detection objective has an illumination correction element. A meniscus lens is located between the specimen carrier and the illumination and detection objectives being arranged both in the illumination beam path and in the detection beam path.
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4.发明申请公开(公告)号：US20160291303A1
公开(公告)日：2016-10-06
申请号：US15036582
申请日：2014-11-13
发明人： Artur DEGEN , Michael Gölles , Jörg SIEBENMORGEN , Helmut Lippert , Thomas Kalkbrenner , Ingo Kleppe , Matthias Wald , Lars-Christian Wittig , Wolfgang SINGER , Ralf WOLLESCHENSKY
CPC分类号： G02B21/0032 , G02B3/04 , G02B21/0052 , G02B21/0076 , G02B21/02 , G02B21/248 , G02B21/33 , G02B21/34 , G02B21/367 , G02B27/0025
摘要： An optical transmission system configured to image a selected region of a sample arranged in a first medium in an object plane on or in a sample carrier, which includes plane-parallel plate, from the object plane into an intermediate image plane in a second medium. The plane-parallel plate is located between the optical transmission system and the sample during the imaging. The object plane and the intermediate image plane form an angle between 0° and 90° with an optical axis of the transmission system. The optical transmission system is positioned relative to region of the sample such that the sample is located within the focal length of the lens of the optical transmission system closest to the sample. The intermediate image plane and the object plane are located on the same side of the optical transmission system, and the intermediate image is a virtual image.
摘要翻译： 一种光传输系统，被配置为将布置在包括平面平行板的样品载体上的或其中的物体平面中的第一介质中的样品的选定区域成像到第二介质中的中间图像平面。 平面平行板在成像期间位于光传输系统和样品之间。 物平面和中间像平面与传输系统的光轴形成0°和90°之间的角度。 光传输系统相对于样品的区域定位，使得样品位于最接近样品的光传输系统的透镜的焦距内。 中间图像平面和物平面位于光传输系统的同一侧，中间图像是虚像。
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公开(公告)号：US20150145981A1
公开(公告)日：2015-05-28
申请号：US14383628
申请日：2013-02-28
CPC分类号： G02B26/02 , G01N21/6458 , G02B21/0032 , G02B21/0064 , G02B21/0076 , G02B21/008 , G02B2207/113 , H04N5/23296
摘要： A light scanning microscope with an illumination module switchable between an illumination with m number of spots and an illumination with n number of spots, a deflecting unit which moves the m or n spots in a predetermined sample region, and a detector module for confocal and spectrally resolved detection of the sample radiation. The detector module has a confocal diaphragm unit, a splitting unit which is arranged downstream of the confocal diaphragm unit, a detector, and an imaging unit which images the partial beams on the detector in a spatially separated manner. The confocal diaphragm unit is switchable between a confocal diaphragm with exactly m apertures for m-spot illumination and a confocal diaphragm with n apertures for n-spot illumination. The splitting unit has a first beam path for m-spot illumination and a second beam path for n-spot illumination. The splitting unit is switchable between the two beam paths.
摘要翻译： 一种光扫描显微镜，其具有可在具有m个点的照明和具有n个点的照明之间切换的照明模块，用于移动预定样本区域中的m个或n个点的偏转单元和用于共焦和光谱的检测器模块 分辨检测样品辐射。 检测器模块具有共聚焦膜单元，分配单元，其布置在共聚焦膜单元的下游，检测器和成像单元，其以空间分离的方式对检测器上的部分光束进行成像。 共聚焦膜单元可在具有精确m个孔径的m光点照射的共聚焦膜和具有n个用于n光点照明的孔的共聚焦膜之间切换。 分割单元具有用于m点照明的第一光束路径和用于n光点照明的第二光束路径。 分离单元可在两个光束路径之间切换。
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公开(公告)号：US10048478B2
公开(公告)日：2018-08-14
申请号：US15036582
申请日：2014-11-13
发明人： Artur Degen , Michael Gölles , Jörg Siebenmorgen , Helmut Lippert , Thomas Kalkbrenner , Ingo Kleppe , Matthias Wald , Lars-Christian Wittig , Wolfgang Singer , Ralf Wolleschensky
IPC分类号： G02B21/06 , G02B21/00 , G02B27/00 , G02B21/02 , G02B21/36 , G02B3/04 , G02B21/24 , G02B21/33 , G02B21/34
摘要： An optical transmission system configured to image a selected region of a sample arranged in a first medium in an object plane on or in a sample carrier, which includes plane-parallel plate, from the object plane into an intermediate image plane in a second medium. The plane-parallel plate is located between the optical transmission system and the sample during the imaging. The object plane and the intermediate image plane form an angle between 0° and 90° with an optical axis of the transmission system. The optical transmission system is positioned relative to region of the sample such that the sample is located within the focal length of the lens of the optical transmission system closest to the sample. The intermediate image plane and the object plane are located on the same side of the optical transmission system, and the intermediate image is a virtual image.
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公开(公告)号：US09989754B2
公开(公告)日：2018-06-05
申请号：US14383628
申请日：2013-02-28
CPC分类号： G02B26/02 , G01N21/6458 , G02B21/0032 , G02B21/0064 , G02B21/0076 , G02B21/008 , G02B2207/113 , H04N5/23296
摘要： A light scanning microscope with an illumination module switchable between an illumination with m number of spots and an illumination with n number of spots, a deflecting unit which moves the m or n spots in a predetermined sample region, and a detector module for confocal and spectrally resolved detection of the sample radiation. The detector module has a confocal diaphragm unit, a splitting unit which is arranged downstream of the confocal diaphragm unit, a detector, and an imaging unit which images the partial beams on the detector in a spatially separated manner. The confocal diaphragm unit is switchable between a confocal diaphragm with exactly m apertures for m-spot illumination and a confocal diaphragm with n apertures for n-spot illumination. The splitting unit has a first beam path for m-spot illumination and a second beam path for n-spot illumination. The splitting unit is switchable between the two beam paths.
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