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    Hydroxylamine derivatives
    1.
    发明申请
    Hydroxylamine derivatives 有权
    羟胺衍生物

    公开(公告)号：US20070049643A1

    公开(公告)日：2007-03-01

    申请号：US10582141

    申请日：2004-12-10

    申请人： Carla Caccia ,  Laura Girola ,  Petra Kaltofen ,  Daniele Losi ,  Patricia Salvati ,  Enrico Selva ,  Florian Thaler

    发明人： Carla Caccia ,  Laura Girola ,  Petra Kaltofen ,  Daniele Losi ,  Patricia Salvati ,  Enrico Selva ,  Florian Thaler

    IPC分类号： A61K31/13

    CPC分类号： C07C239/20 ,  A61K31/13 ,  C07C239/12 ,  C07C2602/10

    摘要： This invention is related to hydroxylamino derivatives of the general formula (I) wherein n is 0, 1 or 2; R1 and R2, independently of each other, are H, OH or OCH3; R3 is H or CH3; R4 is H, C1-C3 straight or branched alkyl or, together with R3, forms a five to seven-membered carbocyclic ring; and R5 and R6, independently of each other, are H or C1-C5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing said compounds and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及通式（I）的羟基氨基衍生物，其中n为0,1或2; R 1和R 2彼此独立地是H，OH或OCH 3; R 3是H或CH 3 N; R 4是H，C 1 -C 3直链或支链烷基，或与R 3'一起形成 五至七元碳环; 和R 5和R 6彼此独立地是H或C 1 -C 5直链或 支链烷基及其药学上可接受的盐或前药，用于制备可用于预防，治疗和诊断与蛋白质错折叠和/或解聚相关的CNS退行性疾病的药物。 本发明还涉及式（I）中包括的新化合物，涉及制备所述化合物的方法和含有它们的药物组合物。

    HYDROXYLAMINE DERIVATIVES
    2.
    发明申请
    HYDROXYLAMINE DERIVATIVES 审中-公开
    羟基胺衍生物

    公开(公告)号：US20100197799A1

    公开(公告)日：2010-08-05

    申请号：US12760007

    申请日：2010-04-14

    申请人： Carla CACCIA ,  Laura Girola ,  Petra Karin Kaltofen ,  Daniele Losi ,  Patricia Salvati ,  Enrico Selva ,  Florian Thaler

    发明人： Carla CACCIA ,  Laura Girola ,  Petra Karin Kaltofen ,  Daniele Losi ,  Patricia Salvati ,  Enrico Selva ,  Florian Thaler

    IPC分类号： A61K31/13 ,  C07C239/20 ,  A61P25/16 ,  A61P25/28

    CPC分类号： C07C239/20 ,  A61K31/13 ,  C07C239/12 ,  C07C2602/10

    摘要： This invention is related to hydroxylamino derivatives of the following general formula (I) wherein n is 0, 1 or 2; R1 and R2, independently of each other, are H, OH or OCH3; R3 is H or CH3; R4 is H, C1-C3 straight or branched alkyl or, together with R3, forms a five to seven-membered carbocyclic ring; and R5 and R6, independently of each other, are H or C1-C5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing the compounds and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及以下通式（I）的羟基氨基衍生物，其中n为0,1或2; R 1和R 2彼此独立地是H，OH或OCH 3; R3是H或CH3; R4是H，C1-C3直链或支链烷基，或与R3一起形成五至七元碳环; 和R5和R6彼此独立地是H或C 1 -C 5直链或支链烷基及其药学上可接受的盐或前药，用于制备用于预防，治疗和诊断与蛋白质错折叠相关的CNS退行性病症的药物 和/或散乱。 本发明还涉及式（I）中包括的新化合物，涉及制备该化合物的方法和含有该化合物的药物组合物。

    Hydroxylamine derivatives
    3.
    发明授权
    Hydroxylamine derivatives 有权
    羟胺衍生物

    公开(公告)号：US07763751B2

    公开(公告)日：2010-07-27

    申请号：US10582141

    申请日：2004-12-10

    申请人： Carla Caccia ,  Laura Girola ,  Petra Karin Kaltofen ,  Daniele Losi ,  Patricia Salvati ,  Enrico Selva ,  Florian Thaler

    发明人： Carla Caccia ,  Laura Girola ,  Petra Karin Kaltofen ,  Daniele Losi ,  Patricia Salvati ,  Enrico Selva ,  Florian Thaler

    IPC分类号： C07C239/00 ,  A61K31/13

    CPC分类号： C07C239/20 ,  A61K31/13 ,  C07C239/12 ,  C07C2602/10

    摘要： This invention is related to hydroxylamino derivatives of the general formula (I) wherein n is 0, 1 or 2; R1 and R2, independently of each other, are H, OH or OCH3; R3 is H or CH3; R4 is H, C1-C3 straight or branched alkyl or, together with R3, forms a five to seven-membered carbocyclic ring; and R5 and R6, independently of each other, are H or C1-C5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing said compounds and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及通式（I）的羟基氨基衍生物，其中n为0,1或2; R 1和R 2彼此独立地是H，OH或OCH 3; R3是H或CH3; R4是H，C1-C3直链或支链烷基，或与R3一起形成五至七元碳环; 和R5和R6彼此独立地是H或C 1 -C 5直链或支链烷基及其药学上可接受的盐或前药，用于制备用于预防，治疗和诊断与蛋白质错折叠有关的CNS退行性病症的药物 和/或散乱。 本发明还涉及式（I）中包括的新化合物，涉及制备所述化合物的方法和含有它们的药物组合物。

    Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof
    9.
    发明申请
    Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof 有权
    抗生素107891，其因子A1和A2，药学上可接受的盐和组合物及其用途

    公开(公告)号：US20050203005A1

    公开(公告)日：2005-09-15

    申请号：US11035296

    申请日：2005-01-12

    申请人： Ameriga Lazzarini ,  Luciano Gastaldo ,  Gianpaolo Candiani ,  Ismaela Ciciliato ,  Daniele Losi ,  Flavia Marinelli ,  Enrico Selva ,  Franco Parenti

    发明人： Ameriga Lazzarini ,  Luciano Gastaldo ,  Gianpaolo Candiani ,  Ismaela Ciciliato ,  Daniele Losi ,  Flavia Marinelli ,  Enrico Selva ,  Franco Parenti

    IPC分类号： A61K38/12 ,  C07K7/64

    CPC分类号： C07K14/37 ,  A61K38/00

    摘要： The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such as M. catharralis, Neisseria species and H. influenzae and Mycobacteria.

    摘要翻译： 本发明涉及微生物来源的抗生素物质，其是通过微生物种的发酵产生的任意计数的抗生素107891。 ATCC PTA-5024，其药学上可接受的盐和组合物，以及它们作为对易感微生物具有抑制活性的抗菌剂的用途。 抗生素107891是包含两个因子A1和A2的因子的复合物，其具有含有羊毛硫氨酸和甲基青蒿素作为组分的肽结构，它们是羊毛硫抗生素组抗生素的典型特征。 抗生素107891及其因子A1和A2对抗革兰氏阳性菌（包括甲氧西林抗性和万古霉素抗性菌株）具有良好的抗菌活性，并且还对一些革兰氏阴性细菌（例如M.catharralis，奈瑟氏球菌和流感嗜血杆菌和分枝杆菌 。