-
公开(公告)号：US08252902B2
公开(公告)日：2012-08-28
申请号：US10278364
申请日：2002-10-22
IPC分类号： C07K16/00
CPC分类号： A61K49/0058 , A61K47/54 , A61K47/545 , A61K47/642 , A61K47/66 , A61K47/6813 , A61K47/6871 , A61K47/6881 , A61K47/6889 , B82Y5/00 , C07D475/04 , C07K5/0817 , C07K7/06 , C07K14/005 , C07K14/47 , C07K14/5406 , C07K14/575 , C07K14/71 , C07K16/40 , C12N9/0002 , C12N15/115 , C12N2740/16022
摘要： The present invention provides antibody targeting compounds in which the specificity of the antibody has been reprogrammed by covalently or noncovalently linking a targeting agent to the combining site of an antibody. By this approach, the covalently modified antibody takes on the binding specificity of the targeting agent. The compound may have biological activity provided by the targeting agent or by a separate biological agent. Various uses of the invention compounds are provided.
摘要翻译： 本发明提供抗体靶向化合物，其中抗体的特异性已通过共价或非共价连接靶向剂与抗体的结合位点重新编程。 通过这种方法，共价修饰的抗体具有靶向剂的结合特异性。 化合物可以具有由靶向剂或单独的生物制剂提供的生物活性。 提供本发明化合物的各种用途。
-
公开(公告)号：US06268488B1
公开(公告)日：2001-07-31
申请号：US09318661
申请日：1999-05-25
IPC分类号： C07H1524
CPC分类号： C07H15/252
摘要： The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
摘要翻译： 本发明提供了一种化合物，其包含与对具有后 - 醛醇缩合反应的分子的催化作用敏感的阻断部分连接的活性治疗剂和复合迈克尔催化活性，制备这种化合物的方法和将这些化合物转化为活性的方法 使用具有醛缩酶活性的分子的治疗剂。
-
公开(公告)号：US06677435B2
公开(公告)日：2004-01-13
申请号：US09883758
申请日：2001-06-18
IPC分类号： C07K1600
CPC分类号： C07H15/252
摘要： The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
摘要翻译： 本发明提供了一种化合物，其包含与对具有后 - 醛醇缩合反应的分子的催化作用敏感的阻断部分连接的活性治疗剂和复合迈克尔催化活性，制备这种化合物的方法和将这些化合物转化为活性 使用具有醛缩酶活性的分子的治疗剂。
-
公开(公告)号：US06342587B1
公开(公告)日：2002-01-29
申请号：US09425638
申请日：1999-10-22
IPC分类号： C07K1628
CPC分类号： C07K16/3046 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention is directed to novel CDRs and immunoglobulin products that bind to A33 antigens and methods for their use. The invention also involves a method for making humanized antibodies, using a rabbit as a host animal, and phage display library methodologies, and the antibodies themselves. The methodology is useful, for example, in generating humanized antibodies against molecules associated with cancer, such as A33, which is associated with colon cancer.
摘要翻译： 本发明涉及结合A33抗原的新型CDR和免疫球蛋白产物及其使用方法。 本发明还涉及使用兔作为宿主动物制造人源化抗体的方法，以及噬菌体展示文库方法以及抗体本身。 该方法可用于例如产生针对与癌症相关的分子的人源化抗体，例如与结肠癌相关的A33。
-
公开(公告)号：US07087409B2
公开(公告)日：2006-08-08
申请号：US10078757
申请日：2002-02-19
CPC分类号： C07K16/005 , C07K16/2848 , C07K16/464 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2319/00
摘要： A humanized murine antibody is provided. The amino acid sequences of a light chain complementarity determining region from a mouse antibody are grafted onto a human light chain, and a heavy chain complementarity determining region from a mouse antibody are grafted onto a human antibody heavy chain to produce libraries from which a humanized murine antibody having the desired specificity is selected.
-
6.发明授权Methods for reducing the effects of cancers that express A33 antigen using A33 antigen specific immunoglobulin products 失效使用A33抗原特异性免疫球蛋白产品降低表达A33抗原的癌症的作用的方法公开(公告)号：US06346249B1
公开(公告)日：2002-02-12
申请号：US09543004
申请日：2000-04-04
IPC分类号： A61K39395
CPC分类号： C07K16/3046 , A61K2039/505 , C07K16/00 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention is directed to methods of reducing the effects of cancer in a subject by administering to said subject a pharmaceutically effective amount of an anti-cancer agent conjugated to an inmmunoglobulin product which comprises one or more novel complementarity determining region and framework regions.
摘要翻译： 本发明涉及通过向所述受试者施用药学有效量的与包含一个或多个新的互补决定区和框架区的免疫球蛋白产物缀合的抗癌剂来减少受试者中癌症的影响的方法。
-
公开(公告)号：US09316646B2
公开(公告)日：2016-04-19
申请号：US13265582
申请日：2010-04-23
IPC分类号： C07K16/00 , G01N33/574 , A61K47/48 , C07K16/28 , A61K39/00
CPC分类号： G01N33/57492 , A61K47/6829 , A61K47/6849 , A61K2039/505 , C07K16/2857 , C07K2317/569 , G01N2333/705
摘要： The invention relates to antibodies having specificity for human ROR1, compositions thereof, and methods for using such antibodies, including in the diagnosis and treatment of disorders associated with aberrant ROR1 expression.
摘要翻译： 本发明涉及对人ROR1具有特异性的抗体，其组合物，以及使用此类抗体的方法，包括在诊断和治疗与异常ROR1表达相关的疾病中。
-
公开(公告)号：US09273136B2
公开(公告)日：2016-03-01
申请号：US13057092
申请日：2009-07-31
申请人： Christoph Rader , Ka Yin Kwong
发明人： Christoph Rader , Ka Yin Kwong
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要： The invention relates to isolated fully human monoclonal antibodies having specificity for human NKG2D and compositions thereof. The invention further relates to methods for using such antibodies in treating diseases or conditions such as cancer, autoimmune disease, or infectious disease.
摘要翻译： 本发明涉及对人NKG2D具有特异性的分离的完全人单克隆抗体及其组合物。 本发明还涉及使用这些抗体治疗疾病或病症如癌症，自身免疫疾病或感染性疾病的方法。
-
公开(公告)号：US20130251642A1
公开(公告)日：2013-09-26
申请号：US13990977
申请日：2011-11-30
申请人： Christoph Rader , Jiahui Yang
发明人： Christoph Rader , Jiahui Yang
IPC分类号： C07K16/28
CPC分类号： C07K16/2869 , C07K16/2857 , C07K2317/55 , C07K2317/624 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The invention relates to antibodies having specificity for human ROR1, compositions thereof, and methods for using such antibodies, including in the diagnosis and treatment of disorders associated with aberrant ROR1 expression.
摘要翻译： 本发明涉及对人ROR1具有特异性的抗体，其组合物，以及使用此类抗体的方法，包括在诊断和治疗与异常ROR1表达相关的疾病中。
-
公开(公告)号：US20130202622A1
公开(公告)日：2013-08-08
申请号：US13811712
申请日：2011-07-22
CPC分类号： A61K35/17 , A61K39/3955 , A61K2039/505 , C07K14/71 , C07K14/72 , C07K16/28 , C07K16/2803 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00 , C12N15/85 , C12N2740/15043
摘要： The present invention relates to therapeutic compositions for treating or preventing obesity and obesity-related disorders in a subject using immunotherapy to target and eliminate adipocytes.
摘要翻译： 本发明涉及使用免疫治疗来靶向和消除脂肪细胞的治疗或预防受试者中肥胖和肥胖相关疾病的治疗组合物。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.031 秒)
