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    Humanized immunoglobulins
    2.
    发明申请
    Humanized immunoglobulins 审中-公开
    人源化免疫球蛋白

    公开(公告)号：US20080160018A1

    公开(公告)日：2008-07-03

    申请号：US11603273

    申请日：2006-11-20

    申请人： Cary L. Queen ,  Man Sung Co ,  William P. Schneider ,  Nicholas F. Landolfi ,  Kathleen L. Coelingh ,  Harold E. Selick

    发明人： Cary L. Queen ,  Man Sung Co ,  William P. Schneider ,  Nicholas F. Landolfi ,  Kathleen L. Coelingh ,  Harold E. Selick

    IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P19/02 ,  A61P3/10

    CPC分类号： C07K16/087 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/088 ,  C07K16/249 ,  C07K16/2803 ,  C07K16/2866 ,  C07K16/2896 ,  C07K16/465 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30

    摘要： Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about 3 Å as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria. When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.

    摘要翻译： 提供了具有一个或多个互补决定区（CDR）和来自供体免疫球蛋白的可能的附加氨基酸和来自接受人免疫球蛋白的框架区的人源化免疫球蛋白的生产和组合物的新方法。 除了CDR之外，每个人源化免疫球蛋白链通常还包含来自供体免疫球蛋白框架的氨基酸，例如能够与CDR相互作用以产生结合亲和力，例如一个或多个氨基酸，其紧邻于 供体免疫球蛋白中的CDR或通过分子建模预测的那些。 重链和轻链各自可以通过使用各种位置标准中的任何一个或全部来设计。 当组合成完整的抗体时，本发明的人源化免疫球蛋白在人体中将基本上是非免疫原性的，并且保留与抗原例如含有表位的蛋白质或其它化合物基本上与供体免疫球蛋白相同的亲和力。

    Antibodies Against Mammalian Metapneumovirus
    4.
    发明申请
    Antibodies Against Mammalian Metapneumovirus 审中-公开
    针对哺乳动物亚型肺炎病毒的抗体

    公开(公告)号：US20100239585A1

    公开(公告)日：2010-09-23

    申请号：US12559015

    申请日：2009-09-14

    申请人： Nancy Ulbrandt ,  JoAnn Suzich ,  Kathleen L. Coelingh

    发明人： Nancy Ulbrandt ,  JoAnn Suzich ,  Kathleen L. Coelingh

    IPC分类号： A61K39/42 ,  C07K16/10 ,  A61P31/14

    CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention provides antibodies that immunospecifically bind to a polypeptide of a mammalian metapneumovirus, compositions comprising said antibodies, and methods for producing such antibodies. In particular, the invention provides monoclonal antibodies that immunospecifically bind to the F protein of human metapneumovirus and that neutralize human metapneumovirus. The invention also provides antibodies that cross-react with both the F protein of a mammalian metapneumovirus and the F protein of a mammalian respiratory syncytial virus and that neutralize both viruses. Further, the invention provides recombinant antibodies, such as humanized antibodies, against mammalian metapneumovirus, and methods for producing such recombinant antibodies. The invention further provides methods for treating, managing, ameliorating symptoms of and/or preventing infections with mammalian metapneumovirus, such as human metapneumovirus. The invention also provides antibodies that immunospecifically bind the F protein of avian pneumovirus. Antibodies that immunospecifically bind the F protein of avian pneumovirus are useful in the diagnosis and treatment of infections with avian pneumovirus.

    摘要翻译： 本发明提供了免疫特异性结合哺乳动物偏肺病毒多肽的抗体，包含所述抗体的组合物和用于产生此类抗体的方法。 特别地，本发明提供免疫特异性结合人类偏肺病毒的F蛋白并中和人间质肺病毒的单克隆抗体。 本发明还提供与哺乳动物偏肺病毒的F蛋白和哺乳动物呼吸道合胞病毒的F蛋白质交叉反应并且中和两种病毒的抗体。 此外，本发明提供针对哺乳动物偏肺病毒的重组抗体，例如人源化抗体，以及用于产生此类重组抗体的方法。 本发明还提供了用于治疗，控制，改善用哺乳动物偏肺病毒如人类偏肺病毒感染的症状和/或预防感染的方法。 本发明还提供免疫特异性结合禽肺病毒F蛋白的抗体。 免疫特异性结合禽肺炎病毒F蛋白的抗体可用于禽流感病毒感染的诊断和治疗。