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1.发明申请HETEROCYCLIC-SUBSTITUTED BENZOFURAN DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权杂环取代的苯唑嘌呤衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US20140199263A1
公开(公告)日：2014-07-17
申请号：US14343448
申请日：2012-08-16
申请人： Casey Cameron McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Zhong Lai , Qun Dang , Nicolas Zorn
发明人： Casey Cameron McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Zhong Lai , Qun Dang , Nicolas Zorn
IPC分类号： C07D513/04 , A61K31/497 , C07D405/14 , A61K31/4439 , C07D413/14 , A61K31/4245 , A61K31/444 , A61K31/506 , C07D498/04 , C07D417/14 , A61K31/5377 , A61K31/501 , A61K31/433 , C07D409/14 , A61K31/5365 , A61K31/5383 , C07F7/10 , A61K31/695 , A61K45/06 , C07D471/04
CPC分类号： A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/695 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04 , C07F7/10 , Y02A50/385 , Y02A50/387 , Y02A50/389 , A61K31/424 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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2.发明授权Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases 有权杂环取代的苯并呋喃衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US09549917B2
公开(公告)日：2017-01-24
申请号：US14343448
申请日：2012-08-16
申请人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Zhong Lai , Qun Dang , Nicolas Zorn
发明人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Zhong Lai , Qun Dang , Nicolas Zorn
IPC分类号： A61K45/06 , A61K31/506 , A61K31/444 , A61K31/443 , A61K31/497 , A61K31/501 , A61K31/695 , A61K31/424 , A61K31/4245 , A61K31/4439 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04 , A61K31/433 , A61K31/5365 , A61K31/5377 , A61K31/5383 , C07F7/10
CPC分类号： A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/695 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04 , C07F7/10 , Y02A50/385 , Y02A50/387 , Y02A50/389 , A61K31/424 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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3.发明授权Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases 有权四环杂环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US09265773B2
公开(公告)日：2016-02-23
申请号：US14343450
申请日：2012-08-20
申请人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Shuwen He , Xing Dai , Hong Liu , Zhong Lai , Clare London , Dong Xiao , Nicolas Zorn , Ravi Nargund
发明人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Shuwen He , Xing Dai , Hong Liu , Zhong Lai , Clare London , Dong Xiao , Nicolas Zorn , Ravi Nargund
IPC分类号： A61K31/553 , C07D491/052 , A61K31/519 , A61K31/407 , C07D498/22 , A61K31/437 , C07D491/147 , C07D498/14 , C07D498/04 , A61K31/5365 , A61K45/06
CPC分类号： A61K31/553 , A61K31/407 , A61K31/437 , A61K31/519 , A61K31/5365 , A61K45/06 , C07D491/052 , C07D491/147 , C07D498/04 , C07D498/14 , C07D498/22 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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4.发明授权Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases 有权取代的苯并呋喃化合物及其用于治疗病毒性疾病的方法公开(公告)号：US09573939B2
公开(公告)日：2017-02-21
申请号：US14343462
申请日：2012-08-16
申请人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Qun Dang
发明人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Qun Dang
IPC分类号： C07D405/04 , C07D405/14 , C07D487/04 , C07D471/04 , C07D473/00 , C07D498/04 , A61K45/06 , A61K31/416 , A61K31/52 , A61K31/437 , A61K31/4045 , A61K31/4184 , A61K31/4375 , A61K31/4439 , A61K31/4985 , A61K31/5025
CPC分类号： C07D405/04 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4985 , A61K31/5025 , A61K31/52 , A61K45/06 , C07D405/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D498/04 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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5.发明申请SUBSTITUED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权替代苯并呋喃化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20150246902A1
公开(公告)日：2015-09-03
申请号：US14343462
申请日：2012-08-16
申请人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Qun Dang
发明人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Qun Dang
IPC分类号： C07D405/04 , C07D473/00 , A61K31/52 , A61K45/06 , A61K31/437 , C07D487/04 , A61K31/4985 , A61K31/5025 , A61K31/4184 , C07D471/04
CPC分类号： C07D405/04 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4985 , A61K31/5025 , A61K31/52 , A61K45/06 , C07D405/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D498/04 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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6.发明授权Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C 有权四环杂环化合物及其用于治疗丙型肝炎的方法公开(公告)号：US09242998B2
公开(公告)日：2016-01-26
申请号：US14766491
申请日：2014-02-03
申请人： Shuwen He , Xing Dai , Anandan Palani , Ravi Nargund , Zhong Lai , Nicolas Zorn , Dong Xiao , Qun Dang , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
发明人： Shuwen He , Xing Dai , Anandan Palani , Ravi Nargund , Zhong Lai , Nicolas Zorn , Dong Xiao , Qun Dang , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
IPC分类号： C07D498/14 , A61K31/5365 , A61K31/5377 , A61K45/06
CPC分类号： C07D498/14 , A61K31/5365 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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7.发明授权Heterocyclic compounds and methods of use thereof for the treatment of hepatitis C 有权杂环化合物及其用于治疗丙型肝炎的方法公开(公告)号：US09549921B2
公开(公告)日：2017-01-24
申请号：US14897966
申请日：2014-06-19
申请人： Shuwen He , Zhong Lai , Xing Dai , Dong Xiao , Clare London , Nicolas Zorn , Ravi Nargund , Anandan Palani , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
发明人： Shuwen He , Zhong Lai , Xing Dai , Dong Xiao , Clare London , Nicolas Zorn , Ravi Nargund , Anandan Palani , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
IPC分类号： A61K31/454 , C07D487/04 , A61K31/498 , A61K31/4525 , A61K31/4545 , A61K31/5377 , A61K31/496 , A61K31/55 , A61K31/502 , A61K31/423 , A61K31/404 , A61K45/06 , C07D413/14 , C07D498/04 , C07D471/04 , C07D405/04 , C07D417/14 , C07D405/14 , C07D513/04 , C07D495/04
CPC分类号： A61K31/454 , A61K31/404 , A61K31/423 , A61K31/4525 , A61K31/4545 , A61K31/496 , A61K31/498 , A61K31/502 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.(I)
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的用途的式I化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产（I）
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8.发明申请HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C 有权杂环化合物及其用于治疗HEPATITIS C的方法公开(公告)号：US20160143895A1
公开(公告)日：2016-05-26
申请号：US14897966
申请日：2014-06-19
申请人： Shuwen He , Zhong Lai , Xing Dai , Dong Xiao , Clare London , Nicolas Zorn , Ravi Nargund , Anandan Palani , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
发明人： Shuwen He , Zhong Lai , Xing Dai , Dong Xiao , Clare London , Nicolas Zorn , Ravi Nargund , Anandan Palani , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
IPC分类号： A61K31/454 , A61K45/06 , A61K31/5377 , A61K31/423 , A61K31/496 , A61K31/404 , C07D405/04 , A61K31/4525 , C07D405/14 , C07D471/04 , A61K31/4545 , C07D498/04 , C07D417/14 , C07D495/04 , C07D413/14
CPC分类号： A61K31/454 , A61K31/404 , A61K31/423 , A61K31/4525 , A61K31/4545 , A61K31/496 , A61K31/498 , A61K31/502 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.(I)
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的用途的式I化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产（I）
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9.发明申请公开(公告)号：US20160136172A1
公开(公告)日：2016-05-19
申请号：US14898768
申请日：2014-06-19
申请人： Xing DAI , Hong LIU , Anandan PALANI , Shuwin HE , Ravi NARGUND , Dong XIAO , Nicolas ZORN , Qun DANG , Casey C. MCCOMAS , Xuanjia PENG , Peng LI , Richard SOLL
发明人： Xing Dai , Hong Liu , Anandan Palani , Shuwen He , Ravi Nargund , Dong Xiao , Nicolas Zorn , Qun Dang , Casey C. McComas , Xuanjia Peng , Peng Li , Richard Soll
IPC分类号： A61K31/5365 , C07D471/04 , A61K31/519 , C07D405/04 , A61K45/06 , C07D475/02 , A61K31/437 , A61K31/4725 , A61K31/53 , C07D405/14 , C07D498/04 , A61K31/517
CPC分类号： A61K31/5365 , A61K31/437 , A61K31/4725 , A61K31/517 , A61K31/519 , A61K31/53 , A61K45/06 , C07D405/04 , C07D405/14 , C07D471/04 , C07D475/02 , C07D498/04
摘要： The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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10.发明申请TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C 有权四环杂环化合物及其用于治疗乙型肝炎的方法公开(公告)号：US20150361101A1
公开(公告)日：2015-12-17
申请号：US14766462
申请日：2014-02-03
申请人： Xing DAI , Anandan PALANI , Shuwen HE , Linda L. BROCKUNIER , Ravi NARGUND , Karen MARCANTONO , Nicolas Zorn , Dong XIAO , Xuanjia PENG , Tao GUO , MERCK SHARP & DOHME CORP.
发明人： Xing Dai , Hong Liu , Anandan Palani , Shuwen He , Linda L. Brockunier , Ravi Nargund , Karen Marcantonio , Nicolas Zorn , Dong Xiao , Xuanjia Peng , Peng Li , Tao Guo
IPC分类号： C07D519/00 , C07D471/14 , A61K31/4375 , A61K31/5025 , A61K31/438 , A61K31/55 , C07D471/22 , C07D471/04 , C07D471/20 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/4375 , A61K31/438 , A61K31/444 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/14 , C07D471/20 , C07D471/22 , C07D487/14 , A61K2300/00
摘要： The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的用途的式I化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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