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    PTERIDINONES AS KINASE INHIBITORS
    4.
    发明申请
    PTERIDINONES AS KINASE INHIBITORS 审中-公开
    西替尼嗪作为激酶抑制剂

    公开(公告)号：US20070049600A1

    公开(公告)日：2007-03-01

    申请号：US11553935

    申请日：2006-10-27

    申请人： William Denny ,  Gordon Rewcastle ,  Ellen Dobrusin ,  James Kramer ,  Dennis McNamara ,  Howard Daniel Showalter ,  Peter Toogood

    发明人： William Denny ,  Gordon Rewcastle ,  Ellen Dobrusin ,  James Kramer ,  Dennis McNamara ,  Howard Daniel Showalter ,  Peter Toogood

    IPC分类号： C07D475/02 ,  A61K31/525

    CPC分类号： C07D475/00

    摘要： Disclosed are compounds of the formula wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The present invention also provides a method of treating cell proliferative disorders. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.

    摘要翻译： 公开了下式的化合物其中：W是NH，S，SO或SO 2; R 2是（未）取代的芳基，（未）取代的杂芳基或（取代的）取代的碳环或杂环; Q是氢或低级烷基; R 4和R 6相同或不同，表示氢，卤素，低级烷基，低级烷氧基，（未）取代的芳基，（未）取代的杂芳基，（un ）取代的芳基烷基或（未）取代的杂芳基烷基; 和R 8是氢，低级烷基或含有3-7个成员的（未）取代的碳环，其中至多两个成员任选是选自氧和氮的杂原子; 或（R 8）是（un）取代的芳基，（未）取代的杂芳基，（未）取代的芳基烷基或（未）取代的杂芳基烷基。 这些化合物可用于治疗细胞增殖性疾病，如癌症和再狭窄。 这些化合物是细胞周期蛋白依赖性激酶（cdks）和生长因子介导的激酶的有效抑制剂。 本发明还提供了治疗细胞增殖性疾病的方法。 本发明还提供了含有式I化合物的药学上可接受的组合物。

    Edge smoothness with low resolution projected images for use in solid imaging
    5.
    发明申请
    Edge smoothness with low resolution projected images for use in solid imaging 有权
    具有低分辨率投影图像的边缘平滑度，用于固体成像

    公开(公告)号：US20060239588A1

    公开(公告)日：2006-10-26

    申请号：US11096748

    申请日：2005-04-01

    申请人： Charles Hull ,  Jouni Partanen ,  Charles Sperry ,  Patrick Dunne ,  Suzanne Scott ,  Dennis McNamara ,  Chris Manners

    发明人： Charles Hull ,  Jouni Partanen ,  Charles Sperry ,  Patrick Dunne ,  Suzanne Scott ,  Dennis McNamara ,  Chris Manners

    IPC分类号： G06K9/36

    CPC分类号： B29C64/106 ,  B33Y10/00 ,  B33Y50/00 ,  B33Y50/02

    摘要： A solid imaging apparatus and method employing sub-pixel shifting in multiple exposures of the digitally light projected image of a cross-section of a three-dimensional object on a solidifiable liquid medium. The multiple exposures provide increased resolution, preserving image features in a three-dimensional object and smoothing out rough or uneven edges that would otherwise be occur using digital light projectors that are limited by the number of pixels in an image projected over the size of the image. Algorithms are used to select pixels to be illuminated within the boundary of each image projected in the cross-section being exposed.

    摘要翻译： 一种在可凝固的液体介质上的三维物体的横截面的数字光投影图像的多次曝光中采用子像素偏移的固体成像装置和方法。 多次曝光提供增加的分辨率，保持三维物体中的图像特征，并平滑粗糙或不均匀的边缘，否则将使用受图像大小投影的图像中的像素数量限制的数字投影仪发生 。 算法用于选择要在被暴露的横截面中投影的每个图像的边界内要照明的像素。

    Bubble-free cross-sections for use in solid imaging
    6.
    发明申请
    Bubble-free cross-sections for use in solid imaging 有权
    无气泡横截面用于固体成像

    公开(公告)号：US20060249884A1

    公开(公告)日：2006-11-09

    申请号：US11375917

    申请日：2006-03-15

    申请人： Jouni Partanen ,  Raymond Soliz ,  Dennis McNamara ,  Charles Sperry ,  Charles Hull

    发明人： Jouni Partanen ,  Raymond Soliz ,  Dennis McNamara ,  Charles Sperry ,  Charles Hull

    IPC分类号： B29C35/08 ,  B29C41/02

    CPC分类号： B29C64/135 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/00

    摘要： A solid imaging apparatus and method employing build material transfer means effective to transfer solidifiable liquid build material from a first side of a radiation transparent build material carrier to a receiving substrate without entrapping air bubbles in layers of transferred solidifiable liquid build material and to cleanly separate the solidified build material from the radiation transparent build material carrier as each layer is formed during the layerwise building of a three-dimensional object. An expandable membrane forming an arcuate dome and a reciprocatible flexible film are employed to effect transfer of the solidifiable liquid build material.

    摘要翻译： 一种使用构建材料转移装置的固体成像装置和方法，其有效地将可固化的液体构建材料从辐射透明构建材料载体的第一侧转移到接收基底，而不会在转移的可固化液体构建材料的层中夹带气泡，并且清洁地分离 当在三维物体的分层建造期间形成每个层时，来自辐射透明构建材料载体的固化的构建材料。 使用形成弓形圆顶和可互换柔性膜的可膨胀膜来实现可凝固的液体构建材料的转移。

    Material delivery system for use in solid imaging
    7.
    发明申请
    Material delivery system for use in solid imaging 有权
    用于固体成像的物料输送系统

    公开(公告)号：US20070257055A1

    公开(公告)日：2007-11-08

    申请号：US11416811

    申请日：2006-05-03

    申请人： Suzanne Scott ,  Charles Sperry ,  Dennis McNamara

    发明人： Suzanne Scott ,  Charles Sperry ,  Dennis McNamara

    IPC分类号： B67D5/16

    CPC分类号： B29C64/106 ,  B33Y30/00 ,  B33Y40/00

    摘要： A disposable liquid build material feed cartridge for use in a solid imaging apparatus and a method of dispensing build material for use in such an apparatus with a radiation transparent build material carrier. The disposable liquid build material feed cartridge recovers unused liquid material from the radiation transparent build material carrier and recycles it through a filter into a supply reservoir for reuse. A dispersing roller is employed to express any entrapping air bubbles in the solidifiable liquid build material that is dispensed onto the radiation transparent build material carrier prior to its being imaged.

    摘要翻译： 一种用于固体成像设备的一次性液体构建材料进料筒，以及用于分配用于具有辐射透明构建材料载体的这种设备中的构建材料的方法。 一次性液体构建材料进料筒从辐射透明构建材料载体回收未使用的液体材料，并将其通过过滤器再循环到供应储存器中以供重新使用。 分散辊用于在可凝固的液体构建材料中表达任何截留的气泡，其在成像之前被分配到辐射透明构建材料载体上。

    IMAGER AND METHOD FOR CONSISTENT REPEATABLE ALIGNMENT IN A SOLID IMAGING APPARATUS
    8.
    发明申请
    IMAGER AND METHOD FOR CONSISTENT REPEATABLE ALIGNMENT IN A SOLID IMAGING APPARATUS 有权
    在固体成像装置中一致重复对准的成像器和方法

    公开(公告)号：US20080231731A1

    公开(公告)日：2008-09-25

    申请号：US11856241

    申请日：2007-09-17

    申请人： Charles Hull ,  Jouni Partanen ,  Charles Sperry ,  Suzanne Scott ,  Dennis McNamara

    发明人： Charles Hull ,  Jouni Partanen ,  Charles Sperry ,  Suzanne Scott ,  Dennis McNamara

    IPC分类号： H04N5/217

    CPC分类号： B29C64/124 ,  B29C64/106 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02

    摘要： A solid imaging apparatus is provided that includes a replaceable cartridge containing a source of build material and an extendable and retractable flexible transport film for transporting the build material layer-by-layer from the cartridge to the surface of a build in an image plane. An operator using the device needs merely to remove a spent cartridge and replace it with a fresh cartridge to continue solid imaging virtually uninterrupted. The apparatus also includes the capability of withdrawing and inserting an imager without the operator having to perform a separate alignment step. A brush attached to the transport film and forming part of the cartridge provides for intra-layer removal of excess uncured build material. If desired, the apparatus can produce a fully reacted build. A high intensity UV source cures the build between layers. An injection molded build pad is designed to hold a build in an inverted position for improving the build. The invention also provides for tilting the build elevator to reduce air entrainment and for releasing the build from the image plane.

    摘要翻译： 提供了一种固体成像装置，其包括容纳建筑材料源的可替换盒，以及用于将构建材料逐层从盒移动到图像平面中的构建体的表面的可伸缩的柔性输送膜。 使用该设备的操作者仅仅需要移除用过的墨盒，并用新的墨盒更换墨盒，以便连续地实时成像。 该装置还包括在不需要执行单独对准步骤的情况下撤回和插入成像器的能力。 附着在运输薄膜上并形成墨盒的一部分的刷子可用于层内去除多余的未固化的建筑材料。 如果需要，该装置可以产生完全反应的构造。 高强度紫外线源固化层之间的构建。 注塑成型垫被设计成将构造保持在倒置位置以改善构造。 本发明还提供了使构建电梯倾斜以减少空气夹带和用于将构图从图像平面释放。

    Material delivery tension and tracking system for use in solid imaging
    9.
    发明申请
    Material delivery tension and tracking system for use in solid imaging 有权
    物料输送张力和跟踪系统用于固体成像

    公开(公告)号：US20070259066A1

    公开(公告)日：2007-11-08

    申请号：US11416812

    申请日：2006-05-03

    申请人： Charles Sperry ,  Dennis McNamara ,  Suzanne Scott

    发明人： Charles Sperry ,  Dennis McNamara ,  Suzanne Scott

    IPC分类号： B29C35/08

    CPC分类号： B29C64/135 ,  B33Y10/00 ,  B33Y30/00

    摘要： A solid imaging apparatus and method employing a radiation transparent build material carrier and a build material dispensing system that accurately controls the thickness of the transferred layer of solidifiable liquid build material to the radiation transparent build material carrier to achieve high resolution imaging in three-dimensional objects built using an electro-optical radiation source.

    摘要翻译： 一种使用辐射透明构建材料载体和构建材料分配系统的固体成像装置和方法，其将准确地控制可渗透液体构建材料的转移层的厚度控制到辐射透明构建材料载体，以在三维物体中实现高分辨率成像 使用电光辐射源构建。

    Method and apparatus for making foam-in-place cushions with selective distribution of foam
    10.
    发明申请
    Method and apparatus for making foam-in-place cushions with selective distribution of foam 有权
    用于制造具有泡沫选择性分布的就地放置衬垫的方法和设备

    公开(公告)号：US20070252298A1

    公开(公告)日：2007-11-01

    申请号：US11411708

    申请日：2006-04-26

    申请人： Charles Sperry ,  Suzanne Scott ,  Dennis McNamara ,  Vincent Piucci ,  Michael Schamel

    发明人： Charles Sperry ,  Suzanne Scott ,  Dennis McNamara ,  Vincent Piucci ,  Michael Schamel

    IPC分类号： B29C44/12

    CPC分类号： B29C44/184 ,  B29C44/467 ,  B29C44/60

    摘要： A method and apparatus for making a foam-in-place cushion in which a foam-forming composition is dispensed between two plastic film portions in a predetermined fashion to selectively control the distribution of the foam in the cushion. A foam dispenser can be moved in a transverse direction as foam is dispensed. A dispersion device can be employed to apply pressure on predetermined areas of the film portions towards each other so as to cause the composition to be redistributed in position in a predetermined manner while the composition is in a less than fully expanded state. The plastic film can then be sealed closed to form an expanding foam cushion that can be placed into a shipping carton where the cushion expands to fill void space, or into a mold where the cushion expands and is molded into a desired shape.

    摘要翻译： 一种用于制造泡沫就座垫的方法和装置，其中泡沫形成组合物以预定方式分配在两个塑料膜部分之间，以选择性地控制泡沫在垫中的分布。 当分配泡沫时，泡沫分配器可以在横向移动。 可以使用分散装置来将胶片部分的预定区域朝向彼此施加压力，以便使组合物以预定方式重新分布在适当位置，同时组合物处于小于完全展开状态。 然后可以将塑料膜密封封闭以形成膨胀的泡沫垫，其可以放置在运输纸箱中，其中衬垫膨胀以填充空隙空间，或者放入垫中膨胀并被模制成所需形状的模具中。