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公开(公告)号：US11542492B2
公开(公告)日：2023-01-03
申请号：US15423115
申请日：2017-02-02
申请人： Celgene CAR LLC
发明人： Russell C. Petter , Charles F. Jewell , Kwangho Lee , Aravind Prasad Medikonda , Deqiang Niu , Lixin Qiao , Juswinder Singh , Zhendong Zhu
IPC分类号： C12N9/96 , G16B15/00 , C07D405/14 , C07D491/08 , C07D487/04 , C07D495/04 , G01N33/68 , C07D519/00 , C07D401/04 , C07D403/12 , C07D405/12 , C07D417/14 , C07D207/16 , C07D417/06 , C07D493/04 , C07D409/12 , C07D401/14 , C07D239/49 , C07D513/04 , G16C20/50 , G16B15/30 , C07D403/14 , C12N9/12 , C12N9/50 , C12N9/00 , C12Q1/25 , C12Q1/37 , C12Q1/48
摘要： The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
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公开(公告)号：US20210017137A1
公开(公告)日：2021-01-21
申请号：US16797776
申请日：2020-02-21
申请人： Celgene CAR LLC
IPC分类号： C07D239/48 , C07C55/02 , C07C55/07 , C07C62/02 , C07C309/04 , C07C309/05 , C07C309/27 , C07C309/29 , C07C309/30 , C07C309/35
摘要： The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.
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公开(公告)号：US10434101B2
公开(公告)日：2019-10-08
申请号：US15869635
申请日：2018-01-12
申请人： Celgene CAR LLC
IPC分类号： A61K31/506 , A61K31/551 , A61K31/541 , A61K31/5377 , C07D403/14 , C07D239/47 , C07D239/42 , C07D239/34 , C07D239/48
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号：US20170217904A1
公开(公告)日：2017-08-03
申请号：US15401637
申请日：2017-01-09
申请人： Celgene CAR LLC
IPC分类号： C07D239/48 , C07C309/27 , C07C309/05 , C07C62/02 , C07C309/04 , C07C309/35 , C07C55/07 , C07C309/30 , C07C309/29 , C07C55/02
CPC分类号： C07D239/48 , C07B2200/13 , C07C55/02 , C07C55/07 , C07C62/02 , C07C309/04 , C07C309/05 , C07C309/27 , C07C309/29 , C07C309/30 , C07C309/35
摘要： The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.
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公开(公告)号：US20220218704A1
公开(公告)日：2022-07-14
申请号：US17445539
申请日：2021-08-20
申请人： Celgene CAR LLC
IPC分类号： A61K31/506 , C07D403/14 , C07D239/34 , C07D239/42 , C07D239/48 , C07D239/47 , A61K31/5377 , A61K31/541 , A61K31/551
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号：US20180353508A1
公开(公告)日：2018-12-13
申请号：US15869635
申请日：2018-01-12
申请人： Celgene CAR LLC
IPC分类号： A61K31/506 , A61K31/551 , A61K31/541 , A61K31/5377 , C07D403/14 , C07D239/47 , C07D239/42 , C07D239/34 , C07D239/48
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D403/14
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号：US10005738B2
公开(公告)日：2018-06-26
申请号：US15401637
申请日：2017-01-09
申请人： Celgene CAR LLC
IPC分类号： C07D239/49 , C07D239/48 , C07C55/02 , C07C55/07 , C07C62/02 , C07C309/04 , C07C309/05 , C07C309/27 , C07C309/29 , C07C309/30 , C07C309/35
CPC分类号： C07D239/48 , C07B2200/13 , C07C55/02 , C07C55/07 , C07C62/02 , C07C309/04 , C07C309/05 , C07C309/27 , C07C309/29 , C07C309/30 , C07C309/35
摘要： The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.
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公开(公告)号：US09765038B2
公开(公告)日：2017-09-19
申请号：US14996874
申请日：2016-01-15
申请人： Celgene CAR LLC
发明人： Kwangho Lee , Deqiang Niu , Russell C. Petter , Juswinder Singh
IPC分类号： A61K31/505 , A61K31/16 , A61K31/506 , A61K45/06 , C07D239/47 , C07D239/48
CPC分类号： C07D239/48 , A61K31/16 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/47 , A61K2300/00
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号：US11292772B2
公开(公告)日：2022-04-05
申请号：US16797776
申请日：2020-02-21
申请人： Celgene CAR LLC
IPC分类号： C07D239/48 , C07C55/02 , C07C55/07 , C07C62/02 , C07C309/04 , C07C309/05 , C07C309/27 , C07C309/29 , C07C309/30 , C07C309/35
摘要： The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.
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公开(公告)号：US10570099B2
公开(公告)日：2020-02-25
申请号：US16015626
申请日：2018-06-22
申请人： Celgene CAR LLC
IPC分类号： C07D239/48 , C07C55/02 , C07C55/07 , C07C62/02 , C07C309/04 , C07C309/05 , C07C309/27 , C07C309/29 , C07C309/30 , C07C309/35
摘要： The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.
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