公开(公告)号：US20130059308A1

公开(公告)日：2013-03-07

申请号：US13696139

申请日：2011-04-01

Applicant: Olga V. Makarova ,  Cha-Mei Tang ,  Platte T. Amstutz

Inventor： Olga V. Makarova ,  Cha-Mei Tang ,  Platte T. Amstutz

IPC: B01D39/16 ,  C12N5/09 ,  G03F7/20 ,  C12Q1/68 ,  G01N33/574 ,  B32B38/00 ,  C12Q1/24

CPC classification number: B41F33/0081 ,  B31B50/006 ,  B31B50/88 ,  B31B2100/0022 ,  B41F33/0036

Abstract: A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defmed by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate.

Abstract translation: 一种包含由环氧基可光定影干膜形成的聚合物层的微过滤器，以及遍及聚合物层的多个孔。 还公开了一种形成微过滤器的方法。 该方法包括提供设置在基底上的第一层环氧基光可定义干膜，通过掩模将第一层暴露于能量以形成在第一层干膜中由掩模定义的图案， 从曝光的第一层干膜，具有延伸穿过其中的多个孔的聚合物层，所述多个孔具有由图案限定的分布，以及从基底去除聚合物层。

公开(公告)号：US20100002981A1

公开(公告)日：2010-01-07

申请号：US12494152

申请日：2009-06-29

Applicant: Cha-Mei Tang ,  Platte T. Amstutz, III

Inventor： Cha-Mei Tang ,  Platte T. Amstutz, III

IPC: G02B6/00 ,  G01N21/00

CPC classification number: G01N21/0303 ,  G01N21/255 ,  G01N21/645 ,  G01N2021/6473

Abstract: A method of detecting fluorescence/absorbance/luminescence from 24-well, 48-well, 96-well, 384-well and 1536-well microplates and other sample containers. The sample is pumped into a waveguide. The waveguide efficiently gathers and guides the emission light to the end of the waveguide. The emission light exits the ends of the waveguide and is focused into a detector. To minimize background caused by the excitation light used for fluorescence, the excitation illuminates the waveguides at 90 degrees. To facilitate reuse, the waveguide assembly can be configured to be washed by an appropriate wash solution.

Abstract translation: 从24孔，48孔，96孔，384孔和1536孔微孔板和其他样品容器中检测荧光/吸光度/发光的方法。 将样品泵送到波导中。 波导有效地将发射光聚集并引导到波导的末端。 发射光离开波导的端部并聚焦到检测器中。 为了最小化用于荧光的激发光引起的背景，激发以90度照射波导。 为了便于重新使用，波导组件可以被配置为被适当的洗涤溶液洗涤。

公开(公告)号：US06272207B1

公开(公告)日：2001-08-07

申请号：US09251737

申请日：1999-02-18

Applicant: Cha-Mei Tang

Inventor： Cha-Mei Tang

IPC: G21K102

CPC classification number: G21K1/025

Abstract: An apparatus and method for obtaining a high-resolution digital image of an object or objects irradiated with radiation having a wavelength in the x-ray or gamma ray spectrum generated by a radiation source, or of an object or objects emitting radiation within the x-ray or gamma ray spectrum. The apparatus comprises a detector matrix and a radiation mask. The detector matrix comprises a plurality of detector pixels, each comprising a detection surface having a respective surface area which generates a signal in response to an energy stimulus. The radiation mask has an opaque portion, and a plurality of apertures. The aperture size and position relative to the detector array determines the image resolution not the size of the detector pixels. The mask is positioned between the detector matrix and the radiation source, such that the opaque portion prevents portions of the radiation from passing through the mask, and each of the apertures permits a portion of the radiation which has passed through or has been emitted from a respective portion of the object to propagate onto an area of the detection surface, less than the surface area, of a respective one of the detector pixels. The signal from a large detector pixel or from a group of small detector pixels represent an image of the respective portion of the object. The detector matrix and radiation mask are moved in synchronism in relation to the object to enable the areas of the detection surfaces of the detector pixels to receive portions of the radiation propagating through or emitted from other portions of the object, and to output signals representative of those other portions. These steps of moving the detector pixels and mask and irradiating the object are repeated until digital images of all portions of the object have been obtained. Alternatively, the x-ray source can be moved to image all portions of the object. The images are then arranged into an image representative of the entire object.

公开(公告)号：US5793152A

公开(公告)日：1998-08-11

申请号：US161667

申请日：1993-12-03

Applicant: Cha-Mei Tang ,  Thomas A. Swyden

Inventor： Cha-Mei Tang ,  Thomas A. Swyden

IPC: H01J3/02 ,  H01J19/24

CPC classification number: H01J3/022

Abstract: The present invention is a device for producing collimated electron beams. The device comprises a gated field emission array having at least one emission tip and a grid electrode having a grid opening disposed above the emission tip in a first direction. The device also comprises an integrated planar lens electrode for producing a focusing effect on electron beams emitted by the emission tip. The planar lens electrode has a lens edge disposed aside at a distance from the grid opening in a second direction perpendicular to the first direction. Preferably, the planar lens electrode is an integrated layer with the gated field emission array on a substrate. The grid electrode and the lens electrode can be on the same layer and separated by a gap of vacuum. The planar lens electrode can be above the grid electrode, separated by an insulative material. Similarly, the planar lens electrode can be below the grid electrode, and separated by an insulator material. Sometimes, the base electrode on which the tips are formed can act as a lens.

Abstract translation: 本发明是一种用于产生准直电子束的装置。 该装置包括具有至少一个发射尖端的栅控场发射阵列和在第一方向上布置在发射尖端上方的格栅的栅格电极。 该装置还包括用于产生对由发射尖端发射的电子束的聚焦效果的集成平面透镜电极。 平面透镜电极具有在垂直于第一方向的第二方向上与栅格开口一定距离的透镜边缘。 优选地，平面透镜电极是在基板上具有门控场致发射阵列的集成层。 栅格电极和透镜电极可以在同一层上，并通过真空间隙分离。 平面透镜电极可以在栅电极之上，由绝缘材料隔开。 类似地，平面透镜电极可以在栅电极之下，并被绝缘体材料分隔开。 有时，其上形成尖端的基极可以用作透镜。

公开(公告)号：US07922923B2

公开(公告)日：2011-04-12

申请号：US11984634

申请日：2007-11-20

Applicant: Cha-Mei Tang ,  Olga V. Makarova ,  Platte T. Amstutz, III ,  Guohua Yang

Inventor： Cha-Mei Tang ,  Olga V. Makarova ,  Platte T. Amstutz, III ,  Guohua Yang

IPC: B44C1/22 ,  C03C15/00 ,  C03C25/68

CPC classification number: G21K1/025

Abstract: Grids and collimators, for use with electromagnetic energy emitting devices, include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls. Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings extending entirely through the layer. At least some of the walls also can include projections extending into the respective openings formed by the walls. The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid at any distance from the edge. Methods to fabricate these grids using copper, lead, nickel, gold, any other electroplating/electroforming materials, metal composites or low melting temperature metals are described.

Abstract translation: 用于电磁能发射装置的网格和准直器至少包括通过例如电镀/电铸或铸造形成的金属层。 金属层包括顶表面和底表面，以及多个固体整​​体壁。 每个固体一体化壁从顶部到底部表面延伸并且具有多个侧表面。 固体一体化壁的侧表面布置成限定完全延伸穿过该层的多个开口。 至少一些壁还可以包括延伸到由壁形成的相应开口中的突起。 突起可以是各种形状和尺寸，并且被布置成使得沿着沿着栅格的边缘的方向传播的线相交的壁材的总量基本上与另一个与另一条线相交的壁材料的总量相同 在距离边缘任何距离处基本上平行于栅格的边缘的另一方向上传播。 描述了使用铜，铅，镍，金，任何其它电镀/电铸材料，金属复合材料或低熔点金属制造这些栅极的方法。

公开(公告)号：US07801394B2

公开(公告)日：2010-09-21

申请号：US11541785

申请日：2006-10-03

Applicant: Cha-Mei Tang ,  Platte T. Amstutz, III

Inventor： Cha-Mei Tang ,  Platte T. Amstutz, III

IPC: G02B6/32 ,  G02B6/42 ,  G02B6/00

CPC classification number: G01N21/0303 ,  G01N21/255 ,  G01N21/645

Abstract: A luminometer is provided comprising a waveguide sample holder and one or more detectors. The waveguide sample holder may include a hollow region to hold the sample. The waveguide sample holder can be made of material that guides emission light to a bottom end of the waveguide sample holder. One or more detectors may be provided which detect the emission light coming out of the bottom of the waveguide sample holder. A fluorometer/photometer is also provided that comprises a waveguide sample holder, one or more excitation light sources, and one or more optical detectors. The waveguide sample holder has a hollow region to hold the sample. The excitation light is introduced at an angle or perpendicular to one surface of the waveguide sample holder. The waveguide sample holder is made of material that can guide emission light to the bottom end of the waveguide sample holder. There are one or more detectors that detect the emission light coming out of the bottom of the waveguide sample holder.

Abstract translation: 提供了一种发光计，其包括波导样本保持器和一个或多个检测器。 波导样品保持器可以包括用于保持样品的中空区域。 波导样品保持器可以由将发射光引导到波导样品保持器的底端的材料制成。 可以提供一个或多个检测器，其检测从波导样品保持器的底部出来的发射光。 还提供了一种荧光计/光度计，其包括波导样品保持器，一个或多个激发光源和一个或多个光学检测器。 波导样品保持器具有用于保持样品的中空区域。 激发光以与波导样品保持器的一个表面成一定角度或垂直的方向引入。 波导样品架由能够将发射光引导到波导样品架的底端的材料制成。 存在一个或多个检测器，其检测从波导样品保持器的底部出来的发射光。

公开(公告)号：US07310411B2

公开(公告)日：2007-12-18

申请号：US11188210

申请日：2005-07-25

Applicant: Cha-Mei Tang ,  Olga V. Makarova

Inventor： Cha-Mei Tang ,  Olga V. Makarova

IPC: G21K1/00 ,  G21K1/02

CPC classification number: G21K1/025

Abstract: Grids and collimators, for use with electromagnetic energy emitting devices, include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls. Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings extending entirely through the layer. At least some of the walls also can include projections extending into the respective openings formed by the walls. The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid at any distance from the edge. Methods to fabricate these grids using copper, lead, nickel, gold, any other electroplating/electroforming materials or low melting temperature metals are described.

Abstract translation: 用于电磁能发射装置的栅格和准直器至少包括通过例如电镀/电铸或铸造形成的金属层。 金属层包括顶表面和底表面，以及多个固体整​​体壁。 每个固体一体化壁从顶部到底部表面延伸并且具有多个侧表面。 固体一体化壁的侧表面布置成限定完全延伸穿过该层的多个开口。 至少一些壁还可以包括延伸到由壁形成的相应开口中的突起。 突起可以是各种形状和尺寸，并且被布置成使得沿着沿着栅格的边缘的方向传播的线相交的壁材的总量基本上与另一个与另一条线相交的壁材料的总量相同 在距离边缘任何距离处基本上平行于栅格的边缘的另一方向上传播。 描述了使用铜，铅，镍，金，任何其它电镀/电铸材料或低熔点金属制造这些栅格的方法。

公开(公告)号：US20060068412A1

公开(公告)日：2006-03-30

申请号：US11074329

申请日：2005-03-04

Applicant: Cha-Mei Tang

Inventor： Cha-Mei Tang

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N33/54373 ,  B82Y15/00 ,  B82Y30/00

Abstract: The invention provides an integrated biosensor. The integrated bioprocessor consists of an integrated capture chamber having an analyte recognition coating and a structure supporting analyte detection, analyte growth and target nucleic acid detection. The integrated capture chamber can consist of a waveguide, a capillary tube, a mixing flow chamber or an integrated combination thereof. The integrated capture chamber also can contain an antibody or other recognition species as an analyte recognition coating, an illumination source, a radiation detector, a microfluidics handling system, a second chamber for target nucleic acid detection or a combination thereof. Also provided is an integrated biosensor. The integrated biosensor consists of an integrated capture chamber having an analyte recognition coating, an illumination source, a radiation detector and a structure supporting analyte detection, analyte growth and target nucleic acid detection. The integrated capture chamber can consist of a waveguide, a capillary tube, a mixing flow chamber or an integrated combination thereof. The integrated capture chamber also can contain an antibody as an analyte recognition coating, a microfluidics handling system, a second chamber for target nucleic acid detection or a combination thereof.

Abstract translation: 本发明提供一种集成的生物传感器。 集成的生物处理器由具有分析物识别涂层和支持分析物检测，分析物生长和靶核酸检测的结构的集成捕获室组成。 集成捕获室可以由波导，毛细管，混合流动室或其一体化组合组成。 集成捕获室还可以包含抗体或其他识别物质作为分析物识别涂层，照射源，放射线检测器，微流体处理系统，用于靶核酸检测的第二室或其组合。 还提供了一个集成的生物传感器。 集成生物传感器由具有分析物识别涂层，照明源，辐射检测器和支持分析物检测，分析物生长和靶核酸检测的结构的集成捕获室组成。 集成捕获室可以由波导，毛细管，混合流动室或其一体化组合组成。 集成捕获室还可以含有抗体作为分析物识别涂层，微流体处理系统，用于靶核酸检测的第二室或其组合。

公开(公告)号：US20100208256A1

公开(公告)日：2010-08-19

申请号：US11541785

申请日：2006-10-03

Applicant: Cha-Mei Tang ,  Platte T. Amstutz, III

Inventor： Cha-Mei Tang ,  Platte T. Amstutz, III

IPC: G01N21/01 ,  G01N21/00 ,  G01J3/28 ,  G01J1/58

CPC classification number: G01N21/0303 ,  G01N21/255 ,  G01N21/645

Abstract: A luminometer is provided comprising a waveguide sample holder and one or more detectors. The waveguide sample holder may include a hollow region to hold the sample. The waveguide sample holder can be made of material that guides emission light to a bottom end of the waveguide sample holder. One or more detectors may be provided which detect the emission light coming out of the bottom of the waveguide sample holder. A fluorometer/photometer is also provided that comprises a waveguide sample holder, one or more excitation light sources, and one or more optical detectors. The waveguide sample holder has a hollow region to hold the sample. The excitation light is introduced at an angle or perpendicular to one surface of the waveguide sample holder. The waveguide sample holder is made of material that can guide emission light to the bottom end of the waveguide sample holder. There are one or more detectors that detect the emission light coming out of the bottom of the waveguide sample holder.

Abstract translation: 提供了一种发光计，其包括波导样本保持器和一个或多个检测器。 波导样品保持器可以包括用于保持样品的中空区域。 波导样品保持器可以由将发射光引导到波导样品保持器的底端的材料制成。 可以提供一个或多个检测器，其检测从波导样品保持器的底部出来的发射光。 还提供了一种荧光计/光度计，其包括波导样品保持器，一个或多个激发光源和一个或多个光学检测器。 波导样品保持器具有用于保持样品的中空区域。 激发光以与波导样品保持器的一个表面成一定角度或垂直的方向引入。 波导样品架由能够将发射光引导到波导样品架的底端的材料制成。 存在一个或多个检测器，其检测从波导样品保持器的底部出来的发射光。

公开(公告)号：US20100181288A1

公开(公告)日：2010-07-22

申请号：US12691407

申请日：2010-01-21

Applicant: Cha-Mei Tang ,  Olga V. Makarova ,  Mark A. Hoffbauer ,  Todd L. Williamson ,  Platte T. Amstutz

Inventor： Cha-Mei Tang ,  Olga V. Makarova ,  Mark A. Hoffbauer ,  Todd L. Williamson ,  Platte T. Amstutz

IPC: B44C1/22

CPC classification number: B01D67/0062 ,  B01D67/0034 ,  B01D67/0093 ,  B01D69/02 ,  B01D2323/38 ,  B01D2325/028 ,  B01D2325/26

Abstract: Micro- and nanofilters have a wide range of applications in many fields, including medical diagnostics, drug delivery, medical implants, and hemodialysis. Some issues that limit commercial application of current nanofilters in medicine are low pore density, non-uniform pore size, and the use of materials that are not biocompatible. A method is described to fabricate high porosity polymer and diamond micro- and nanofilters producing smooth, uniform and straight pores of high aspect ratio. Pore size, density, and shape can be predetermined with a high degree of precision by masks and controlled etch. The method combines energetic neutral atom beam lithography and a mask. This technology allows etching polymeric materials in a clean, well-controlled, and charge-free environment, making it very suitable for fabricating nanofilters and other components for biomedical applications.

Abstract translation: 微型和纳米过滤器在许多领域有广泛的应用，包括医疗诊断，药物输送，医疗植入物和血液透析。 限制当前纳米过滤器在医药中的商业应用的一些问题是低孔密度，不均匀孔径以及不能生物相容的材料的使用。 描述了一种制造高孔隙率聚合物和金刚石微米和纳米过滤器的方法，其产生高纵横比的光滑，均匀和直孔。 孔径，密度和形状可以通过掩模和受控蚀刻以高精确度预先确定。 该方法结合了高能中性原子束光刻和掩模。 该技术允许在干净，良好控制和无电荷环境中蚀刻聚合物材料，使其非常适合制造用于生物医学应用的纳米过滤器和其他部件。