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    Regulation of matrix metalloproteinases by PSP94 family members
    5.
    发明申请
    Regulation of matrix metalloproteinases by PSP94 family members 审中-公开
    PSP94家族成员调节基质金属蛋白酶

    公开(公告)号：US20050096273A1

    公开(公告)日：2005-05-05

    申请号：US10948229

    申请日：2004-09-24

    申请人： Chandra Panchal ,  Luc Daigneault ,  Robert Hawkins ,  Marcia Ruiz ,  Seema Garde

    发明人： Chandra Panchal ,  Luc Daigneault ,  Robert Hawkins ,  Marcia Ruiz ,  Seema Garde

    IPC分类号： A61K38/10 ,  A61K38/17 ,  A61K38/46 ,  A61K38/52 ,  A61K48/00 ,  A61P35/00 ,  C07H21/04 ,  C07K14/47 ,  C12N9/64 ,  C12Q1/68 ,  A61K38/54 ,  C12N9/99

    CPC分类号： A61K38/1709 ,  A61K38/10 ,  A61K38/17 ,  A61K38/46 ,  A61K38/52 ,  A61K48/00 ,  C07H21/04 ,  C07K14/47 ,  C12N9/64 ,  C12N9/6491 ,  C12Q1/68

    摘要： Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This regulation occurs on three levels; alteration of gene expression, activation of the latent zymogen and inhibition by the tissue inhibitors of metalloproteinases (TIMP). We report here a new agent that regulates the level of MMPs in patient. More particularly, members of the PSP94 family, when administered to patients having metastatic hormone resistant prostate cancer, promote a significant decrease in MMP plasma levels. The invention therefore relates to the use of a PSP94 family member for the treatment of a condition related to the activity or expression of MMPs.

    摘要翻译： 基质金属蛋白酶（MMP）在形态发生，血管生成，伤口愈合以及某些疾病如类风湿性关节炎，肿瘤浸润和转移中起重要作用。 认为MMP被多种细胞因子，生长因子，激素和佛波酯所调节。 这种规定发生在三个层次上 基因表达的改变，潜在酶原的活化和金属蛋白酶（TIMP）的组织抑制剂的抑制。 我们在这里报告一种调节患者MMPs水平的新药物。 更具体地说，PSP94家族的成员在给予具有转移性激素抵抗性前列腺癌的患者时促进MMP血浆水平的显着降低。 因此，本发明涉及PSP94家族成员用于治疗与MMP的活性或表达相关的病症的用途。