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公开(公告)号：US20090118748A1
公开(公告)日：2009-05-07
申请号：US12285468
申请日：2008-10-06
CPC分类号： A61B17/0643 , A61B2017/00004
摘要： A biocompatible fastener particularly well-suited for use in fundoplication procedures. In a preferred embodiment, the fastener is designed to break within the span of approximately three to six months after implantation and comprises a male portion and a female portion. The male portion includes a first base member, the first base member being generally flat and oval. A pair of male members are mounted on the bottom surface of the first base member, each male member comprising a cylindrical post extending downwardly from the bottom surface of the first base member and a conical head disposed at the bottom end of the post. The female portion includes a second base member, the second base member being generally flat and oval. A pair of sleeves are mounted on the top surface of the second base member and extend upwardly therefrom. Each sleeve defines a bore adapted to receive a head from a corresponding male member and has an inner flange formed thereon. The flange extends radially into the bore and is engageable with the head once the head has been inserted therepast so as to inhibit withdrawal of the head from the bore. Except for an outer coating on each of the two heads, the fastener is made entirely of a non-bioabsorbable material or a bioabsorbable material having a relatively slow degradation rate. By contrast, the outer coating is made of a bioabsorbable material having a relatively fast degradation rate. The thickness of the outer coating is appropriately selected so that degradation of the outer coating permits each head to be withdrawn past its flange after a desired period of time.
摘要翻译： 特别适用于开窗手术的生物相容紧固件。 在优选实施例中，紧固件被设计成在植入后大约三到六个月的跨度内断裂，并且包括阳部分和阴部分。 阳部分包括第一基底构件，第一基底构件大致平坦且椭圆形。 一对阳构件安装在第一基底构件的底表面上，每个阳构件包括从第一基底构件的底表面向下延伸的圆柱形柱和设置在柱的底端的锥形头。 阴部分包括第二基部构件，第二基部构件大致平坦且椭圆形。 一对套筒安装在第二基座构件的顶表面上并从其向上延伸。 每个套筒限定适于从相应的阳构件接收头部并具有形成在其上的内凸缘的孔。 一旦头部已经被插入到其中，凸缘径向延伸到孔中并且可以与头部接合，以便阻止头部从孔中取出。 除了两个头部中的每一个之外的外涂层，紧固件完全由非生物吸收材料或具有相对较慢降解速率的生物可吸收材料制成。 相比之下，外涂层由具有相对较快降解速率的生物可吸收材料制成。 适当地选择外涂层的厚度，使得外涂层的降解允许每个头部在所需的时间段之后被拉出超过其凸缘。
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公开(公告)号：US08043331B2
公开(公告)日：2011-10-25
申请号：US12285468
申请日：2008-10-06
CPC分类号： A61B17/0643 , A61B2017/00004
摘要： An embodiment of the invention includes a method of fastening together two tissue portions. The method may include positioning a medical device adjacent a region of tissue having two tissue portions. The medical device may include a male member and a female member having a first bioabsorbable material overlying one of a non-bioabsorbable material and a second bioabsorbable material. The first bioabsorbable material may have a first degradation rate, and the second bioabsorbable material may have a second degradation rate slower than the first degradation rate. The method may also include inserting the male member inside the female member so as to inhibit withdrawal of the male member from the female member with the two tissue portions between the male member and the female member.
摘要翻译： 本发明的实施例包括将两个组织部分紧固在一起的方法。 该方法可以包括将医疗装置定位在具有两个组织部分的组织的区域附近。 医疗装置可以包括阳构件和阴构件，其具有覆盖非生物可吸收材料和第二生物可吸收材料之一的第一生物可吸收材料。 第一生物可吸收材料可具有第一降解速率，并且第二生物可吸收材料可具有比第一降解速率慢的第二降解速率。 该方法还可以包括将阳构件插入阴构件内，以阻止阳构件从阳构件与阳构件和阴构件之间的两个组织部分退出。
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公开(公告)号：US07442201B2
公开(公告)日：2008-10-28
申请号：US10712966
申请日：2003-11-12
CPC分类号： A61B17/0643 , A61B2017/00004
摘要： A biocompatible fastener particularly well-suited for use in fundoplication procedures. In a preferred embodiment, the fastener is designed to break within the span of approximately three to six months after implantation and comprises a male portion and a female portion. The male portion includes a first base member, the first base member being generally flat and oval. A pair of male members are mounted on the bottom surface of the first base member, each male member comprising a cylindrical post extending downwardly from the bottom surface of the first base member and a conical head disposed at the bottom end of the post. The female portion includes a second base member, the second base member being generally flat and oval. A pair of sleeves are mounted on the top surface of the second base member and extend upwardly therefrom. Each sleeve defines a bore adapted to receive a head from a corresponding male member and has an inner flange formed thereon. The flange extends radially into the bore and is engageable with the head once the head has been inserted therepast so as to inhibit withdrawal of the head from the bore. Except for an outer coating on each of the two heads, the fastener is made entirely of a non-bioabsorbable material or a bioabsorbable material having a relatively slow degradation rate. By contrast, the outer coating is made of a bioabsorbable material having a relatively fast degradation rate. The thickness of the outer coating is appropriately selected so that degradation of the outer coating permits each head to be withdrawn past its flange after a desired period of time.
摘要翻译： 特别适用于开窗手术的生物相容紧固件。 在优选实施例中，紧固件被设计成在植入后大约三到六个月的跨度内断裂，并且包括阳部分和阴部分。 阳部分包括第一基底构件，第一基底构件大致平坦且椭圆形。 一对阳构件安装在第一基底构件的底表面上，每个阳构件包括从第一基底构件的底表面向下延伸的圆柱形柱和设置在柱的底端的锥形头。 阴部分包括第二基部构件，第二基部构件大致平坦且椭圆形。 一对套筒安装在第二基座构件的顶表面上并从其向上延伸。 每个套筒限定适于从相应的阳构件接收头部并具有形成在其上的内凸缘的孔。 一旦头部已经被插入到其中，凸缘径向延伸到孔中并且可以与头部接合，以便阻止头部从孔中取出。 除了两个头部中的每一个之外的外涂层，紧固件完全由非生物吸收材料或具有相对较慢降解速率的生物可吸收材料制成。 相比之下，外涂层由具有相对较快降解速率的生物可吸收材料制成。 适当地选择外涂层的厚度，使得外涂层的降解允许每个头部在所需的时间段之后被拉出超过其凸缘。
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公开(公告)号：US06692507B2
公开(公告)日：2004-02-17
申请号：US09935950
申请日：2001-08-23
IPC分类号： A61B1704
CPC分类号： A61B17/0643 , A61B2017/00004
摘要： An impermanent biocompatible fastener comprises a male portion and a female portion. The male portion includes a base member and a pair of male members. The male members extend downwardly from the base member, each male member comprising a post and a head disposed at the bottom end of the post. The female portion includes a base member and a pair of sleeves. The sleeves extend upwardly from the base member, each sleeve defining a bore adapted to receive a head from a corresponding male member and having an inner flange. The flange extends into the bore and is engageable with the head once the head has been inserted past the flange to inhibit withdrawal of the head from the bore. Except for a biodegradable outer coating on each of the two heads, the fastener is made entirely of a non-bioabsorbable material.
摘要翻译： 无永久生物相容性紧固件包括阳部分和阴部分。 阳部分包括基部构件和一对阳构件。 阳构件从基部构件向下延伸，每个阳构件包括柱和设置在柱的底端的头部。 阴部包括基部构件和一对套筒。 套筒从底座部件向上延伸，每个套筒形成适于从相应的阳件接收头部并具有内凸缘的孔。 一旦头部已经穿过凸缘，凸缘延伸到孔中并且可以与头部接合，以阻止头部从孔中取出。 除了两个头部中的每一个上的可生物降解的外涂层之外，紧固件完全由非生物可吸收材料制成。
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公开(公告)号：US07615041B2
公开(公告)日：2009-11-10
申请号：US10909692
申请日：2004-07-29
IPC分类号： A61B19/00
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2037 , A61J1/2065
摘要： A vial adapter suitable for use in transferring fluid from a vial to a needleless syringe, the vial having a top end sealed with a septum. According to one embodiment, the vial adapter comprises (a) a body, the body having a top end, a bottom end and an inner cavity, the inner cavity being dimensioned to receive the vial, with the bottom end of the body extending below the bottom end of the vial; (b) a needle-bearing member mounted within the body, the needle-bearing member comprising a hollow needle extending downwardly into the inner cavity of the body for puncturing the septum of a vial disposed in the inner cavity; (c) a luer-lock-bearing member mounted on the top end of the body, the luer-lock-bearing member comprising a top portion and a bottom portion separated by a radial wall, the top portion being a female luer-lock, the bottom portion including a tubular structure in fluid communication with the hollow needle; and (d) a valve disposed within the luer-lock-bearing member for controlling fluid flow from the bottom portion to the top portion, the valve being opened by attachment of the needleless syringe to the vial adapter.
摘要翻译： 适合用于将流体从小瓶转移到无针注射器的小瓶适配器，小瓶具有用隔垫密封的顶端。 根据一个实施例，小瓶适配器包括（a）主体，主体具有顶端，底端和内腔，内腔的尺寸被设计成接收小瓶，其中主体的底端延伸到 小瓶底端; （b）安装在所述主体内的滚针轴承部件，所述滚针轴承部件包括向下延伸到所述主体的内腔中的中空针，用于刺穿设置在所述内腔中的小瓶的隔膜; （c）安装在所述主体的顶端的鲁尔锁定轴承部件，所述鲁尔锁定轴承部件包括由径向壁分隔开的顶部部分和底部部分，所述顶部部分是阴路厄锁定部， 底部包括与空心针流体连通的管状结构; 以及（d）设置在所述鲁尔锁定轴承部件内用于控制从所述底部到所述顶部的流体流动的阀，所述阀通过将所述无针注射器连接到所述小瓶适配器来打开。
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公开(公告)号：US5718861A
公开(公告)日：1998-02-17
申请号：US484894
申请日：1995-06-07
申请人： Robert R. Andrews , William Edelman , Joseph A. Levendusky , Peter T. Majeski , Robert L. O'Brien
发明人： Robert R. Andrews , William Edelman , Joseph A. Levendusky , Peter T. Majeski , Robert L. O'Brien
CPC分类号： B29C55/22 , A61M1/1072 , A61M25/1029 , A61M25/1034 , B29C41/14 , A61M25/0045 , A61M25/10 , B29L2031/7542
摘要： A method of forming intra-aortic balloons includes forming a balloon blank having a sleeve section at its proximal end. To reduce the diameter of the sleeve section of the balloon, the sleeve section is stretched longitudinally by gripping a first portion of the balloon blank at the distal end of the sleeve section, gripping a second portion of the balloon blank at the opposite end of the sleeve section and moving at least one of the gripped portions away from the other so as to reduce the diameter of the sleeve section. A heating element is positioned within the sleeve section to relieve the stress in the sleeve after stretching, by heating the sleeve section. The sleeve section is then cooled in order to preserve the sleeve section in its reduced diameter state thereby forming an intra-aortic balloon having a balloon blank with a reduced diameter sleeve section.
摘要翻译： 形成主动脉内球囊的方法包括在其近端形成具有套筒部分的球囊坯料。 为了减小气囊的套筒部分的直径，通过在套筒部分的远端处抓住球囊坯料的第一部分来纵向地拉伸套管部分，在该套筒部分的相对端处抓住气球坯料的第二部分 套筒部分，并且将夹持部分中的至少一个远离另一个移动，以减小套筒部分的直径。 加热元件定位在套筒部分内，以通过加热套筒部分来拉伸拉伸后的套筒中的应力。 然后将套筒部分冷却以便将套管部分保持在其缩径状态，从而形成具有直径减小的套管部分的球囊坯料的主动脉内球囊。
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公开(公告)号：US08518682B2
公开(公告)日：2013-08-27
申请号：US12966711
申请日：2010-12-13
IPC分类号： C12N11/04
CPC分类号： C12N5/0012 , A61L27/3804 , A61L27/3839 , A61L27/58
摘要： A tissue engineering composition adapted for application to an interior surface of a body lumen of a patient. The composition comprises (a) a carrier medium that is adapted to flow and to stably adhere the composition to the body lumen and (b) microcapsules, which are dispersed within the carrier medium and which contain one or more living cells encapsulated within a coating that includes a biodegradable polymer. The composition promotes growth of the cells on the lumen surface subsequent to application of the composition to the lumen.
摘要翻译： 适用于患者体腔内表面的组织工程组合物。 组合物包含（a）适于流动和稳定地将组合物粘附到体腔的载体介质和（b）微胶囊，其分散在载体介质中并且包含一个或多个包封在涂层内的活细胞， 包括可生物降解的聚合物。 组合物在将组合物施用于内腔后促进细胞在内腔表面上的生长。
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公开(公告)号：US20120310154A1
公开(公告)日：2012-12-06
申请号：US13588007
申请日：2012-08-17
CPC分类号： A61M5/2033 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B18/18 , A61B2010/0208 , A61B2017/00296 , A61B2017/0034 , A61B2017/00827 , A61B2017/306 , A61B2018/00291 , A61B2018/1425 , A61B2018/1495 , A61M5/14 , A61M5/30
摘要： An apparatus for treating tissue of a mammalian body. In one embodiment, a spring mechanism is carried by first and second tubular members and actuatable for moving a needle from a first position disposed within the distal extremity of the first tubular member to a second position extending distally of the first tubular member. In another embodiment, a nozzle is coupled to the distal extremity of an elongate tubular member for delivering a material into tissue of the mammalian body. In a further embodiment, a flexible elongate member provided with a recess is introduced into a cavity of the body to capture tissue in the recess and electrical energy is applied to such tissue in the recess so as to change the compliance of the tissue.
摘要翻译： 一种用于治疗哺乳动物体的组织的装置。 在一个实施例中，弹簧机构由第一和第二管状构件承载并且可致动以将针从设置在第一管状构件的远端中的第一位置移动到向第一管状构件的远侧延伸的第二位置。 在另一个实施例中，喷嘴连接到细长管状构件的远端，用于将材料输送到哺乳动物身体的组织中。 在另一个实施例中，设置有凹部的柔性细长构件被引入到身体的空腔中以捕获凹部中的组织，并且将电能施加到凹部中的这种组织，以便改变组织的顺应性。
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9.发明申请BIPOLAR ABLATION PROBE HAVING POROUS ELECTRODES FOR DELIVERING ELECTRICALLY CONDUCTIVE FLUID 审中-公开具有用于输送电导流体的多孔电极的双极性吸收探针公开(公告)号：US20080103494A1
公开(公告)日：2008-05-01
申请号：US11925624
申请日：2007-10-26
IPC分类号： A61B18/14
CPC分类号： A61B18/1482 , A61B2018/00065 , A61B2018/00577 , A61B2018/00589 , A61B2018/1472 , A61B2218/002
摘要： A tissue ablation probe comprises an elongated probe shaft, at least one fluid perfusion lumen longitudinally extending through the probe shaft, and a plurality of electrodes carried by the distal end of the probe shaft. Each of the electrodes includes a porous structure in fluid communication with the at least one perfusion lumen. The electrodes have a substantially co-extensive surface.
摘要翻译： 组织消融探针包括细长的探针轴，至少一个流体灌注腔，其纵向延伸穿过探针轴，以及由探头轴的远端承载的多个电极。 每个电极包括与至少一个灌注腔流体连通的多孔结构。 电极具有基本上共同的表面。
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公开(公告)号：US5865721A
公开(公告)日：1999-02-02
申请号：US658386
申请日：1996-06-05
CPC分类号： B29C55/22 , A61M1/1072 , A61M25/1029 , A61M25/1034 , B29C41/14 , A61M25/0045 , A61M25/10 , B29L2031/7542
摘要： An intra-aortic balloon pump catheter includes an inner lumen formed by a thin walled superelastic metal alloy tube, namely of nitinol, with an inside diameter sufficient for a guidewire and a small outside diameter which allows reduction of the outer lumen and related components by at least one size French while providing gas shuttle capacity between the lumens for conventional intra-aortic balloon pump operation. The outer lumen is a tube formed of co-extruded plastics to enhance the size reduction and capacity goals, with an inner nylon portion for strength and a relatively thin polyurethane outer portion for biocompatability, flexibility and compatibility for bonding to a thin polyurethane balloon. The proximal end sleeve of the balloon is stretched and then stress-relieved by heating with an internal heater on a mounting mandrel to effect a desired small diameter sizing. A radiopaque metal marker ring of nitinol also is provided to improve imaging capabilities while being compatible with the lumen materials.
摘要翻译： 主动脉内球囊泵导管包括由薄壁超弹性金属合金管（即镍钛诺）形成的内腔，其具有足以用于导丝的内径和小的外径，其允许通过以下方式减少外腔和相关部件 至少一个尺寸的法国人，同时在传统的主动脉内球囊泵操作的腔之间提供气体穿梭能力。 外腔是由共挤塑料形成的管，以增强尺寸减小和容量目标，其具有用于强度的内部尼龙部分和用于生物相容性的相对薄的聚氨酯外部部分，用于粘合到薄的聚氨酯气球的柔性和相容性。 气囊的近端套筒被拉伸，然后通过用安装心轴上的内部加热器加热来减轻应力，以实现所需的小直径尺寸。 还提供镍钛诺的不透射线的金属标记环以提高成像能力，同时与管腔材料相容。
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