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    Placental isoferritins for the prognosis and diagnosis of immunosuppression
    1.
    发明授权
    Placental isoferritins for the prognosis and diagnosis of immunosuppression 失效
    胎盘异铁蛋白用于预后和诊断免疫抑制

    公开(公告)号：US5283177A

    公开(公告)日：1994-02-01

    申请号：US853462

    申请日：1992-03-18

    申请人： Chaya Moroz ,  S. Leslie Misrock

    发明人： Chaya Moroz ,  S. Leslie Misrock

    IPC分类号： G01N33/68 ,  G01N33/577

    CPC分类号： G01N33/68 ,  Y10S435/974

    摘要： Methods for the diagnosis and prognosis of immunosuppressive conditions are disclosed, involving the detection of a particular isoform of ferritin, placental ferritin (PLF), in patient samples such as sera or on peripheral blood lymphocytes. PLF is elevated in immunosuppressed patients at early stages of disease; by contrast, adult insoferritins are elevated at late stages of immunodeficiency. Depending upon the nature of the disease associated with the immunodeficiency, the elevated levels of PLF detected at early stages may remain elevated or diminish as disease progresses. Examples are described in which elevated levels of PLF were detected at very early stages of of HIV-infection. The elevated levels diminished as disease progressed from ARC to AIDS. By contrast, adult isoforms of ferritin became elevated at late stages of disease.

    摘要翻译： 公开了用于诊断和预测免疫抑制条件的方法，涉及在诸如血清或外周血淋巴细胞的患者样品中检测铁蛋白，胎盘铁蛋白（PLF）的特定同种型。 PLF在疾病早期的免疫抑制患者中升高; 相反，在免疫缺陷的晚期阶段，成年铁调素受体升高。 根据与免疫缺陷相关的疾病的性质，随着疾病进展，早期检测到的PLF水平升高或降低。 描述了在HIV感染的非常早期阶段检测到升高的PLF水平的实例。 随着疾病从ARC进展到艾滋病，升高的水平下降。 相比之下，铁蛋白的成年同种型在疾病晚期升高。

    Placental isoferritins for the prognosis and diagnosis of immunosuppression
    2.
    发明授权
    Placental isoferritins for the prognosis and diagnosis of immunosuppression 失效
    胎盘异铁蛋白用于预后和诊断免疫抑制

    公开(公告)号：US5571678A

    公开(公告)日：1996-11-05

    申请号：US30524

    申请日：1993-03-12

    申请人： Chaya Moroz ,  S. Leslie Misrock

    发明人： Chaya Moroz ,  S. Leslie Misrock

    IPC分类号： C07K16/18 ,  C07K16/30 ,  G01N33/574 ,  G01N33/68 ,  G01N33/53

    CPC分类号： G01N33/57415 ,  C07K16/18 ,  C07K16/3015 ,  C07K16/3061 ,  G01N33/57476 ,  G01N33/68 ,  G01N33/689 ,  Y10S435/974 ,  Y10S436/813

    摘要： Methods for the diagnosis and prognosis of immunosuppressive conditions are disclosed, involving the detection of a particular isoform of ferritin, placental ferritin (PLF), in patient samples such as sera or on peripheral blood lymphocytes. PLF is elevated in immunosuppressed patients at early stages of disease; by contrast, adult insoferritins are elevated at late stages of immunodeficiency. Depending upon the nature of the disease associated with the immunodeficiency, the elevated levels of PLF detected at early stages may remain elevated or diminish as disease progresses. Examples are described in which elevated levels of PLF were detected at very early stages of of HIV-infection. The elevated levels diminished as disease progressed from ARC to AIDS. By contrast, adult isoforms of ferritin became elevated at late stages of disease.

    摘要翻译： 公开了用于诊断和预测免疫抑制条件的方法，涉及在诸如血清或外周血淋巴细胞的患者样品中检测铁蛋白，胎盘铁蛋白（PLF）的特定同种型。 PLF在疾病早期的免疫抑制患者中升高; 相反，在免疫缺陷的晚期阶段，成年铁调素受体升高。 根据与免疫缺陷相关的疾病的性质，随着疾病进展，早期检测到的PLF水平升高或降低。 描述了在HIV感染的非常早期阶段检测到升高的PLF水平的实例。 随着疾病从ARC进展到艾滋病，升高的水平下降。 相比之下，铁蛋白的成年同种型在疾病晚期升高。

    Placental isoferritins for the prognosis and diagnosis of immunosuppression
    3.
    发明授权
    Placental isoferritins for the prognosis and diagnosis of immunosuppression 失效
    胎盘异铁蛋白用于预后和诊断免疫抑制

    公开(公告)号：US5120640A

    公开(公告)日：1992-06-09

    申请号：US689656

    申请日：1991-04-23

    申请人： Chaya Moroz ,  Sol L. Misrock

    发明人： Chaya Moroz ,  Sol L. Misrock

    IPC分类号： C07K16/18 ,  C07K16/30 ,  G01N33/574

    CPC分类号： C07K16/3061 ,  C07K16/18 ,  C07K16/3015 ,  G01N33/57415 ,  G01N33/57476

    摘要： Methods for diagnosis and prognosis of immunosuppressive conditions are disclosed, involving the detection of a particular isoform of ferritin, placental ferritin (PLF), in patient samples such as sera or on peripheral blood lymphocytes. PLF is elevated in immunosuppressed patients at early stages of disease; by contrast, adult insoferritins are elevated at late stages of immunodeficiency. Depending upon the nature of the disease associated with the immunodeficiency, the elevated levels of PLF detected at early stages may remain elevated or diminish as disease progresses. Examples are described in which elevated levels of PLF were detected at very early stages of of HIV-infection. The elevated levels diminished as disease progressed from ARC to AIDS. By contrast, adult isoforms of ferritin became elevated at late stages of disease.

    摘要翻译： 公开了免疫抑制条件的诊断和预后的方法，涉及在诸如血清或外周血淋巴细胞的患者样品中检测铁蛋白特异性同种型，胎盘铁蛋白（PLF）。 PLF在疾病早期的免疫抑制患者中升高; 相反，在免疫缺陷的晚期阶段，成年铁调素受体升高。 根据与免疫缺陷相关的疾病的性质，随着疾病进展，早期检测到的PLF水平升高或降低。 描述了在HIV感染的非常早期阶段检测到升高的PLF水平的实例。 随着疾病从ARC进展到艾滋病，升高的水平下降。 相比之下，铁蛋白的成年同种型在疾病晚期升高。

    DNA sequence encoding oncofetal ferritin protein
    4.
    发明授权
    DNA sequence encoding oncofetal ferritin protein 失效
    编码甲胎蛋白的DNA序列

    公开(公告)号：US07217686B1

    公开(公告)日：2007-05-15

    申请号：US09786867

    申请日：1999-09-08

    申请人： Chaya Moroz

    发明人： Chaya Moroz

    IPC分类号： A61K38/00

    CPC分类号： C07K14/79 ,  A61K38/00

    摘要： A DNA sequence coding for oncofetal ferritin 1 (OFF1) as well as an amino acid sequence encoded by the DNA sequence. Pharmaceutical compositions may be prepared comprising the above-sequences for treating various diseases, for facilitating transplantations and for treating pathological pregnancies.

    摘要翻译： 编码骨髓蛋白1（OFF1）的DNA序列以及由DNA序列编码的氨基酸序列。 可以制备药物组合物，其包含用于治疗各种疾病的上述顺序，便于移植和用于治疗病理性怀孕。