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公开(公告)号：US09795599B2
公开(公告)日：2017-10-24
申请号：US15074965
申请日：2016-03-18
申请人： ChemoCentryx, Inc.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jaroslaw Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： C07D405/04 , C07D405/14 , A61K31/4709 , C07D215/48 , A61K31/47
CPC分类号： A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US10786494B2
公开(公告)日：2020-09-29
申请号：US16150796
申请日：2018-10-03
申请人： CHEMOCENTRYX, INC.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jaroslaw Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： A61K31/47 , C07D215/48 , C07D405/04 , C07D405/14 , A61K31/4709
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US09340509B2
公开(公告)日：2016-05-17
申请号：US14557949
申请日：2014-12-02
申请人： ChemoCentryx, Inc.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jarek Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： C07D215/48 , C07D405/14 , C07D405/04
CPC分类号： A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
摘要翻译： 提供式（I）化合物，其可用于治疗至少部分由CCR6调节的疾病或病症：
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公开(公告)号：US10532051B2
公开(公告)日：2020-01-14
申请号：US14875506
申请日：2015-10-05
申请人： ChemoCentryx, Inc.
发明人： Karen Ebsworth , Yu Wang , Yibin Zeng , Penglie Zhang , Joanne Tan
IPC分类号： A61K31/502 , A61K31/4412 , A61K31/4709 , A61K31/517 , A61K31/415 , A61K31/5377 , A61K39/395 , C07K16/28 , A61P1/00
摘要： Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof. The method include administering to a subject with IBD a combination therapy containing a therapeutically effective amount of a chemokine receptor 9 (CCR9) inhibitor compound and a therapeutically effective amount of an anti-α4β7 integrin antibody such as vedolizumab. Also provided herein is a kit containing the CCR9 inhibitor compound and anti-α4β7 integrin antibody.
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公开(公告)号：US20160296508A1
公开(公告)日：2016-10-13
申请号：US15074965
申请日：2016-03-18
申请人： ChemoCentryx, Inc.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jarek Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： A61K31/47 , A61K31/4709
CPC分类号： A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US20150175547A1
公开(公告)日：2015-06-25
申请号：US14557949
申请日：2014-12-02
申请人： ChemoCentryx, Inc.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jarek Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： C07D215/48 , C07D405/14 , C07D405/04
CPC分类号： A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
摘要翻译： 提供式（I）化合物，其可用于治疗至少部分由CCR6调节的疾病或病症：
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公开(公告)号：US10117865B2
公开(公告)日：2018-11-06
申请号：US15709012
申请日：2017-09-19
申请人： CHEMOCENTRYX, INC.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jaroslaw Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/10 , C07D405/14
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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