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公开(公告)号：US08853365B2
公开(公告)日：2014-10-07
申请号：US13331422
申请日：2011-12-20
CPC分类号： A61K39/395 , A61K2039/505 , A61K2039/507 , C07K16/245 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：US08841417B2
公开(公告)日：2014-09-23
申请号：US13107439
申请日：2011-05-13
IPC分类号： A61K38/00 , C07K14/545 , C07K16/24 , A61K39/395 , A61K47/48 , A61K45/06 , G01N33/68
CPC分类号： C07K16/245 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/007 , A61K9/0085 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K47/6879 , C07K14/545 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , G01N2800/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/412 , Y02A50/463 , Y02A50/478 , Y02A50/481
摘要： Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.
摘要翻译： 结合IL-1α和IL-1和bgr的蛋白质 描述其用于治疗，预防和诊断IL-1相关疾病和用于检测IL-1α和IL-1和bgr的组合物和方法中的用途; 在细胞，组织，样品和组合物中。
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公开(公告)号：US20110142761A1
公开(公告)日：2011-06-16
申请号：US12905499
申请日：2010-10-15
IPC分类号： A61K39/395 , C07K16/24 , C12N9/96 , C12N15/13 , C12N15/63 , C12N1/00 , C12N1/21 , C12N1/11 , C12N5/00 , C12N5/04 , C12N1/15 , C12N1/19 , C12P21/00 , A61K49/00 , A61K38/21 , G01N33/53 , A61P29/00 , A61P37/00 , A61P19/02 , A61P3/00 , A61P1/00 , A61P17/00 , A61P31/00 , A61P35/00 , A61P11/00 , A61P9/00
CPC分类号： C07K16/245 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N9/96 , G01N2333/545
摘要： The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1β-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1β binding proteins of the invention are useful for detecting IL-1β and for inhibiting IL-1β activity, including in a human subject suffering from a disease or disorder in which IL-1β activity is detrimental.
摘要翻译： 本发明描述了IL-1和bgr 结合蛋白，包括结合IL-1和bgr的嵌合，CDR移植和人源化抗体。 本发明的结合蛋白对IL-1和bgr具有高亲和力; 并中和IL-1和bgr; 活动。 本发明的结合蛋白可以是全长抗体或其IL-1结合部分。 还描述了制备方法和使用本发明的结合蛋白的方法。 IL-1和bgr 本发明的结合蛋白质可用于检测IL-1和bgr; 并用于抑制IL-1和bgr; 活动，包括在患有IL-1和bgr的疾病或病症的人类受试者中。 活动是有害的。
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公开(公告)号：US20130295004A1
公开(公告)日：2013-11-07
申请号：US13775540
申请日：2013-02-25
IPC分类号： C07K16/24 , A61K39/395 , A61K45/06 , C12N9/96
CPC分类号： C07K16/245 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N9/96 , G01N2333/545
摘要： The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1β-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1β binding proteins of the invention are useful for detecting IL-1β and for inhibiting IL-1β activity, including in a human subject suffering from a disease or disorder in which IL-1β activity is detrimental.
摘要翻译： 本发明描述了IL-1β结合蛋白，包括结合IL-1β的嵌合，CDR移植和人源化抗体。 本发明的结合蛋白对IL-1β具有高亲和力并中和IL-1β活性。 本发明的结合蛋白可以是全长抗体或其IL-1beta结合部分。 还描述了制备方法和使用本发明的结合蛋白的方法。 本发明的IL-1β结合蛋白可用于检测IL-1β和抑制IL-1β活性，包括在患有IL-1β活性有害的疾病或病症的人类受试者中。
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公开(公告)号：US08398966B2
公开(公告)日：2013-03-19
申请号：US12905499
申请日：2010-10-15
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/245 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N9/96 , G01N2333/545
摘要： The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1β-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1β binding proteins of the invention are useful for detecting IL-1β and for inhibiting IL-1β activity, including in a human subject suffering from a disease or disorder in which IL-1β activity is detrimental.
摘要翻译： 本发明描述了IL-1和bgr 结合蛋白，包括结合IL-1和bgr的嵌合，CDR移植和人源化抗体。 本发明的结合蛋白对IL-1和bgr具有高亲和力; 并中和IL-1和bgr; 活动。 本发明的结合蛋白可以是全长抗体或其IL-1结合部分。 还描述了制备方法和使用本发明的结合蛋白的方法。 IL-1和bgr 本发明的结合蛋白质可用于检测IL-1和bgr; 并用于抑制IL-1和bgr; 活动，包括在患有IL-1和bgr的疾病或病症的人类受试者中。 活动是有害的。
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6.发明申请ANTI-DLL4/VEGF DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF 有权ANTI-DLL4 / VEGF双变异型域免疫球蛋白及其用途公开(公告)号：US20140134172A1
公开(公告)日：2014-05-15
申请号：US14068976
申请日：2013-10-31
申请人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
发明人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC分类号： C07K16/28 , A61K45/06 , C07K16/22 , A61K39/395
CPC分类号： C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
摘要翻译： 本文公开了多价和多特异性结合蛋白，制备结合蛋白的方法及其在诊断，监测，抑制，预防和/或治疗癌症，肿瘤和/或其它血管发生依赖性疾病中的用途，其特征在于异常DLL4和 /或VEGF表达或活性。
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公开(公告)号：US09163093B2
公开(公告)日：2015-10-20
申请号：US14068976
申请日：2013-10-31
申请人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
发明人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC分类号： A61K39/395 , A61K39/40 , C07K16/46 , A61K45/06 , C07K16/22 , A61K31/513 , A61K31/7068 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/525 , C07K16/28 , C07K16/00 , A61K39/00
CPC分类号： C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
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