公开(公告)号：US08977360B2

公开(公告)日：2015-03-10

申请号：US13469990

申请日：2012-05-11

申请人： Chester Kim ,  Mun Pook Lui ,  Kerry Bradley

发明人： Chester Kim ,  Mun Pook Lui ,  Kerry Bradley

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/372

CPC分类号： A61N1/36071 ,  A61N1/36157 ,  A61N1/36185 ,  A61N1/37247

摘要： An external control device for use with a programmable implantable medical device coupled to an operative element. The external control device comprises a user interface comprising a control element and a display screen configured for displaying a graphical representation of the operative element. The external control device further comprises control circuitry configured for prompting the display screen to superimpose a graphical programmer control over the graphical representation of the operative element when the control element is actuated, and modifying an operational parameter for the operative element in response to actuation of the graphical programmer control. The external control device further comprises output circuitry configured for transmitting the modified operational parameter to the programmable implantable medical device.

摘要翻译： 一种用于与可操作元件耦合的可编程可植入医疗装置的外部控制装置。 外部控制装置包括用户界面，其包括控制元件和被配置为显示操作元件的图形表示的显示屏幕。 所述外部控制装置还包括控制电路，所述控制电路经配置以在所述控制元件被致动时提示所述显示屏幕将图形编程器控制叠加在所述操作元件的图形表示上，以及响应于所述操作元件的致动而修改所述操作元件的操作参数 图形编程器控制。 外部控制装置还包括被配置为将修改的操作参数传送到可编程可植入医疗装置的输出电路。

公开(公告)号：US20120290041A1

公开(公告)日：2012-11-15

申请号：US13469990

申请日：2012-05-11

申请人： Chester Kim ,  Mun Pook Lui ,  Kerry Bradley

发明人： Chester Kim ,  Mun Pook Lui ,  Kerry Bradley

IPC分类号： A61N1/36

CPC分类号： A61N1/36071 ,  A61N1/36157 ,  A61N1/36185 ,  A61N1/37247

摘要： An external control device for use with a programmable implantable medical device coupled to an operative element. The external control device comprises a user interface comprising a control element and a display screen configured for displaying a graphical representation of the operative element. The external control device further comprises control circuitry configured for prompting the display screen to superimpose a graphical programmer control over the graphical representation of the operative element when the control element is actuated, and modifying an operational parameter for the operative element in response to actuation of the graphical programmer control. The external control device further comprises output circuitry configured for transmitting the modified operational parameter to the programmable implantable medical device.

摘要翻译： 一种用于与可操作元件耦合的可编程可植入医疗装置的外部控制装置。 外部控制装置包括用户界面，其包括控制元件和被配置为显示操作元件的图形表示的显示屏幕。 所述外部控制装置还包括控制电路，所述控制电路经配置以在所述控制元件被致动时提示所述显示屏幕将图形编程器控制叠加在所述操作元件的图形表示上，以及响应于所述操作元件的致动而修改所述操作元件的操作参数 图形编程器控制。 外部控制装置还包括被配置为将修改的操作参数传送到可编程可植入医疗装置的输出电路。

公开(公告)号：US09511229B2

公开(公告)日：2016-12-06

申请号：US13533532

申请日：2012-06-26

申请人： Kerry Bradley

发明人： Kerry Bradley

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61B5/053 ,  A61N1/08 ,  A61B5/06

CPC分类号： A61N1/08 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/068 ,  A61N1/0551 ,  A61N1/36125 ,  A61N1/36182 ,  A61N1/37217 ,  A61N1/37241 ,  A61N1/3787

摘要： A method for implanting a neurostimulation lead within a patient includes measuring impedances of electrodes on the lead in order to correctly position the lead relative to a target tissue region. The electrodes are circumferentially segmented electrodes that are spaced from each other about the longitudinal axis of the lead. When the difference between the impedances of the electrodes exceeds a threshold value, the lead is in the correct position. In accordance with another embodiment, impedance measurements are used to select which one of the electrodes is closest to the target tissue region. By determining which electrode has the highest impedance and which electrode has the lowest impedance, the type of tissue adjacent to each electrode can be determined based on the conductivity properties of the tissue. The target tissue region may be a spinal cord, a posterior longitudinal ligament, white matter, or gray matter.

摘要翻译： 用于在患者体内植入神经刺激引线的方法包括测量引线上的电极的阻抗，以便使引线相对于目标组织区域正确定位。 电极是周向分段的电极，其围绕导线的纵向轴线彼此间隔开。 当电极的阻抗差超过阈值时，引线处于正确的位置。 根据另一个实施例，使用阻抗测量来选择哪个电极最靠近目标组织区域。 通过确定哪个电极具有最高阻抗并且哪个电极具有最低的阻抗，可以基于组织的电导率特性来确定与每个电极相邻的组织的类型。 目标组织区域可以是脊髓，后纵韧带，白质或灰质。

公开(公告)号：US09504818B2

公开(公告)日：2016-11-29

申请号：US12204170

申请日：2008-09-04

申请人： Michael Moffitt ,  Dongchul Lee ,  Kerry Bradley ,  David K. L. Peterson

发明人： Michael Moffitt ,  Dongchul Lee ,  Kerry Bradley ,  David K. L. Peterson

IPC分类号： A61N1/34 ,  A61N1/05 ,  A61N1/36

CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/36071

摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

公开(公告)号：US09352161B2

公开(公告)日：2016-05-31

申请号：US11553447

申请日：2006-10-26

申请人： James R. Thacker ,  Harold Haut ,  Robert Nathan ,  David K. L. Peterson ,  Kerry Bradley

发明人： James R. Thacker ,  Harold Haut ,  Robert Nathan ,  David K. L. Peterson ,  Kerry Bradley

IPC分类号： A61N1/372 ,  A61N1/36

CPC分类号： A61N1/37247 ,  A61N1/36071 ,  A61N1/36146 ,  A61N1/36171 ,  A61N1/36175

摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.

摘要翻译： 组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。 刺激脉冲可以由几个参数定义，例如脉冲宽度和幅度。 在用刺激系统刺激组织的方法中，用户可以调整诸如脉冲宽度的参数之一。 编程器可以响应于脉冲宽度的变化自动调节脉冲幅度，以便保持刺激脉冲的基本恒定的效果。

公开(公告)号：US08923974B2

公开(公告)日：2014-12-30

申请号：US13469880

申请日：2012-05-11

申请人： Kerry Bradley

发明人： Kerry Bradley

IPC分类号： A61N1/00 ,  A61N1/05 ,  A61N1/36

CPC分类号： A61N1/0551 ,  A61N1/36071

摘要： A method for treating a patient having discogenic pain includes implanting a neurostimulation lead within an anterior portion of the epidural space adjacent to the posterior longitudinal ligament. A plurality of electrodes is attached to the lead and the lead is implanted with at least a portion of the electrodes facing the posterior longitudinal ligament. The lead may be implanted in the lumbar region of the patient's spine, posterior and parallel to the posterior longitudinal ligament. Electrical stimulation energy applied to the patient through the electrode lead implanted in this manner inhibits the pain signals traveling within the posterior longitudinal ligament. Thus, the applied electrical stimulation energy has an anesthetic effect on the pain fibers adjacent to the posterior longitudinal ligament.

摘要翻译： 用于治疗具有椎间性疼痛的患者的方法包括将神经刺激引线植入在与后纵韧带相邻的硬膜外腔的前部中。 多个电极附接到引线，并且引线被注入，电极的至少一部分面向后纵向韧带。 铅可以植入患者脊柱的腰部区域，后部并且平行于后纵韧带。 通过以这种方式植入的电极引线施加到患者的电刺激能量抑制在后纵韧带内行进的疼痛信号。 因此，所施加的电刺激能量对与后纵韧带相邻的疼痛纤维具有麻醉作用。

公开(公告)号：US08718757B2

公开(公告)日：2014-05-06

申请号：US13367163

申请日：2012-02-06

申请人： Kerry Bradley ,  Sunil K. Kapoor

发明人： Kerry Bradley ,  Sunil K. Kapoor

IPC分类号： A61N1/00

CPC分类号： A61N1/37241 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/36185 ,  A61N2001/083

摘要： Apparatus and methods for detecting lead migration through the use of measured artifactual data about the tissue in the vicinity of the lead.

摘要翻译： 通过使用关于铅附近的组织的测量的人为因素来检测引线迁移的装置和方法。

公开(公告)号：US20120330391A1

公开(公告)日：2012-12-27

申请号：US13529906

申请日：2012-06-21

申请人： Kerry Bradley ,  Dongchul Lee

发明人： Kerry Bradley ,  Dongchul Lee

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/36067 ,  A61N1/36171 ,  A61N1/36175

摘要： A method for using spinal cord stimulation to treat symptoms of motor disorders includes implanting a stimulation lead within a ventral portion of the epidural space. The lead is implanted with at least a portion of the electrodes facing the spinal cord. In a method for providing therapy to a patient suffering from a motor disorder, electrical stimulation energy is applied to at least one ventral column nerve fiber through the implanted stimulation lead. A peripheral region of the patient's body exhibits the symptoms of the motor disorder, and the ventral column nerve fiber to which the stimulation is applied innervates that peripheral region.

摘要翻译： 使用脊髓刺激来治疗运动障碍症状的方法包括将刺激引线植入硬膜外腔的腹侧部分。 植入铅的至少一部分电极面向脊髓。 在向患有运动障碍的患者提供治疗的方法中，通过植入的刺激引线向至少一个腹侧神经纤维施加电刺激能量。 患者身体的周边区域表现出运动障碍的症状，并且施加刺激的腹侧柱神经纤维支配该外周区域。

公开(公告)号：US20100125315A1

公开(公告)日：2010-05-20

申请号：US12606065

申请日：2009-10-26

申请人： Jordi Parramon ,  David K.L. Peterson ,  Kerry Bradley ,  Rafael Carbunaru ,  Andrew DiGiore

发明人： Jordi Parramon ,  David K.L. Peterson ,  Kerry Bradley ,  Rafael Carbunaru ,  Andrew DiGiore

IPC分类号： A61N1/00

CPC分类号： A61N1/36125 ,  A61N1/0551 ,  A61N1/36157 ,  A61N1/36185

摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.

摘要翻译： 提供了向植入电极阵列的患者提供治疗的方法和系统。 电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动 分别与一个或多个电路径相关联。

公开(公告)号：US20100125314A1

公开(公告)日：2010-05-20

申请号：US12606050

申请日：2009-10-26

申请人： Kerry Bradley ,  Bradley Hershey ,  Dongchul Lee

发明人： Kerry Bradley ,  Bradley Hershey ,  Dongchul Lee

IPC分类号： A61N1/08

CPC分类号： A61N1/36192 ,  A61N1/36071 ,  A61N1/37247

摘要： A method of stimulating nerve tissue, a tissue stimulation system, and an external control device are provided. The method, system, and control device causes an electrical stimulus to be applied to at least one electrode adjacent the nerve tissue of a patient. The applied electrical stimulus comprises a plurality of pulses defined by a pulse width value and an amplitude value. The pulse amplitude value is increased (e.g., manually), and the pulse width value is automatically decreased in response to increasing the pulse amplitude value in a manner that increases the intensity of the applied electrical stimulus. Alternatively, the pulse width value may be decreased (e.g., manually), and the pulse amplitude value automatically increased in response to decreasing the pulse width value in a manner that increases the intensity of the applied electrical stimulus.

摘要翻译： 提供刺激神经组织，组织刺激系统和外部控制装置的方法。 该方法，系统和控制装置使得电刺激被施加到邻近患者神经组织的至少一个电极。 所施加的电刺激包括由脉冲宽度值和振幅值定义的多个脉冲。 脉冲幅度值增加（例如，手动），并且响应于以增加所施加的电刺激的强度的方式增加脉冲幅值来自动减小脉冲宽度值。 或者，可以减小脉冲宽度值（例如，手动地），并且响应于以增加所施加的电刺激的强度的方式减小脉冲宽度值，脉冲振幅值自动增加。