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    Free radical solution polymerization of vinylpyrrolidone
    3.
    发明授权
    Free radical solution polymerization of vinylpyrrolidone 失效
    乙烯基吡咯烷酮的自由基溶液聚合

    公开(公告)号：US5373074A

    公开(公告)日：1994-12-13

    申请号：US17155

    申请日：1993-02-12

    申请人： Chi-San Wu ,  James F. Curry ,  James P. Cullen

    发明人： Chi-San Wu ,  James F. Curry ,  James P. Cullen

    IPC分类号： C08F4/04 ,  C08F26/10 ,  C08F4/34 ,  C08F126/10

    CPC分类号： C08F26/10

    摘要： A free radical solution process for making PVP polymers having a molecular weight corresponding to a K-value of about 30-150, a narrow molecular weight distribution represented by a polydispersity of about 3 to 6, and a residual VP monomer level of less than 0.1%, which comprises:(a) precharging a reaction mixture of vinylpyrrolidone monomer and water in a solids contents w/w VP/H.sub.2 O of about 5-50%, and a dual free radical initiator system which comprises both low and high decomposition temperature free radical initiators whose 10-hour half-life temperature decomposition constants differ from each other by more than 5.degree. C., the low and high temperature initiators being present, respectively, in an amount of about 0.05-0.5%, and about 0.1-0.5%, by weight of the VP monomer,(b) polymerizing said monomer in said reaction mixture at a temperature near or above the 10-hour decomposition temperature of said low temperature initiator, and(c) after substantially all of the VP monomer has been converted to PVP polymer, continuing the polymerization at the same temperature as in (b), or at a higher temperature near or above the decomposition temperature of the high 10-hour temperature initiator, to complete the polymerization and to reduce the residual VP monomer level to less than 0.1%.

    摘要翻译： 一种自由基溶液法，其制备具有对应于约30-150的K值的分子量的PVP聚合物，由多分散性约3-6组成的窄分子量分布和小于0.1的残留VP单体水平 ％，其包括：（a）将乙烯基吡咯烷酮单体和水的反应混合物以约5-50％的固体含量w / w VP / H 2 O预充电，以及双重自由基引发剂体系，其包含低和高分解温度 其10小时半衰期温度分解常数彼此相差大于5℃的自由基引发剂，低温和高温引发剂分别以约0.05-0.5％和约0.1-0.5的量存在 （b）在所述反应混合物中的温度接近或高于所述低温引发剂的10小时分解温度的温度下聚合所述单体，和（c）在基本上所有的VP单体之后， 转化为PVP聚合物，在与（b）相同的温度下继续聚合，或在高10小时温度引发剂的分解温度附近或更高的温度下进行聚合，完成聚合并减少残留的VP单体 水平低于0.1％。

    Process for making narrow molecular weight distribution polyvinylpyrrolidone K-90 polymers
    4.
    发明授权
    Process for making narrow molecular weight distribution polyvinylpyrrolidone K-90 polymers 失效
    制备窄分子量分布聚乙烯吡咯烷酮K-90聚合物的方法

    公开(公告)号：US5338814A

    公开(公告)日：1994-08-16

    申请号：US51107

    申请日：1993-04-21

    申请人： Chi-San Wu ,  James F. Curry ,  James P. Cullen

    发明人： Chi-San Wu ,  James F. Curry ,  James P. Cullen

    IPC分类号： C08F2/04 ,  C08F26/10

    CPC分类号： C08F26/10

    摘要： A process for making polyvinylpyrrolidone (PVP) K-90 having a polydispersity of less than 6, preferably less than 5, and most preferably, less than 4, which comprises polymerizing vinylpyrrolidone monomer by free radical solution polymerization, in water, in the presence of polyethylene glycol (PEG) having a molecular weight of about 300 as a chain transfer agent. The product is an aqueous solution of 15-25% PVP K-90, preferably 20%, 15-30% PEG, preferably 25%, and 45-70% water, preferably 55%, by weight of the solution.

    摘要翻译： 一种多分散性小于6，优选小于5，最优选小于4的聚乙烯吡咯烷酮（PVP）K-90的方法，其包括通过自由基溶液聚合将乙烯基吡咯烷酮单体在水中，在水中存在下， 分子量约300的聚乙二醇（PEG）作为链转移剂。 该产品是15-25％PVP K-90，优选20％，15-30％PEG，优选25％和45-70％水，优选55％重量的该溶液的水溶液。

    Composition of an active component and free flowing particles of a polysaccharide matrix having significantly improved water dispersibility and stability in aqueous solutions
    6.
    发明授权
    Composition of an active component and free flowing particles of a polysaccharide matrix having significantly improved water dispersibility and stability in aqueous solutions 失效
    活性组分和自由流动的多糖基质颗粒的组成，其具有显着改善的水分散性和在水溶液中的稳定性

    公开(公告)号：US06096345A

    公开(公告)日：2000-08-01

    申请号：US10642

    申请日：1998-01-22

    申请人： Kolazi S. Narayanan ,  Ronald H. Goehner, Jr. ,  James F. Curry

    发明人： Kolazi S. Narayanan ,  Ronald H. Goehner, Jr. ,  James F. Curry

    IPC分类号： A61K9/16 ,  A01N25/14 ,  A61K9/14 ,  A61K47/32

    CPC分类号： A61K9/1635 ,  A61K9/1652 ,  Y10T428/2982

    摘要： This invention relates to a composition containing an active chemical and a particulate polysaccharide matrix having improved water dispersibility and dispersion stability in aqueous solutions by the incorporation of a copolymer of a N-vinyl lactam monomer and a hydrophobic comonomer. The improved properties of the matrix promotes its use as a dispersing agent in a wide variety of formulations where soil and skin substantivity or sustained release of the active chemical is required, as in pharmaceutical, pre- and post-emergent agrochemical and cosmetic formulations. The invention also pertains to the preparation and use of formulations based on the use of polysaccharide/copolymer matrix of this invention.

    摘要翻译： 本发明涉及一种含有活性化学物质和多糖基质颗粒的组合物，其通过引入N-乙烯基内酰胺单体和疏水共聚单体的共聚物，在水溶液中具有改善的水分散性和分散稳定性。 基质的改进性能促进其作为分散剂用于各种制剂中，其中需要土壤和皮肤的亲和力或活性化学品的持续释放，如在药物，芽前和芽后农药和化妆品制剂中。 本发明还涉及基于使用本发明的多糖/共聚物基质的制剂的制备和用途。