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公开(公告)号：US06608040B1
公开(公告)日：2003-08-19
申请号：US09297808
申请日：2001-09-27
IPC分类号： A01N4304
CPC分类号： A61L27/507 , A61F2310/00365 , A61F2310/00383 , A61L15/28 , A61L15/32 , A61L15/325 , A61L24/10 , A61L24/102 , A61L24/104 , A61L26/0023 , A61L26/0033 , A61L26/0038 , A61L27/20 , A61L27/22 , A61L27/222 , A61L27/24 , A61L27/3616 , A61L27/3645 , A61L27/3662 , A61L27/3687 , A61L2430/40 , C08L5/08
摘要： Biocompatible cross-linked materials, suitable for use in implants, wound dressings, and blood substitutes, are described. The materials are prepared by cross-linking biological substances, such as collagen, chitosan, or hemoglobin, with genipin, a naturally occurring cross-linking agent. The cross-linking agent has much lower toxicity than conventionally used reagents, and the cross-linked products have good thermal and mechanical stability as well as biocompatibility.
摘要翻译： 描述适用于植入物，伤口敷料和血液代用品的生物相容性交联材料。 这些材料是通过将天然存在的交联剂与天蚕素交联生物物质如胶原蛋白，壳聚糖或血红蛋白来制备的。 交联剂的毒性低于常规使用的试剂，交联产物具有良好的热和机械稳定性以及生物相容性。
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公开(公告)号：US08535640B1
公开(公告)日：2013-09-17
申请号：US13776111
申请日：2013-02-25
申请人： Hsing-Wen Sung , Ha Giang Thi Nguyen , Fang Yi Su , Li-Wen Hsu , Er-Yuan Chung , Hosheng Tu
发明人： Hsing-Wen Sung , Ha Giang Thi Nguyen , Fang Yi Su , Li-Wen Hsu , Er-Yuan Chung , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/722 , A61K9/0007 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K9/5161 , A61K38/00 , A61K47/6935 , A61K47/6939 , A61K49/0043 , A61K49/0093 , B82Y5/00
摘要： The invention discloses a composition of nanoparticles composed of positively charged chitosan, one negatively charged substrate, and optionally a zero-charge compound or at least one tumor necrosis factor inhibitor for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
摘要翻译： 本发明公开了一种由带正电荷的壳聚糖，一种带负电荷的底物和任选的零电荷化合物或至少一种用于口服递送的肿瘤坏死因子抑制剂组成的纳米颗粒组合物。 基于壳聚糖的纳米颗粒的特征在于具有正的表面电荷和增强的口服药物递送的渗透性。
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公开(公告)号：US08349799B1
公开(公告)日：2013-01-08
申请号：US13525307
申请日：2012-06-16
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Er-Yuan Chuang , Hosheng Tu
IPC分类号： A61K38/00
CPC分类号： A61K31/722 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K9/5161 , A61K38/00 , A61K47/6935 , A61K47/6939 , A61K49/0043 , A61K49/0093 , B82Y5/00
摘要： The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for drug delivery.
摘要翻译： 本发明公开了一种由壳聚糖，聚谷氨酸和用于口服递送的生物活性剂组成的生物活性纳米粒子的药物组合物。 基于壳聚糖的纳米颗粒的特征在于具有正的表面电荷并增加药物递送的渗透性。
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公开(公告)号：US08287905B1
公开(公告)日：2012-10-16
申请号：US13438764
申请日：2012-04-03
申请人： Hsing-Wen Sung , Er-Yuan Chuang , Ha Giang Thi Nguyen , Fang Yi Su , Kiran Sonaje , Hosheng Tu
发明人： Hsing-Wen Sung , Er-Yuan Chuang , Ha Giang Thi Nguyen , Fang Yi Su , Kiran Sonaje , Hosheng Tu
IPC分类号： A61K9/66
CPC分类号： A61K9/5161 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K38/00 , A61K47/6935 , A61K47/6939
摘要： The invention discloses a composition of chitosan-shelled nanoparticles and methods of manufacturing. The chitosan-shelled nanoparticles are characterized with a positive surface charge and enhanced epithelial permeability for oral drug delivery.
摘要翻译： 本发明公开了一种壳聚糖壳形纳米颗粒的组成及其制造方法。 壳聚糖壳的纳米粒子的特征在于具有正的表面电荷和增强的口服药物递送的上皮通透性。
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公开(公告)号：US08257740B1
公开(公告)日：2012-09-04
申请号：US13136912
申请日：2011-08-15
申请人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Ho-Ngoc Nguyen , Hosheng Tu
IPC分类号： A61K9/14
CPC分类号： A61K9/5161 , A61K9/0019 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K47/6935 , A61K47/6939
摘要： The invention discloses a composition of chitosan-shelled nanoparticles and methods of manufacturing. The chitosan-shelled nanoparticles are characterized with a positive surface charge and enhanced epithelial ermeability for oral drug delivery.
摘要翻译： 本发明公开了一种壳聚糖壳形纳米颗粒的组成及其制造方法。 壳聚糖壳的纳米颗粒的特征在于具有正的表面电荷和增强的口服药物递送的上皮可渗透性。
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公开(公告)号：US07993624B2
公开(公告)日：2011-08-09
申请号：US12931202
申请日：2011-01-26
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/0043 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55
摘要： The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge. The bioactive agent is hydrophobic or lipophilic in nature and is associated with micelles before being encapsulated in nanoparticles.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种以正表面电荷为特征的生物活性剂组成的纳米颗粒。 生物活性剂本质上是疏水性或亲脂性的，并且在包封在纳米颗粒中之前与胶束相关。
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公开(公告)号：US07988949B2
公开(公告)日：2011-08-02
申请号：US12931251
申请日：2011-01-27
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K9/4891 , A61K9/19 , A61K9/5146 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one antibiotics or equivalent bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
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公开(公告)号：US07919072B1
公开(公告)日：2011-04-05
申请号：US12462576
申请日：2009-08-05
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/19 , A61K9/2077 , A61K9/2081 , A61K9/2806 , A61K9/4891 , A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/445 , A61K31/55 , A61K47/26 , A61K47/34 , A61K47/36
摘要： The invention discloses the bioactive nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and enhanced permeability in oral drug delivery.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种生物活性剂组成的生物活性纳米颗粒，其特征在于具有阳性表面电荷并且在口服药物递送中具有增强的渗透性。
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公开(公告)号：US07897585B1
公开(公告)日：2011-03-01
申请号：US12378976
申请日：2009-02-20
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
IPC分类号： A01N43/04
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/19 , A61K9/4891 , A61K9/5146 , A61K9/5153 , A61K9/5161 , A61K9/5192 , A61K31/445 , A61K31/55 , A61K38/37 , A61K38/4846 , A61K47/26
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one anti-hemophilic factor or bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
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公开(公告)号：US07871990B1
公开(公告)日：2011-01-18
申请号：US12456927
申请日：2009-06-24
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/0043 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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