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    DPP4 INHIBITOR AND PHARMACEUTICAL USE THEREOF
    1.
    发明申请
    DPP4 INHIBITOR AND PHARMACEUTICAL USE THEREOF 审中-公开
    DPP4抑制剂及其药物用途

    公开(公告)号：US20080175837A1

    公开(公告)日：2008-07-24

    申请号：US11927051

    申请日：2007-10-29

    申请人： Chiori Ijichi ,  Naoyuki Yamada ,  Toshihiro Hatanaka ,  Kenji Takehana ,  Giovanni Miotto ,  Oriano Marin ,  Andrea Carpi ,  Denis Bertaggia

    发明人： Chiori Ijichi ,  Naoyuki Yamada ,  Toshihiro Hatanaka ,  Kenji Takehana ,  Giovanni Miotto ,  Oriano Marin ,  Andrea Carpi ,  Denis Bertaggia

    IPC分类号： A61K39/395 ,  A61K38/05 ,  A61P3/10 ,  A61P3/04 ,  C07C229/04 ,  G01N33/53 ,  A61P25/22 ,  C07K16/40

    CPC分类号： A61K31/195 ,  C07K16/2896 ,  C07K16/40

    摘要： The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.

    摘要翻译： 本发明提供一种Dpp4抑制剂，其包含下式（1）的亮氨酸衍生物或下式（2）的甲硫氨酸衍生物：其中R 1和R 3表示氢原子（H）和L-氨基酸残基 ; R2表示羟基（OH），碳原子数1〜6的烷氧基，氨基（NH2），碳原子数1〜6的烷基氨基，甘氨酸残基，β-丙氨酸残基，L-氨基酸（脯氨酸， 丙氨酸和苯丙氨酸）残基或L-氨基酸酰胺（脯氨酸酰胺，丙氨酸酰胺和苯丙氨酸酰胺除外）残基; R 4表示羟基（OH），碳原子数1〜6的烷氧基，氨基（NH 2），碳原子数1〜6的烷基氨基，甘氨酸残基，β-丙氨酸残基，L-氨基酸（脯氨酸 和丙氨酸）残基或L-氨基酸酰胺（除脯氨酰胺和丙氨酸酰胺除外）残基。 这些衍生物也作为自噬调节剂。

    FUEL INJECTION CONTROL DEVICE AND FUEL INJECTION CONTROL METHOD FOR INTERNAL COMBUSTION ENGINE
    4.
    发明申请
    FUEL INJECTION CONTROL DEVICE AND FUEL INJECTION CONTROL METHOD FOR INTERNAL COMBUSTION ENGINE 有权
    燃油喷射控制装置和内燃机燃油喷射控制方法

    公开(公告)号：US20150019110A1

    公开(公告)日：2015-01-15

    申请号：US14383240

    申请日：2013-03-05

    申请人： Ryo Suzuki ,  Takeshi Miyaura ,  Yoshiyasu Ito ,  Toyomori Tsuiki ,  Naoyuki Yamada

    发明人： Ryo Suzuki ,  Takeshi Miyaura ,  Yoshiyasu Ito ,  Toyomori Tsuiki ,  Naoyuki Yamada

    IPC分类号： F02D41/36

    CPC分类号： F02D41/36 ,  F02D41/2467 ,  F02D41/40 ,  F02D2200/0602 ,  Y02T10/44

    摘要： An electronic control unit detects a manner of fluctuation of a fuel pressure with injection of fuel by a fuel injection valve with the use of a fuel pressure sensor, and calculates a tendency of deviation of an actual fuel injection characteristic of the fuel injection valve with respect to a basic fuel injection characteristic on the basis of a result of comparison between a detected temporal waveform and a basic temporal waveform. The tendency of deviation is reflected at a predetermined reflection rate (R) at the time of updating a learned value (Gij) for compensating for an individual difference of the fuel injection valve. The predetermined reflection rate (R) is increased when an accumulated value (D) of a vehicle travel distance is shorter than a predetermined value (Dth) as compared with when the accumulated value (D) is longer than or equal to the predetermined value (Dth).

    摘要翻译： 电子控制单元通过使用燃料压力传感器由燃料喷射阀喷射燃料来检测燃料压力的波动的方式，并且计算燃料喷射阀的实际燃料喷射特性相对于 基于检测到的时间波形与基本时间波形之间的比较结果，获得基本的燃料喷射特性。 在更新用于补偿燃料喷射阀的个体差异的学习值（Gij）时，以预定的反射率（R）反映偏差的趋势。 与当累积值（D）大于或等于预定值（D）相比，当车辆行驶距离的累积值（D）小于预定值（Dth）时，预定反射率（R）增加 Dth）。

    Fuel injection detecting device
    5.
    发明授权
    Fuel injection detecting device 有权
    燃油喷射检测装置

    公开(公告)号：US08566005B2

    公开(公告)日：2013-10-22

    申请号：US12731431

    申请日：2010-03-25

    申请人： Naoyuki Yamada ,  Koji Ishizuka

    发明人： Naoyuki Yamada ,  Koji Ishizuka

    IPC分类号： F02D41/30 ,  F02M63/00

    CPC分类号： F02D41/401 ,  F02D2200/0602 ,  F02D2250/04 ,  F02M47/027 ,  F02M63/0225 ,  Y02T10/44

    摘要： An actual maximum fuel injection rate is computed based on a falling waveform and a rising waveform of the fuel pressure. The falling waveform represents the fuel pressure detected by a fuel sensor during a period in which the fuel pressure increases due to a fuel injection rate decrease. The rising waveform represents the fuel pressure detected by the fuel sensor during a period in which the fuel pressure decreases due to a fuel injection rate increase. The falling waveform and the rising waveform are modeled by modeling functions. A reference pressure is computed based on pressure during a specified time period before the falling waveform is generated. An intersection pressure is computed, at which the straight lines expressed by the modeling functions intersect to each other. The maximum fuel injection rate is computed based on a fuel pressure drop from the reference pressure to the intersection pressure.

    摘要翻译： 基于下降波形和燃料压力的上升波形来计算实际的最大燃料喷射率。 下降波形表示在燃料压力由于燃料喷射速率降低而增加的时段期间由燃料传感器检测到的燃料压力。 上升波形表示燃料传感器在由于燃料喷射率增加而燃料压力降低的时段期间检测到的燃料压力。 下降波形和上升波形由建模功能建模。 基于在产生下降波形之前的指定时间段内的压力来计算参考压力。 计算交叉压力，在该交点压力下，由建模功能表达的直线彼此相交。 基于从参考压力到交叉口压力的燃料压降来计算最大燃料喷射速率。

    Radiation detector module
    6.
    发明授权
    Radiation detector module 有权
    辐射检测器模块

    公开(公告)号：US08497482B2

    公开(公告)日：2013-07-30

    申请号：US12842456

    申请日：2010-07-23

    申请人： Juhyun Yu ,  Yoshinori Sunaga ,  Naoyuki Yamada ,  Shinichi Inoue ,  Isao Takahashi

    发明人： Juhyun Yu ,  Yoshinori Sunaga ,  Naoyuki Yamada ,  Shinichi Inoue ,  Isao Takahashi

    IPC分类号： G01T1/24

    CPC分类号： G01T7/00 ,  G01T1/242 ,  G01T1/243

    摘要： A radiation detector module includes a radiation detecting substrate including a plurality of semiconductor devices mounted thereon for detecting radiation, a fixing member for holding the radiation detecting substrate, and a circuit substrate connected to the radiation detecting substrate. The radiation detecting substrate further includes a mounting board including an edge portion connected to the circuit substrate at one end thereof, and a flexible substrate including a wiring pattern connected to the plurality of semiconductor devices. The fixing member includes a bottom, a first side wall extending in a normal direction to the bottom from one end of the bottom, a second side wall extending in the normal direction to the bottom from the other end of the bottom, and substrate supporting portions on the first side wall and the second side wall.

    摘要翻译： 辐射检测器模块包括：辐射检测基板，包括安装在其上的用于检测辐射的多个半导体器件，用于保持放射线检测基板的固定部件和连接到放射线检测基板的电路基板。 放射线检测基板还包括安装基板，其包括在其一端连接到电路基板的边缘部分，以及包括连接到多个半导体器件的布线图案的柔性基板。 固定构件包括底部，从底部的一端沿垂直方向延伸到底部的第一侧壁，从底部的另一端沿垂直方向延伸到底部的第二侧壁和基底支撑部分 在第一侧壁和第二侧壁上。

    Radiological imaging apparatus
    8.
    发明授权
    Radiological imaging apparatus 有权
    放射成像装置

    公开(公告)号：US07372035B2

    公开(公告)日：2008-05-13

    申请号：US11206738

    申请日：2005-08-19

    申请人： Kazuma Yokoi ,  Hiroshi Kitaguchi ,  Takafumi Ishitsu ,  Naoyuki Yamada ,  Kensuke Amemiya ,  Yuuichirou Ueno ,  Katsutoshi Tsuchiya ,  Norihito Yanagita

    发明人： Kazuma Yokoi ,  Hiroshi Kitaguchi ,  Takafumi Ishitsu ,  Naoyuki Yamada ,  Kensuke Amemiya ,  Yuuichirou Ueno ,  Katsutoshi Tsuchiya ,  Norihito Yanagita

    IPC分类号： G01T1/24

    CPC分类号： G01T1/241 ,  G01T1/249

    摘要： In a radiological imaging apparatus, a radiation detecting section includes semiconductor detectors arranged in four columns and four rows. Each of the semiconductor detectors includes a semiconductor base material, and an anode electrode film (first electrode film) and a cathode electrode film (second electrode film) lying opposite each other so as to sandwich the semiconductor base material between them. A first conductive member is installed on each first electrode film. Second electrode films of four semiconductor detectors within a row are connected together using one second conductive member. A shaping amplifier connected to the first conductive members with a wire executes a waveform shaping process using a shaping time shorter than that of a shaping amplifier connected to the second conductive member with a wire; the first conductive members are provided for the four semiconductor detectors within a column.

    摘要翻译： 在放射线成像装置中，放射线检测部包括以四列四列排列的半导体检测器。 每个半导体检测器包括半导体基底材料，以及彼此相对放置以将半导体基底材料夹在它们之间的阳极电极膜（第一电极膜）和阴极电极膜（第二电极膜）。 第一导电构件安装在每个第一电极膜上。 一行中的四个半导体检测器的第二电极膜使用一个第二导电构件连接在一起。 使用导线连接到第一导电部件的整形放大器使用比使用导线连接到第二导电部件的整形放大器的成形时间短的成形时间来执行波形整形处理; 为列中的四个半导体检测器提供第一导电构件。

    Method of analyzing protein
    9.
    发明申请
    Method of analyzing protein 审中-公开
    分析蛋白质的方法

    公开(公告)号：US20050147720A1

    公开(公告)日：2005-07-07

    申请号：US11039791

    申请日：2005-01-24

    申请人： Naoyuki Yamada ,  Shinichi Ozawa ,  Naoko Kageyama ,  Hiroshi Miyano

    发明人： Naoyuki Yamada ,  Shinichi Ozawa ,  Naoko Kageyama ,  Hiroshi Miyano

    IPC分类号： G01N33/02 ,  G01N33/533 ,  G01N33/58 ,  G01N33/68

    CPC分类号： G01N33/6827

    摘要： A sample is analyzed for trace amounts of protein by dot blotting and subsequent fluorescence staining. According to this method, trace amounts of proteins such as an allergen in a food, a drink, a food additive, a medicament and feed etc. can be simply analyzed with high sensitivity. By providing the objective analysis method as described above, quantitative analysis and limit analysis of a protein contained in a sample can be performed.

    摘要翻译： 通过斑点印迹和随后的荧光染色分析样品中痕量的蛋白质。 根据该方法，可以以高灵敏度简单地分析痕量的食品，饮料，食品添加剂，药物和饲料中的过敏原等蛋白质。 通过提供如上所述的客观分析方法，可以进行样品中包含的蛋白质的定量分析和极限分析。

    Nuclear reactor
    10.
    发明授权
    Nuclear reactor 失效
    核反应堆

    公开(公告)号：US06718001B2

    公开(公告)日：2004-04-06

    申请号：US09942945

    申请日：2001-08-31

    申请人： Masataka Hidaka ,  Tadashi Fujii ,  Masaya Ohtsuka ,  Naoyuki Yamada ,  Junichi Yamashita

    发明人： Masataka Hidaka ,  Tadashi Fujii ,  Masaya Ohtsuka ,  Naoyuki Yamada ,  Junichi Yamashita

    IPC分类号： G21C900

    CPC分类号： G21C15/18 ,  G21Y2002/301 ,  G21Y2002/50 ,  G21Y2004/30 ,  Y02E30/40

    摘要： In an indirect cycle nuclear reactor, a size of the reactor containment vessel is decreased by removing decay heat inside the reactor pressure vessel without using any active component to improve the economic feasibility. A main steam pipe communicating with a heat exchanger of the indirect cycle nuclear reactor is branched in a position upstream of a main steam isolation valve to connect the branched pipe to a heat exchanger in a pressure suppression pool through an isolation valve. A feed water pipe is also branched in a position upstream of an isolation valve to connect the branched pipe to the heat exchanger through the isolation valve. Decay heat is dissipated from the heat exchanger into the pressure suppression pool, and condensed water condensed by heat dissipation is returned to the heat exchanger to cool the inside of the pressure vessel. Heat in the pressure suppression pool is transferred from a condensing type heat exchanger to a heat dissipater outside a containment vessel to be dissipated to the outside of the containment vessel.

    摘要翻译： 在间接循环核反应堆中，通过在反应器压力容器内除去腐蚀热而不使用任何活性组分来改善反应堆容纳容器的尺寸以改善经济可行性。 与间接循环核反应堆的热交换器连通的主蒸汽管在主蒸汽隔离阀的上游位置分支，以通过隔离阀将分支管连接到压力抑制池中的热交换器。 给水管也在隔离阀的上游位置分支，以通过隔离阀将分支管连接到热交换器。 衰变热从热交换器消散到压力抑制池中，通过散热冷凝的冷凝水返回到热交换器以冷却压力容器的内部。 压力抑制池中的热量从冷凝式热交换器传送到安全壳外部的散热器，以散发到安全壳的外部。