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8 条记录 (耗时 0.021 秒)

    Recombinant human anti-Lewis Y antibodies
    3.
    发明授权
    Recombinant human anti-Lewis Y antibodies 失效
    重组人抗Lewis Y抗体

    公开(公告)号：US06518415B1

    公开(公告)日：2003-02-11

    申请号：US08859648

    申请日：1997-05-20

    申请人： Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

    发明人： Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

    IPC分类号： C07H2104

    CPC分类号： C07K16/34 ,  C07K16/30 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by the murine antibody Lewis Y. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumor types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumors. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.

    摘要翻译： 本发明提供对抗原Lewis Y特异性的几种人源化鼠抗体的产生，其被鼠抗体Lewis Y识别。Lewis Y抗原在正常组织中表达，但在某些肿瘤类型中表达水平较高，因此 抗原可用作乳腺癌，结肠癌，胃癌，食管癌，胰腺癌，十二指肠癌，肺癌，膀胱癌和肾癌和胃和胰岛细胞神经内分泌肿瘤的细胞标志物。 本发明还提供编码人源化Lewis Y特异性抗体的许多多核苷酸，用于产生人源化Lewis Y特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis Y特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供使用人源化Lewis Y特异性抗体治疗癌症的方法。

    Six high rolling mill
    5.
    发明授权
    Six high rolling mill 失效
    六高轧机

    公开(公告)号：US5622073A

    公开(公告)日：1997-04-22

    申请号：US321593

    申请日：1994-10-12

    申请人： Toshiki Hiruta ,  Kunio Kitamura ,  Ikuo Yarita

    发明人： Toshiki Hiruta ,  Kunio Kitamura ,  Ikuo Yarita

    IPC分类号： B21B13/02 ,  B21B13/14 ,  B21B27/10 ,  B21B27/02

    CPC分类号： B21B13/142 ,  B21B2013/028 ,  B21B2027/103 ,  B21B2267/18 ,  B21B2269/04 ,  B21B2269/06 ,  B21B2269/14 ,  B21B2269/16 ,  B21B27/10

    摘要： In a six high rolling mill comprising each pair of upper and lower work rolls, intermediate rolls and backup rolls, at least the intermediate rolls of the work and intermediate rolls being adapted for shifting in axial directions thereof, each of the intermediate rolls has a barrel length longer than that of the backup roll such that barrel ends of the intermediate roll extend beyond barrel ends of the-backup roll at maximum and minimum shifted positions of the intermediate roll, thereby providing a six high rolling mill having a high mill rigidity.

    摘要翻译： 在包括每对上下工作辊，中间辊和支承辊的六高轧机中，工件和中间辊的至少中间辊适于沿其轴向移动，每个中间辊具有筒体 长度大于支撑辊的长度，使得中间辊的筒端部在中间辊的最大和最小偏移位置处延伸超过支承辊的筒端，从而提供具有高轧机刚度的六高轧机。

    Recombinant human anti-Lewis Y antibodies
    6.
    发明授权
    Recombinant human anti-Lewis Y antibodies 失效
    重组人抗Lewis Y抗体

    公开(公告)号：US06310185B1

    公开(公告)日：2001-10-30

    申请号：US08207861

    申请日：1994-03-08

    申请人： Thomas P. Wallace ,  Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

    发明人： Thomas P. Wallace ,  Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

    IPC分类号： C07K1630

    CPC分类号： C07K16/34 ,  C07K16/30 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by murine atibodies specific for the Lewis Y antigen. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumour types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumours. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.

    摘要翻译： 本发明提供了对抗原Lewis Y特异性的几种人源化鼠抗体的产生，其被Lewis Y抗原特异性的鼠抗体识别。 Lewis Y抗原在正常组织中表达，但在某些肿瘤类型中表达水平较高，因此抗原可用作乳腺癌，结肠癌，胃癌，食管癌，胰腺癌，十二指肠癌，肺癌，膀胱癌， 肾癌和胃和胰岛细胞神经内分泌肿瘤。 本发明还提供编码人源化Lewis Y特异性抗体的许多多核苷酸，用于产生人源化Lewis Y特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis Y特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供使用人源化Lewis Y特异性抗体治疗癌症的方法。

    Isolated nucleic acid molecules which encode human anti-Lewis b antibodies
    7.
    发明授权
    Isolated nucleic acid molecules which encode human anti-Lewis b antibodies 失效
    编码人抗Lewis B抗体的分离的核酸分子

    公开(公告)号：US6025481A

    公开(公告)日：2000-02-15

    申请号：US80554

    申请日：1998-05-18

    申请人： T. Paul Wallace ,  William J. Harris ,  Frank J. Carr ,  Lloyd J. Old ,  Sydney Welt ,  Kunio Kitamura

    发明人： T. Paul Wallace ,  William J. Harris ,  Frank J. Carr ,  Lloyd J. Old ,  Sydney Welt ,  Kunio Kitamura

    IPC分类号： C07K16/30 ,  C07H21/02 ,  C12N1/20 ,  C12N5/00 ,  C12N15/00

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention provides for the production of several humanized murine antibodies specific for the Lewis b antigen, which is recognized by the murine antibody 58-1066. The antigen is expressed on cell lines from colon, lung, bladder, breast, renal, pancreatic and ovarian cancers. The expression of the antigen is greatly increased in cancer tissues as compared to its expression in the corresponding normal tissue. The invention also provides for numerous polynucleotide encoding humanized Lewis b antigen specific antibodies, expression vectors for producing humanized Lewis b antigen specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis b antigen specific antibodies. Additionally, the invention provides methods of treating cancer using Lewis b antigen specific antibodies.

    摘要翻译： 本发明提供了生产针对Lewis b抗原特异性的几种人源化鼠抗体，其被鼠抗体58-1066识别。 抗原在结肠癌，肺癌，膀胱癌，乳腺癌，肾癌，胰腺癌和卵巢癌的细胞系中表达。 与其相应的正常组织中的表达相比，癌组织中抗原的表达大大增加。 本发明还提供编码人源化Lewis B抗原特异性抗体的许多多核苷酸，用于产生人源化Lewis B抗原特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis B抗原特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供了使用Lewis b抗原特异性抗体治疗癌症的方法。

    Recombinant human anti-Lewis b antibodies
    8.
    发明授权
    Recombinant human anti-Lewis b antibodies 失效
    重组人抗Lewis B抗体

    公开(公告)号：US5795961A

    公开(公告)日：1998-08-18

    申请号：US388672

    申请日：1995-02-14

    申请人： T. Paul Wallace ,  William J. Harris ,  Frank J. Carr ,  Lloyd J. Old ,  Sydney Welt ,  Kunio Kitamura

    发明人： T. Paul Wallace ,  William J. Harris ,  Frank J. Carr ,  Lloyd J. Old ,  Sydney Welt ,  Kunio Kitamura

    IPC分类号： C07K16/30 ,  C07K14/00 ,  A61K38/16 ,  C12P21/08

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention provides for the production of several humanized murine antibodies specific for the Lewis b antigen, which is recognized by the murine antibody 58-1066. The antigen is expressed on cell lines from colon, lung, bladder, breast, renal, pancreatic and ovarian cancers. The expression of the antigen is greatly increased in cancer tissues as compared to its expression in the corresponding normal tissue. The invention also provides for numerous polynucleotide encoding humanized Lewis b antigen specific antibodies, expression vectors for producing humanized Lewis b antigen specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis b antigen specific antibodies. Additionally, the invention provides methods of treating cancer using Lewis b antigen specific antibodies.

    摘要翻译： 本发明提供了生产针对Lewis b抗原特异性的几种人源化鼠抗体，其被鼠抗体58-1066识别。 抗原在结肠癌，肺癌，膀胱癌，乳腺癌，肾癌，胰腺癌和卵巢癌的细胞系中表达。 与其相应的正常组织中的表达相比，癌组织中抗原的表达大大增加。 本发明还提供编码人源化Lewis B抗原特异性抗体的许多多核苷酸，用于产生人源化Lewis B抗原特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis B抗原特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供了使用Lewis b抗原特异性抗体治疗癌症的方法。