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公开(公告)号：US6143744A
公开(公告)日：2000-11-07
申请号：US369501
申请日：1999-08-05
申请人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号： A61K20060101 , C07C20060101 , C07C307/06 , C07D20060101 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , C07D491/048 , A61K31/16 , C07C259/06
CPC分类号： C07D211/36 , C07C307/06 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12
摘要： This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译： 本发明涉及作为金属蛋白酶抑制剂的式（I）的磺酰胺，含有它们的药物组合物，其使用方法和制备这些化合物的方法。
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公开(公告)号：US06376506B1
公开(公告)日：2002-04-23
申请号：US09469677
申请日：1999-12-22
申请人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号： A61K31435
CPC分类号： C07D295/26 , C07C307/06 , C07D211/36 , C07D213/74 , C07D401/04 , C07D401/12
摘要： This invention relates to sulfamides of formula (I) that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译： 本发明涉及作为金属蛋白酶抑制剂的式（I）的磺酰胺，含有它们的药物组合物，其使用方法和制备这些化合物的方法。
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公开(公告)号：US5998412A
公开(公告)日：1999-12-07
申请号：US9951
申请日：1998-01-21
申请人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号： A61K20060101 , C07C20060101 , C07C307/06 , C07D20060101 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , C07D491/048 , A61K31/435 , A61K31/495 , C07D495/04
CPC分类号： C07D211/36 , C07C307/06 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12
摘要： This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
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公开(公告)号：US6130220A
公开(公告)日：2000-10-10
申请号：US369677
申请日：1999-08-05
申请人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号： C07C307/06 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , A61K31/495 , A01N43/42 , C07D279/10 , C07D471/00 , C07D471/02
CPC分类号： C07D295/26 , C07C307/06 , C07D211/36 , C07D213/74 , C07D401/04 , C07D401/12
摘要： This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
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公开(公告)号：US5932595A
公开(公告)日：1999-08-03
申请号：US769049
申请日：1996-12-18
申请人： Steven Lee Bender , Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Lawrence Emerson Fisher , Robert Than Hendricks , Keshab Sarma
发明人： Steven Lee Bender , Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Lawrence Emerson Fisher , Robert Than Hendricks , Keshab Sarma
IPC分类号： C07D333/34 , A61K31/00 , A61K31/10 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/44 , A61K31/4402 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61P1/00 , A61P1/02 , A61P3/00 , A61P5/00 , A61P19/00 , A61P19/10 , A61P27/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C315/02 , C07C317/44 , C07C323/51 , C07D211/54 , C07D213/64 , C07D213/643 , C07D307/14 , C07D309/08 , C07D335/02 , C07D401/04 , C07D401/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , A01N43/40 , A01N37/10 , A01N43/36 , C07C233/00 , C07D207/00 , C07D211/08 , C07D333/32 , C07C415/00
CPC分类号： C07D213/643 , C07D211/54 , C07D309/08 , C07D401/06 , C07D407/12 , C07D409/12 , C07D413/12 , Y10S514/825 , Y10S514/885 , Y10S514/90 , Y10S514/903
摘要： The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.
摘要翻译： 本发明涉及式I化合物：基质金属蛋白酶抑制剂，含有它们的药物组合物，其使用方法和制备这些化合物的方法。
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公开(公告)号：US06787559B2
公开(公告)日：2004-09-07
申请号：US10267727
申请日：2002-10-09
申请人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
发明人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
IPC分类号： A61K31445
CPC分类号： C07D235/06 , C07C311/27 , C07D209/08 , C07D209/12 , C07D317/58
摘要： This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译： 本发明涉及某些作为前胶原C-蛋白酶抑制剂的磺酰胺衍生物，含有它们的药物组合物，其使用方法和制备这些化合物的方法。
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公开(公告)号：US06492394B1
公开(公告)日：2002-12-10
申请号：US09469660
申请日：1999-12-22
申请人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
发明人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
IPC分类号： A61K31445
CPC分类号： C07D235/06 , C07C311/27 , C07D209/08 , C07D209/12 , C07D317/58
摘要： A compound of the Formula (I): wherein Z, R1, R, and Ar2 are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.
摘要翻译： 式（I）的化合物：其中Z，R1，R和Ar2如说明书中所定义。 本发明还涉及作为原胶原C-蛋白酶抑制剂的式（I）的磺酰胺化合物，含有它们的药物组合物，其用途及其制备方法。
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公开(公告)号：US06844366B2
公开(公告)日：2005-01-18
申请号：US10267292
申请日：2002-10-09
申请人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
发明人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
IPC分类号： A61P43/00 , C07C311/27 , C07D209/08 , C07D209/12 , C07D235/06 , C07D317/58 , A61K31/165 , C07C259/04
CPC分类号： C07D235/06 , C07C311/27 , C07D209/08 , C07D209/12 , C07D317/58
摘要： This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译： 本发明涉及某些磺酰胺衍生物，其是前胶原C-蛋白酶的抑制剂，含有它们的药物组合物，其使用方法和制备这些化合物的方法。
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公开(公告)号：US20110070190A1
公开(公告)日：2011-03-24
申请号：US12890218
申请日：2010-09-24
IPC分类号： A61K31/4365 , C07D495/04 , A61K31/437 , A61K39/00 , A61K38/21 , A61K38/20 , A61K38/19 , A61P31/14 , C12N5/02
CPC分类号： C07D495/04
摘要： The invention discloses 1-N-substituted-6-(hetero)aryl-1H-thieno[3,2-d]pyrimidin-4-one derivatives of formula wherein R1, R2, R3 and R4 are as defined herein that inhibit Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译： 本发明公开了下式的1-N-取代-6-（杂）芳基-1H-噻吩并[3,2-d]嘧啶-4-酮衍生物其中R 1，R 2，R 3和R 4如本文所定义，其抑制丙型肝炎 病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号：US06872744B2
公开(公告)日：2005-03-29
申请号：US10255891
申请日：2002-09-26
IPC分类号： A61K31/404 , A61P15/06 , A61P19/02 , A61P19/06 , A61P25/28 , A61P29/00 , A61P43/00 , C07D209/10 , C07D209/30 , C07D209/36 , C07D209/42 , A61K31/40
CPC分类号： C07D209/42 , C07D209/10 , C07D209/30 , C07D209/36
摘要： This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
摘要翻译： 本发明涉及通常为抗炎和镇痛化合物的化合物，其由式I表示：其中A为-CH 2 - ， - O - ， - S - 或-S（O） - ; 而其它取代基如说明书中所定义; 或各异构体，异构体的混合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法。
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