公开(公告)号：US5817469A

公开(公告)日：1998-10-06

申请号：US535058

申请日：1995-10-30

申请人： Christa Hubner-Parajsz ,  Ulrich Essig ,  Fridl Lang ,  Rudolf Vogel

发明人： Christa Hubner-Parajsz ,  Ulrich Essig ,  Fridl Lang ,  Rudolf Vogel

IPC分类号： C07K16/40 ,  C12N5/10 ,  C12N5/18 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/573

CPC分类号： C07K16/40 ,  G01N33/573

摘要： The invention concerns monoclonal antibodies which bind to the CK-MB isoenzyme but not to the B or M subunit of CK-MB or to the CK-MM and CK-BB isoenzmyes, as well as a method for the diagnostic detection of CK-MB in a homogeneous diagnostic test using these antibodies.

摘要翻译： PCT No.PCT / EP94 / 01337 Sec。 371 1995年10月30日第 102（e）日期1995年10月30日PCT 1994年4月28日PCT PCT。 公开号WO94 / 25617 日期1994年11月10日本发明涉及与CK-MB同工酶但不结合CK-MB的B或M亚基或CK-MM和CK-BB同工酶的单克隆抗体，以及诊断方法 在使用这些抗体的同质诊断测试中检测CK-MB。

公开(公告)号：US5565364A

公开(公告)日：1996-10-15

申请号：US393946

申请日：1995-02-22

申请人： Rainer Schaefer ,  Bela Molnar ,  Christoph Berding ,  Peter Wolf ,  Fridl Lang

发明人： Rainer Schaefer ,  Bela Molnar ,  Christoph Berding ,  Peter Wolf ,  Fridl Lang

IPC分类号： G01N21/75 ,  G01N35/00 ,  G06F15/18 ,  G06G7/60 ,  G06N99/00 ,  G01N30/86 ,  G01N30/88

CPC分类号： G01N35/00693 ,  G01N21/75 ,  G01N2035/00702 ,  Y10T436/11

摘要： A method for the analysis of a component of a medical sample with the aid of an autoanalyzer, in which the sample is reacted with a reagent system and a physically measurable quantity X resulting from the reaction of the sample with the reagent system is measured in order to determine at least one measured value R for a specified sample and in which this at least one measured value R is further processed with the aid of a processing unit in a processing stage in order to determine an analytical result A. In the processing stage of the invention, use is made of the results of a neural net training, in which, for a number of standard samples for which the analytical result A is known, at least one measured value R, or a measurement result derived from several measured values R.sub.i, is applied to the input of a neural net.

摘要翻译： 借助自动分析仪分析医用样品的成分的方法，其中样品与试剂系统反应，并且由样品与试剂系统的反应产生的物理测量量X按顺序测量 确定用于指定样本的至少一个测量值R，并且其中在处理阶段中借助于处理单元进一步处理该至少一个测量值R.以便确定分析结果A.在处理阶段 本发明使用神经网络训练的结果，其中对于已知其分析结果A的多个标准样本，至少一个测量值R或从若干测量值R得到的测量结果 ，被应用于神经网络的输入。

公开(公告)号：US09423412B2

公开(公告)日：2016-08-23

申请号：US13988775

申请日：2011-11-28

申请人： Sayaka Sarwar ,  Shigeki Matsubara ,  Kenji Teshigawara ,  Emiko Suzuki ,  Osamu Matsumoto ,  Sylvia Rosenblatt ,  Peter Wolf ,  Fridl Lang ,  Roland Ihrig

发明人： Sayaka Sarwar ,  Shigeki Matsubara ,  Kenji Teshigawara ,  Osamu Matsumoto ,  Sylvia Rosenblatt ,  Peter Wolf ,  Fridl Lang ,  Roland Ihrig

IPC分类号： G01N35/10 ,  G01N35/00

CPC分类号： G01N35/1002 ,  G01N35/00663 ,  G01N2035/00673

摘要： Unlike conventional reagent storing means of an analyzing unit having a cold-storage function, replacement reagent storing means having no cold-storage function requires reagent management of a higher order. An automatic analyzer is provided that manages the placing elapsed time for a reagent vessel in replacement reagent storing means 2, compares the placing elapsed time for the reagent with a permissible placing limit value stored as one of analysis parameters for each analysis item, and determines as to whether or not the placing elapsed time exceeds permissible limit value. In this way, the analyzer prevents the degradation of the reagent and automatically transfers the reagent to an analyzing section for performing measurement.

摘要翻译： 与具有冷藏功能的分析单元的常规试剂储存装置不同，没有冷藏功能的替换试剂储存装置需要更高级的试剂管理。 提供了一种管理替代试剂储存装置2中的试剂容器的放置时间的自动分析装置，将试剂的放置经过时间与作为每个分析项目的分析参数之一存储的容许放置极限值进行比较，并且确定为 以及放置经过时间是否超过容许极限值。 以这种方式，分析器可以防止试剂的劣化，并自动将试剂转移到分析部分进行测量。

公开(公告)号：US09429586B2

公开(公告)日：2016-08-30

申请号：US13988767

申请日：2011-11-28

申请人： Atsushi Watanabe ,  Shigeki Matsubara ,  Kazuhiro Shimada ,  Kenji Teshigawara ,  Osamu Matsumoto ,  Sylvia Rosenblatt ,  Peter Wolf ,  Fridl Lang ,  Roland Ihrig

发明人： Atsushi Watanabe ,  Shigeki Matsubara ,  Kazuhiro Shimada ,  Kenji Teshigawara ,  Osamu Matsumoto ,  Sylvia Rosenblatt ,  Peter Wolf ,  Fridl Lang ,  Roland Ihrig

IPC分类号： G01N35/10 ,  G01N35/00 ,  G01N35/04

CPC分类号： G01N35/1002 ,  G01N35/00663 ,  G01N2035/00306 ,  G01N2035/00673 ,  G01N2035/0427

摘要： An automatic analyzer includes: first reagent storing means for storing a plurality of the reagent containers; second reagent storing means for storing a replacement reagent container in addition to the first reagent storing means; transfer means for transferring the reagent container from the second reagent storing means to the first reagent means; and a storing portion for storing the reagent container discharged from the second reagent storing means. The automatic analyzer includes control means for exercising control such that the information write means writes reagent information on the information recording medium immediately before the reagent container is transferred from the second reagent storing means to the first reagent storing means or immediately before the reagent container is discharged from the second reagent storing means to the storing portion.

摘要翻译： 一种自动分析仪包括：第一试剂储存装置，用于储存多个试剂容器; 第二试剂储存装置，除了所述第一试剂储存装置之外还存储替换试剂容器; 用于将试剂容器从第二试剂储存装置转移到第一试剂装置的转移装置; 以及存储部分，用于存储从第二试剂存储装置排出的试剂容器。 自动分析器包括用于进行控制的控制装置，使得信息写入装置在试剂容器从第二试剂储存装置转移到第一试剂储存装置之前或在试剂容器被排出之前立即将试剂信息写入信息记录介质上 从第二试剂储存装置到储存部分。

公开(公告)号：US5420042A

公开(公告)日：1995-05-30

申请号：US84008

申请日：1993-06-29

申请人： Rainer Schafer ,  Christoph Berding ,  Fridl Lang ,  Wilheim Kleider ,  Peter Wolf

发明人： Rainer Schafer ,  Christoph Berding ,  Fridl Lang ,  Wilheim Kleider ,  Peter Wolf

IPC分类号： G01N33/536 ,  G01N33/543 ,  G01N33/68 ,  G01N33/96 ,  G01N33/557

CPC分类号： G01N33/54313 ,  G01N33/68 ,  G01N33/96 ,  Y10S436/909 ,  Y10T436/11

摘要： Method for the analytical determination of the concentration of a component of a medical sample, in which a reaction of the sample with reagents leads to a time-dependent change S(t) in a measured quantity S and the concentration C correlates according to an evaluation curve C(X) with an input variable X derived from S(t), in which the calibration curve is ambiguous for at least a portion of the possible X values. In order to assign an input variable X to one of the sub-sections and thereby to obtain an unambiguous correlation to a particular concentration C, a training run and an analysis run are performed. In the training run, a discrimination algorithm is performed at least once, in which a discriminator set is generated from measurements of S(t), a score is generated in each case from the latter with a multivariate statistical technique and it is checked whether the scores can be divided into separate subsets, in which the concentrations are correctly assigned to the sub-sections of the calibration curve. The discrimination algorithm is repeated with different discriminator sets generated according to different generation methods from the measurements of S(t), in order to establish an operative discrimination algorithm. In the analysis run, an analysis score is calculated from measurements of S(t) according to the operative discrimination algorithm, the analysis score is compared with the boundary score and the measurement result is assigned to one of the sub-curves of the calibration curve by comparison of the analysis score with the boundary score.

摘要翻译： 用于分析测定样品与试剂反应导致测量量S和浓度C中的时间依赖性变化S（t）的药物样品成分浓度的分析方法根据评价 具有从S（t）导出的输入变量X的曲线C（X），其中校准曲线对于可能的X值的至少一部分是不明确的。 为了将输入变量X分配给一个子部分，从而获得与特定浓度C的明确相关性，执行训练运行和分析运行。 在训练运行中，至少执行一次鉴别算法，其中通过S（t）的测量产生鉴别器集合，在每种情况下，使用多变量统计技术从后者生成分数，并且检查是否 分数可以分为单独的子集，其中浓度被正确分配到校准曲线的子部分。 根据不同的生成方法从S（t）的测量中产生的不同鉴别器集重复鉴别算法，以便建立可操作的鉴别算法。 在分析运行中，根据手术识别算法从S（t）的测量中计算分析得分，将分析得分与边界得分进行比较，并将测量结果分配给校准曲线的一个子曲线 通过比较分析得分与边界得分。

公开(公告)号：US06210975B1

公开(公告)日：2001-04-03

申请号：US07771097

申请日：1991-10-04

申请人： Johann Karl ,  Fridl Lang

发明人： Johann Karl ,  Fridl Lang

IPC分类号： G01N33543

CPC分类号： G01N33/5306 ,  G01N33/53 ,  G01N33/54393 ,  G01N2015/0693 ,  Y10S436/824

摘要： The invention involves methods for determining analytes, and reagents for use in these methods. The methods and reagents use one or both of a polyvinyl/pyrolidone with a molecular weight of at least 360,000, and a polyethylene glycol with molecular weight of at least 40,000. The assays are carried out nephelometrically, or turbidometrically. The reagents include at least one antibody which binds the analyte. The hook effect is reduced or avoided in the practice of the invention.

摘要翻译： 本发明涉及用于测定分析物的方法和用于这些方法的试剂。 方法和试剂使用分子量至少为360,000的聚乙烯基吡咯烷酮和分子量至少为40,000的聚乙二醇中的一种或两种。 测定法以比浊法或浊度计进行。 试剂包括至少一种结合分析物的抗体。 在本发明的实践中，钩效应被减少或避免。