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1.发明申请ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST 有权工程化二氧化碳固定微生物生产基于碳的产品公开(公告)号：US20120122193A1
公开(公告)日：2012-05-17
申请号：US13349545
申请日：2012-01-12
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
IPC分类号： C12N1/13
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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2.发明申请Methods and Compositions for the Recombinant Biosynthesis of Terminal Olefins 审中-公开终端烯烃的重组生物合成的方法和组合物公开(公告)号：US20120107894A1
公开(公告)日：2012-05-03
申请号：US13284311
申请日：2011-10-28
CPC分类号： C12P5/026 , C07K2319/00 , C12N9/13 , C12N9/16 , C12P5/007 , C12Y208/02 , C12Y301/02
摘要： The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules.
摘要翻译： 本公开内容确定了用于修饰微生物细胞的方法和组合物，使得生物有效地合成末端烯烃，特别是使用这些生物来商业生产丙烯和相关分子。
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3.发明授权公开(公告)号：US08580542B2
公开(公告)日：2013-11-12
申请号：US13370654
申请日：2012-02-10
申请人： Christian P. Ridley
发明人： Christian P. Ridley
CPC分类号： C12N9/00 , C07K2319/00 , C12N9/1029 , C12N15/62 , C12P5/026
摘要： The NonA alkene synthase in Synechococcus sp. displays selective synthesis of 1-nonadecene. Heterologous recombination of a domain, i.e. the acyl binding domain, with other acyl binding proteins, affects acyl substrate chain-length binding selectivity and therefore the chain-length of the synthesized 1-alkenes. Compositions and methods are provided to selectively synthesize 1-alkenes of various chain lengths.
摘要翻译： 聚合球菌中的NonA烯烃合酶 显示1-十九烯的选择性合成。 结构域（即酰基结合结构域）与其他酰基结合蛋白的异源重组影响酰基底物链长度结合选择性，因此影响合成的1-烯烃的链长度。 提供组合物和方法以选择性合成各种链长的1-烯烃。
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4.发明申请Engineered CO2 Fixing Microorganisms Producing Carbon-Based Products of Interest 有权工程化的CO2固定微生物生产碳基产品公开(公告)号：US20110008861A1
公开(公告)日：2011-01-13
申请号：US12867738
申请日：2009-03-03
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些生物来商业生产乙醇，乙烯，化学品，聚合物，烷烃，类异戊二烯，药物产品或其中间体。
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公开(公告)号：US20120208253A1
公开(公告)日：2012-08-16
申请号：US13370654
申请日：2012-02-10
申请人： Christian P. Ridley
发明人： Christian P. Ridley
CPC分类号： C12N9/00 , C07K2319/00 , C12N9/1029 , C12N15/62 , C12P5/026
摘要： The NonA alkene synthase in Synechococcus sp. displays selective synthesis of 1-nonadecene. Heterologous recombination of a domain, i.e. the acyl binding domain, with other acyl binding proteins, affects acyl substrate chain-length binding selectivity and therefore the chain-length of the synthesized 1-alkenes. Compositions and methods are provided to selectively synthesize 1-alkenes of various chain lengths.
摘要翻译： 聚合球菌中的NonA烯烃合酶 显示1-十九烯的选择性合成。 结构域（即酰基结合结构域）与其他酰基结合蛋白的异源重组影响酰基底物链长度结合选择性，因此影响合成的1-烯烃的链长度。 提供组合物和方法以选择性合成各种链长的1-烯烃。
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6.发明授权Engineered CO2 fixing microorganisms producing carbon-based products of interest 有权工程化的二氧化碳固定微生物生产碳基产品公开(公告)号：US08227237B2
公开(公告)日：2012-07-24
申请号：US13174580
申请日：2011-06-30
申请人： Nikos B. Reppas , Martha Sholl , Sriram Kosuri , Brian D. Green , Christian P. Ridley , Frank A. Skraly , Dan E. Robertson , David A. Berry , Noubar B. Afeyan
发明人： Nikos B. Reppas , Martha Sholl , Sriram Kosuri , Brian D. Green , Christian P. Ridley , Frank A. Skraly , Dan E. Robertson , David A. Berry , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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7.发明授权Engineered CO2 fixing microorganisms producing carbon-based products of interest 有权工程化的二氧化碳固定微生物生产碳基产品公开(公告)号：US07981647B2
公开(公告)日：2011-07-19
申请号：US12867738
申请日：2009-03-03
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些生物来商业生产乙醇，乙烯，化学品，聚合物，烷烃，类异戊二烯，药物产品或其中间体。
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8.发明申请Methods and Compositions for the Extracellular Transport of Biosynthetic Hydrocarbons and Other Molecules 审中-公开生物合成碳氢化合物和其他分子的细胞外运输的方法和组成公开(公告)号：US20120135486A1
公开(公告)日：2012-05-31
申请号：US13232961
申请日：2011-09-14
CPC分类号： C07K14/195 , C07K14/245 , C07K2319/03 , C07K2319/033 , C12N9/0004 , C12N9/0006 , C12N15/74 , C12P5/02 , C12P5/026
摘要： The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into hydrocarbons, e.g., n-alkanes and n-alkenes, wherein the n-alkanes are secreted into the culture medium via recombinantly expressed transporter proteins. In particular, the use of such organisms for the commercial production of n-alkanes and related molecules is contemplated.
摘要翻译： 本公开确定用于将光自养生物修饰为宿主的方法和组合物，使得生物有效地将二氧化碳和光转化成烃，例如正烷烃和正烯烃，其中正烷烃通过重组方式分泌到培养基中 表达转运蛋白。 特别地，考虑使用这种生物来商业生产正烷烃和相关分子。
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9.发明申请ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST 有权工程化二氧化碳固定微生物生产基于碳的产品公开(公告)号：US20110262975A1
公开(公告)日：2011-10-27
申请号：US13174580
申请日：2011-06-30
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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