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1.发明申请Engineered CO2 Fixing Microorganisms Producing Carbon-Based Products of Interest 有权工程化的CO2固定微生物生产碳基产品公开(公告)号：US20110008861A1
公开(公告)日：2011-01-13
申请号：US12867738
申请日：2009-03-03
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些生物来商业生产乙醇，乙烯，化学品，聚合物，烷烃，类异戊二烯，药物产品或其中间体。
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2.发明申请ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST 有权工程化二氧化碳固定微生物生产基于碳的产品公开(公告)号：US20110262975A1
公开(公告)日：2011-10-27
申请号：US13174580
申请日：2011-06-30
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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3.发明申请ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST 有权工程化二氧化碳固定微生物生产基于碳的产品公开(公告)号：US20120122193A1
公开(公告)日：2012-05-17
申请号：US13349545
申请日：2012-01-12
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
IPC分类号： C12N1/13
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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4.发明授权Engineered CO2 fixing microorganisms producing carbon-based products of interest 有权工程化的二氧化碳固定微生物生产碳基产品公开(公告)号：US08227237B2
公开(公告)日：2012-07-24
申请号：US13174580
申请日：2011-06-30
申请人： Nikos B. Reppas , Martha Sholl , Sriram Kosuri , Brian D. Green , Christian P. Ridley , Frank A. Skraly , Dan E. Robertson , David A. Berry , Noubar B. Afeyan
发明人： Nikos B. Reppas , Martha Sholl , Sriram Kosuri , Brian D. Green , Christian P. Ridley , Frank A. Skraly , Dan E. Robertson , David A. Berry , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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5.发明授权Engineered CO2 fixing microorganisms producing carbon-based products of interest 有权工程化的二氧化碳固定微生物生产碳基产品公开(公告)号：US07981647B2
公开(公告)日：2011-07-19
申请号：US12867738
申请日：2009-03-03
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些生物来商业生产乙醇，乙烯，化学品，聚合物，烷烃，类异戊二烯，药物产品或其中间体。
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6.发明申请Methods and Compositions for the Recombinant Biosynthesis of Terminal Olefins 审中-公开终端烯烃的重组生物合成的方法和组合物公开(公告)号：US20120107894A1
公开(公告)日：2012-05-03
申请号：US13284311
申请日：2011-10-28
CPC分类号： C12P5/026 , C07K2319/00 , C12N9/13 , C12N9/16 , C12P5/007 , C12Y208/02 , C12Y301/02
摘要： The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules.
摘要翻译： 本公开内容确定了用于修饰微生物细胞的方法和组合物，使得生物有效地合成末端烯烃，特别是使用这些生物来商业生产丙烯和相关分子。
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公开(公告)号：US08741624B2
公开(公告)日：2014-06-03
申请号：US12539079
申请日：2009-08-11
申请人： Frank A. Skraly , Martha Sholl
发明人： Frank A. Skraly , Martha Sholl
摘要： Recombinant processes are provided whereby additional genes are introduced into E. coli which have been genetically engineered to produce PHA so that the improved strains produce PHA homopolymers and copolymers directly from diols. In preferred embodiments, PHAs containing 4-hydroxybutyrate monomers are produced directly from 1,4-butanediol; PHAs containing 5-hydroxyvalerate are produced from 1,5-pentanediol; PHAs containing 6-hydroxyhexanoate (6HH) are produced from 1,6-hexanediol; PHAs containing 3-hydroxypropionate are produced from 1,3-propanediol; PHAs containing 2-hydroxypropionate (lactate) are produced from 1,2-propanediol (propylene glycol); PHAs containing 2-hydroxyethanoate (glycolate) are produced from 1,2-ethanediol (ethylene glycol). Genes encoding these same enzyme activities can be introduced or their expression amplified in wild type PHA producers to improve the production of PHA homopolymers and copolymers directly from diol and other alcohol feedstocks. The PHA polymers are readily recovered and industrially useful as polymers or as starting materials for a range of chemical intermediates.
摘要翻译： 提供了重组方法，其中将另外的基因导入大肠杆菌，其已被遗传工程化以产生PHA，使得改良的菌株直接从二醇产生PHA均聚物和共聚物。 在优选的实施方案中，含有4-羟基丁酸酯单体的PHA直接由1,4-丁二醇制备; 含有5-羟基戊酸酯的PHA由1,5-戊二醇制备; 含有6-羟基己酸（6HH）的PHA由1,6-己二醇制成; 含有3-羟基丙酸的PHAs由1,3-丙二醇生产; 含有2-羟基丙酸酯（乳酸酯）的PHA由1,2-丙二醇（丙二醇）制成; 含有2-羟基乙醇酸（乙醇酸）的PHA由1,2-乙二醇（乙二醇）制备。 可以在野生型PHA生产者中引入编码这些相同酶活性的基因或其表达，以直接从二醇和其它醇原料改进PHA均聚物和共聚物的生产。 PHA聚合物易于回收并且在工业上可用作聚合物或作为一系列化学中间体的起始材料。
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公开(公告)号：US20100021919A1
公开(公告)日：2010-01-28
申请号：US12539079
申请日：2009-08-11
申请人： Frank A. Skraly , Martha Sholl
发明人： Frank A. Skraly , Martha Sholl
摘要： Recombinant processes are provided whereby additional genes are introduced into E. coli which have been genetically engineered to produce PHA so that the improved strains produce PHA homopolymers and copolymers directly from diols. In preferred embodiments, PHAs containing 4-hydroxybutyrate monomers are produced directly from 1,4-butanediol; PHAs containing 5-hydroxyvalerate are produced from 1,5-pentanediol; PHAs containing 6-hydroxyhexanoate (6HH) are produced from 1,6-hexanediol; PHAs containing 3-hydroxypropionate are produced from 1,3-propanediol; PHAs containing 2-hydroxypropionate (lactate) are produced from 1,2-propanediol (propylene glycol); PHAs containing 2-hydroxyethanoate (glycolate) are produced from 1,2-ethanediol (ethylene glycol). Genes encoding these same enzyme activities can be introduced or their expression amplified in wild type PHA producers to improve the production of PHA homopolymers and copolymers directly from diol and other alcohol feedstocks. The PHA polymers are readily recovered and industrially useful as polymers or as starting materials for a range of chemical intermediates.
摘要翻译： 提供了重组方法，其中将另外的基因导入大肠杆菌，其已被遗传工程化以产生PHA，使得改良的菌株直接从二醇产生PHA均聚物和共聚物。 在优选的实施方案中，含有4-羟基丁酸酯单体的PHA直接由1,4-丁二醇制备; 含有5-羟基戊酸酯的PHA由1,5-戊二醇制备; 含有6-羟基己酸（6HH）的PHA由1,6-己二醇制成; 含有3-羟基丙酸的PHAs由1,3-丙二醇生产; 含有2-羟基丙酸酯（乳酸酯）的PHA由1,2-丙二醇（丙二醇）制成; 含有2-羟基乙醇酸（乙醇酸）的PHA由1,2-乙二醇（乙二醇）制备。 可以在野生型PHA生产者中引入编码这些相同酶活性的基因或其表达，以直接从二醇和其它醇原料改进PHA均聚物和共聚物的生产。 PHA聚合物易于回收并且在工业上可用作聚合物或作为一系列化学中间体的起始材料。
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9.发明授权Methods and compositions for limiting viability of a modified host cell outside of designated process conditions 有权用于限制修饰的宿主细胞在指定工艺条件之外的存活力的方法和组合物公开(公告)号：US09005977B2
公开(公告)日：2015-04-14
申请号：US13238262
申请日：2011-09-21
IPC分类号： C12N9/00 , C12N1/20 , C12N15/00 , C12N15/74 , C07H21/04 , C12N15/63 , C07K14/435 , C12N13/00
CPC分类号： C12N15/63 , C07K14/435 , C12N13/00
摘要： The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
摘要翻译： 本发明提供了用于在指定的工艺条件之外抑制修饰的宿主细胞增殖的方法和组合物。 公开了当暴露于受控环境外的自然条件时提供具有降低的活力的宿主细胞的组合物和方法。
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10.发明申请Methods and Compositions for Limiting Viability of a Modified Host Cell Outside of Designated Process Conditions 有权用于限制指定过程条件之外的修饰宿主细胞活力的方法和组合物公开(公告)号：US20120077273A1
公开(公告)日：2012-03-29
申请号：US13238262
申请日：2011-09-21
CPC分类号： C12N15/63 , C07K14/435 , C12N13/00
摘要： The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
摘要翻译： 本发明提供了用于在指定的工艺条件之外抑制修饰的宿主细胞增殖的方法和组合物。 公开了当暴露于受控环境外的自然条件时提供具有降低的活力的宿主细胞的组合物和方法。
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