利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

144 条记录 (耗时 0.032 秒)

    Tetrahydronaphthalene compounds
    1.
    发明授权
    Tetrahydronaphthalene compounds 失效
    四氢萘化合物

    公开(公告)号：US5837807A

    公开(公告)日：1998-11-17

    申请号：US607734

    申请日：1996-02-27

    申请人： Christine Abrecht ,  Alfred Grieder ,  Klaus Muller ,  Daniel Obrecht

    发明人： Christine Abrecht ,  Alfred Grieder ,  Klaus Muller ,  Daniel Obrecht

    IPC分类号： A61K38/00 ,  C07K1/107 ,  C07K7/06 ,  C07K7/08 ,  C07K4/00 ,  C07D285/00 ,  C07K5/12

    CPC分类号： C07K7/08

    摘要： This invention is directed to tetrahydronaphthalene compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, bromine, cyano, formyl, hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, aryloxy, lower aralkoxy or aryl; R.sup.2 is an amino acid residue or a chain of 2 to 20 amino acid residues wherein reactive moieties in the side chains of the amino acid residue(s) is/are protected or unprotected, and wherein the amino group of the N-terminal amino acid is a free or protected amino group; A.sup.1, A.sup.2, A.sup.3 and A.sup.4 each are .alpha.-amino acid residues wherein A.sup.1 and A.sup.2 are in the L configuration and A.sup.3 and A.sup.4 are in the D configuration when the .alpha.-C atom of said .alpha.-amino acid residue is asymmetric; X is oxygen or sulphur; Y is a residue of the formula ##STR2## n is 0 or 1; R.sup.3 is hydrogen or lower alkyl; R.sup.4 is hydrogen or lower alkyl; and Z and the two C atoms together are an aromatic ring selected from the group of benzene, furan, thiophene, pyridine or pyrimidine, wherein said aromatic ring is substituted or unsubstituted; and salts thereof and their intermediates. The compounds are useful as mimetics of exposed helical domains of proteins in order to clarify their role with respect to interactions with other proteins or with DNA or RNA through .alpha.-helical conformation. They are therefore valuable aids in the determination of biologically active peptide sequences and are accordingly so-called "research tools". They are also potentially useful as medicaments.

    摘要翻译： 本发明涉及下式的四氢化萘化合物，其中R 1是氢，溴，氰基，甲酰基，羟基，低级烷基，低级烯基，低级炔基，低级烷氧基，芳氧基，低级芳烷氧基或芳基。 R2是氨基酸残基或2至20个氨基酸残基的链，其中氨基酸残基的侧链中的活性部分被保护或未被保护，并且其中N-末端氨基酸的氨基 是一个游离或保护的氨基; A1，A2，A3和A4各自为α-氨基酸残基，其中A1和A2为L构型，当所述α-氨基酸残基的α-C原子不对称时，A3和A4为D构型; X是氧或硫; （a）下式的残基：（a）（b）n为0或1; R3是氢或低级烷基; R4是氢或低级烷基; Z和两个C原子一起是选自苯，呋喃，噻吩，吡啶或嘧啶的芳环，其中所述芳环是取代或未取代的; 及其盐及其中间体。 这些化合物可用作蛋白质暴露的螺旋结构域的模拟物，以便澄清其在与其他蛋白质的相互作用或通过α-螺旋构象与DNA或RNA的作用。 因此，它们是测定生物活性肽序列的有价值的辅助因素，因此是所谓的“研究工具”。 它们也可能用作药物。

    Tetrahydronaphthalene derivatives
    2.
    发明授权
    Tetrahydronaphthalene derivatives 失效
    四氢萘衍生物

    公开(公告)号：US5644024A

    公开(公告)日：1997-07-01

    申请号：US292128

    申请日：1994-08-17

    申请人： Christine Abrecht ,  Klaus Muller ,  Daniel Obrecht ,  Arnold Trzeciak

    发明人： Christine Abrecht ,  Klaus Muller ,  Daniel Obrecht ,  Arnold Trzeciak

    IPC分类号： G01N33/68 ,  A61K38/00 ,  C07K5/062 ,  C07K7/06 ,  C07K7/08 ,  C07K7/54 ,  C07D285/00 ,  C07K4/00

    CPC分类号： C07K7/08 ,  Y02P20/55

    摘要： The present invention is concerned with tetrahydronaphthalene derivatives which are mimics of domains of peptides or proteins which can interact with other proteins or with DNA or RNA through .alpha.-helical conformation, said tetrahydronaphthalene derivatives having the formulae: ##STR1## are valuable aids in the determination of biologically active peptide sequences and are accordingly so-called "research tools". They are, however, also potentially suitable as medicaments.

    摘要翻译： 本发明涉及四氢萘衍生物，其是模拟可通过α-螺旋构象与其他蛋白质或与其它蛋白质或DNA或RNA相互作用的肽或蛋白质的结构域，所述四氢萘衍生物具有下列结构式： 有用的帮助确定生物活性肽序列，因此是所谓的“研究工具”。 然而，它们也可能适合作为药物。

    Arrangement for rreducing the Field Strength on an Electrode
    5.
    发明申请
    Arrangement for rreducing the Field Strength on an Electrode 有权
    降低电极场强的方案

    公开(公告)号：US20100012346A1

    公开(公告)日：2010-01-21

    申请号：US12518120

    申请日：2006-12-06

    申请人： Jens Hoppe ,  Dietmar Jahnel ,  Klaus Muller ,  Johann Schlager

    发明人： Jens Hoppe ,  Dietmar Jahnel ,  Klaus Muller ,  Johann Schlager

    IPC分类号： H01B7/00

    CPC分类号： H01F27/362

    摘要： An arrangement for reducing the electric field strength on the face of an electrode, wherein the face of the electrode is surrounded by at least one electric barrier, and a shielding electrode having a defined voltage potential is disposed in the vicinity of the face of the electrode. By using a retaining element that can be connected directly to the face of the electrode, the shielding wires can be quickly and easily positioned and fixed relative to the face of the electrode and the shielding electrode relative to the face.

    摘要翻译： 一种用于降低电极表面上的电场强度的装置，其中电极的表面被至少一个电屏障包围，并且具有限定电压电位的屏蔽电极设置在电极的表面附近 。 通过使用可以直接连接到电极的表面的保持元件，屏蔽线可以相对于电极和屏蔽电极相对于面的表面快速且容易地定位和固定。

    Method For Obtaining a Vegetable Plant Protein Fraction, in Particular For Producing Vegetable Ice Cream
    6.
    发明申请
    Method For Obtaining a Vegetable Plant Protein Fraction, in Particular For Producing Vegetable Ice Cream 有权
    获取蔬菜植物蛋白质分数的方法，特别是用于生产蔬菜冰淇淋的方法

    公开(公告)号：US20090011107A1

    公开(公告)日：2009-01-08

    申请号：US12087794

    申请日：2007-01-17

    申请人： Peter Eisner ,  Klaus Muller ,  Claudia Pickardt ,  Andreas Malberg

    发明人： Peter Eisner ,  Klaus Muller ,  Claudia Pickardt ,  Andreas Malberg

    IPC分类号： A23J1/00 ,  A23G9/38

    CPC分类号： A23G9/38 ,  A23G9/42 ,  A23J1/006 ,  A23J1/14 ,  A23J3/14 ,  A23L29/10 ,  A23V2002/00 ,  A23V2200/222

    摘要： A method for obtaining a vegetable protein fraction, in particular for producing vegetable ice cream, is described wherein vegetable parts are added to water or to an aqueous solvent in order to dissolve and/or disperse vegetable proteins from the vegetable parts, and wherein one or more vegetable protein fractions are separated from the aqueous mixture thus obtained by the separation. According to the method, one or more substances having lipophilic or amphiphilic boundary surfaces are added to the aqueous mixture in order to separate one or more vegetable protein fractions, to which dissolved and/or dispersed proteins having lipophilic or amphiphilic groups in the mixture attach. The substances including the attached proteins are separated from the mixture. A vegetable protein fraction having particularly good emulsifying characteristics is obtained by the method, the protein fraction being advantageous as an emulsifier in the production of vegetable ice cream.

    摘要翻译： 描述了一种用于获得植物蛋白级分，特别是用于生产植物性冰淇淋的方法，其中植物部分被添加到水或水性溶剂中，以便从植物部分溶解和/或分散植物蛋白质，并且其中一个或 从通过分离得到的含水混合物中分离更多的植物蛋白质级分。 根据该方法，将一种或多种具有亲脂性或两亲性边界表面的物质加入到含水混合物中，以分离出一种或多种植物蛋白质组分，混合物中溶解和/或分散的蛋白质具有亲油性或两亲性基团。 将包含附着蛋白质的物质与混合物分离。 通过该方法获得具有特别好的乳化特性的植物蛋白质级分，在制备蔬菜冰淇淋中蛋白质级分作为乳化剂是有利的。

    Self adjusting electric tappet switch
    8.
    发明授权
    Self adjusting electric tappet switch 失效
    自调电动挺杆开关

    公开(公告)号：US5947268A

    公开(公告)日：1999-09-07

    申请号：US961619

    申请日：1997-10-31

    申请人： Reinhard Lange ,  Klaus Muller ,  Ralf Elting ,  Wolfgang Huber

    发明人： Reinhard Lange ,  Klaus Muller ,  Ralf Elting ,  Wolfgang Huber

    IPC分类号： B60R16/02 ,  B60Q1/44 ,  B60R16/00 ,  H01H3/16 ,  H01H13/16 ,  H01H13/20 ,  H01H13/70

    CPC分类号： H01H3/166 ,  B60Q1/441 ,  B60R16/005 ,  H01H2003/167

    摘要： A self-adjusting electric tappet switch includes a slider linearly guided in a housing for activation or closure of one of several electrical contacts and a tappet which is selectively rotatable relative to the slider for adjustment of the travel limit of the switch. The slider has a first engagement portion provided with engagements parts, and the tappet includes a corresponding second engagement portion having an oblong cross-section provided with spaced apart circumferential grooves. The switch is self-adjusted by relative rotational movement between the slider and the tappet to lock the pair together. In an installation and adjustment position of the tappet and slider system, the slider is held in a predetermined fixed switching position in the housing to permit relative longitudinal slidable movement between the tappet and the slider for adjustment of the tappet without causing any movement of affecting the position of the slider within the housing. After the length of the tappet and slider is set, are locked together by relative rotation therebetween. Displacement of the tappet within the housing causes a corresponding movement of the slider thereby carried on the tappet within the housing relative to the electrical contacts.

    摘要翻译： 自调整电动挺杆开关包括在壳体中线性引导的滑块，用于激活或闭合多个电触点之一，以及可相对于滑块选择性地旋转的挺杆，用于调节开关的行程极限。 滑块具有设置有接合部分的第一接合部分，并且挺杆包括具有设置有间隔开的周向槽的长方形横截面的相应的第二接合部分。 开关通过滑块和挺杆之间的相对旋转运动进行自调节，以将该对锁定在一起。 在挺杆和滑块系统的安装和调节位置中，滑块被保持在壳体中预定的固定切换位置，以允许挺杆和滑块之间的相对纵向滑动运动，用于调节挺杆，而不会引起任何影响 滑动件在壳体内的位置。 在挺杆和滑块的长度设定之后，通过它们之间的相对旋转将其锁定在一起。 挺杆在壳体内的位移导致滑动件的相应移动，由此承载在壳体内的挺杆相对于电触头。