公开(公告)号：US08454550B2

公开(公告)日：2013-06-04

申请号：US13201593

申请日：2010-02-11

申请人： Christoph Koenig ,  Alexander Schroers ,  Andreas Wuepper ,  Alexander Heide ,  Juergen Klewinghaus

发明人： Christoph Koenig ,  Alexander Schroers ,  Andreas Wuepper ,  Alexander Heide ,  Juergen Klewinghaus

IPC分类号： A61M37/00

CPC分类号： A61M1/3653 ,  A61M1/3656 ,  A61M1/3659

摘要： An apparatus is disclosed for detecting moisture, which is intended for the use in an apparatus for monitoring an access to a patient for a device by means of which a fluid is conducted to and/or removed from a patient via a hose line, in particular for monitoring the vascular access during an extracorporeal blood treatment, wherein blood of a patient is removed from the patient via an arterial hose line, which has an arterial puncture cannula, and is conducted back to the patient via a venous hose line, which has a venous puncture cannula. The apparatus for detecting moisture is designed as a pad which is made of a flexible material and is to be applied onto the patient's skin and which comprises an upper side facing away from the patient's skin and a lower side facing the patient's skin. The pad comprises an opening for the passage of fluid, in particular blood, and a moisture sensor having contact elements for the connection of the same. The moisture sensor is capable of detecting blood flowing through the opening to the surface of the pad. The apparatus according to the invention is characterized in that the lower side of the pad is impervious to fluid.

摘要翻译： 公开了一种用于检测水分的装置，其用于在用于监测对患者进行装置的装置中的使用，通过该装置将流体经由软管线路向患者传导和/或从患者移除，特别是 用于在体外血液处理期间监测血管通路，其中患者的血液经由具有动脉穿刺插管的动脉软管管线从患者体内被移除，并且经由静脉软管管线传导回到患者体内，该静脉软管管线具有 静脉穿刺插管。 用于检测水分的装置被设计为由柔性材料制成并且被施加到患者皮肤上并且包括面向患者皮肤的上侧和面向患者皮肤的下侧的垫。 垫包括用于流体，特别是血液通过的开口，以及具有用于连接流体的接触元件的湿度传感器。 水分传感器能够检测流过穿过垫的表面的开口的血液。 根据本发明的装置的特征在于垫的下侧不渗透流体。

公开(公告)号：US20050015040A1

公开(公告)日：2005-01-20

申请号：US10856087

申请日：2004-05-28

申请人： Andreas Wuepper

发明人： Andreas Wuepper

IPC分类号： A61B5/00 ,  A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  A61N5/06 ,  A61M37/00

CPC分类号： A61M1/3679 ,  A61M1/16 ,  A61M1/3472 ,  A61M1/3479 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3627 ,  A61M1/3681 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/051 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/75 ,  A61N5/0621

摘要： The invention concerns a device for the extracorporeal irradiation of a patient's (P) bodily fluid containing bilirubin, comprising a first (10) and a second (12) line which can be connected to the patient (P), an impermeable irradiation unit for bodily fluids (14) connected therewith and located between the first (10) and the second (12) lines, and at least one adjustable feed unit for bodily fluids (16) located in the first (10) and/or the second (12) line, wherein by means of at least one feed unit for bodily fluids (16) an adjustable flow of bodily fluid through the lines (10, 12) and the irradiation unit for bodily fluids (14) is achievable, in which the first line (10) is designed to continually circulate the bodily fluid drawn from the patient (P) and route it to the irradiation unit for bodily fluids (14), and the second line (12) is designed to continually circulate the irradiated bodily fluid to the patient (P), and in which the irradiation unit for bodily fluids (14) contains an radiation source for the emission of electromagnetic radiation with a wavelength greater than 430 nm, preferably in a spectrum from 450 to 530 nm. The invention furthermore concerns a corresponding method.

摘要翻译： 本发明涉及一种用于体外照射患有（P）含有胆红素的体液的装置，其包括可连接到患者（P）的第一（10）和第二（12）管线，用于身体的不透液体照射单元 与第一（10）和第二（12）线之间连接的流体（14）和位于第一（10）和第二（12）线中的体液（14）和至少一个用于体液 其中通过用于体液（16）的至少一个进料单元可实现通过所述管线（10,12）和用于体液（14）的照射单元的可调节的流体流，其中所述第一管线 设计用于使从患者（P）抽出的体液连续循环并将其引导到用于体液（14）的照射单元，并且第二管线（12）被设计成使照射的体液连续循环到患者 （P），并且其中体液（14）的照射单元包含 是用于发射波长大于430nm的电磁辐射的辐射源，优选在450-530nm的光谱中。 本发明还涉及相应的方法。

公开(公告)号：US09629952B2

公开(公告)日：2017-04-25

申请号：US13588109

申请日：2012-08-17

申请人： John Heppe ,  Simone Lippert ,  Andreas Wuepper

发明人： John Heppe ,  Simone Lippert ,  Andreas Wuepper

IPC分类号： A61M1/36 ,  H01R4/28 ,  A61B5/053

CPC分类号： A61M1/3656 ,  A61B5/0531 ,  A61B5/0537 ,  A61M1/3653 ,  A61M1/3659 ,  A61M1/367 ,  A61M2205/13 ,  A61M2205/14 ,  H01R4/28 ,  Y10S439/909

摘要： A terminal clamp for a moisture sensor to be placed on a patient's skin in order to monitor a vascular access to a patient includes first, lower and second, upper legs for clamped fixing of terminal tab of moisture sensor, rear end pieces of the legs being connected. The terminal clamp includes terminal contacts for contacting electrical contact points of terminal tab, and a guide piece having a slot-shaped cutout for receiving terminal tab. Slot-shaped cutout of guide piece is bounded laterally by two stop elements so that terminal tab is held in terminal clamp in a predetermined position, in which terminal contacts of terminal clamp contact the electrical contact points of terminal tab. Upper leg comprises a latching device, which is fixed in slot-shaped cutout in a snap-in manner when terminal clamp is closed to lock upper leg in position on lower leg.

公开(公告)号：US20120298581A1

公开(公告)日：2012-11-29

申请号：US13478362

申请日：2012-05-23

申请人： Wolfgang Wehmeyer ,  Andreas Wuepper

发明人： Wolfgang Wehmeyer ,  Andreas Wuepper

IPC分类号： A61M1/16

CPC分类号： A61M1/16 ,  A61M1/1601 ,  A61M1/1613 ,  A61M1/1617 ,  A61M1/3656 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/52 ,  A61M2205/702 ,  A61M2205/707 ,  A61M2230/65

摘要： A device (25) and a method for detecting the cause of a deviation from an ideal operating state of an extracorporeal blood treatment, wherein blood to be treated in an extracorporeal blood circulation (9) flows through the blood chamber (3) of a dialyzer (1), subdivided by a semipermeable membrane (2) into a blood chamber (3) and a dialysis fluid chamber (4), and dialysis fluid flows through the dialysis fluid chamber (4). The method includes the following: changing a characteristic (170; 171) of the dialysis fluid upstream from the dialysis fluid chamber (1), measuring a characteristic of the dialysis fluid downstream from the dialysis fluid chamber, determining a dialysance or clearance at a certain point in time during the blood treatment, detecting a deviation in the dialysance or clearance, and detecting the cause of a deviation from an ideal operating state as a function of the certain point in time.

摘要翻译： 一种装置（25）和用于检测与体外血液处理的理想操作状态偏离的原因的方法，其中在体外血液循环（9）中待处理的血液流过透析器的血液室（3） （1），由半透膜（2）细分成血液室（3）和透析液室（4），透析液体流过透析液室（4）。 该方法包括以下步骤：改变透析液室（1）上游的透析液的特性（170; 171），测量透析液室下游的透析液的特性，确定一定的透析液或间隙 在血液处理期间的时间点，检测透析或间隙的偏差，以及作为特定时间点的函数来检测偏离理想操作状态的原因。

公开(公告)号：US09333285B2

公开(公告)日：2016-05-10

申请号：US11667661

申请日：2005-11-11

申请人： Andreas Wuepper

发明人： Andreas Wuepper

IPC分类号： A61M1/34

CPC分类号： A61M1/3413 ,  A61M1/3417 ,  A61M1/3437 ,  A61M1/3472 ,  A61M1/3479 ,  A61M1/3482 ,  A61M1/3486

摘要： A method for the depletion of at least one component of a fluid medium includes increasing the concentration of the at least one component to be depleted before its depletion. An apparatus for the depletion of the at least one component of the fluid medium has a concentration increasing unit for increasing the concentration of the component of the fluid medium to be depleted and a depletion unit disposed downstream thereof and in fluid communication therewith for the subsequent reduction in the concentration of the component to be depleted.

摘要翻译： 用于消耗流体介质的至少一种组分的方法包括在其耗尽之前增加待耗尽的至少一种组分的浓度。 用于耗尽流体介质的至少一个组分的装置具有浓度增加单元，用于增加要耗尽的流体介质的组分的浓度以及设置在其下游并与其流体连通的耗尽单元以用于随后的还原 在要耗尽的组分的浓度。

公开(公告)号：US07563240B2

公开(公告)日：2009-07-21

申请号：US10552716

申请日：2004-02-17

申请人： Malte Gross ,  Andreas Wuepper

发明人： Malte Gross ,  Andreas Wuepper

IPC分类号： A61M37/00

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52 ,  A61M2230/65 ,  B01D61/32

摘要： A blood purification device has a blood purification element divided into two chambers by a semipermeable membrane, with a first chamber as part of a dialysis fluid loop and a second chamber as part of an extracorporeal blood loop. By virtue of an analysis unit operatively connected to a sensor in the dialysis fluid loop, the device provides simple and uncomplicated determination of the blood purification performance of the blood purification element for a second material by derivation from a previously established blood purification performance for a first material. In this way, the device also determines the blood concentration of the second material during the blood treatment through measurements in the dialysis fluid without intervention in the treatment sequence.

摘要翻译： 血液净化装置具有通过半透膜分成两个室的血液净化装置，第一室作为透析液回路的一部分，第二室作为体外血液循环的一部分。 通过在透析流体回路中可操作地连接到传感器的分析单元，该装置通过从先前建立的第一种血液净化性能的推导，提供对第二种材料的血液净化元件的血液净化性能的简单和简单的确定 材料。 以这种方式，该装置还通过透析液中的测量而确定血液处理期间的第二材料的血液浓度，而不干预治疗顺序。

公开(公告)号：US20080011682A1

公开(公告)日：2008-01-17

申请号：US11667661

申请日：2005-11-11

申请人： Andreas Wuepper

发明人： Andreas Wuepper

IPC分类号： A61M1/34

CPC分类号： A61M1/3413 ,  A61M1/3417 ,  A61M1/3437 ,  A61M1/3472 ,  A61M1/3479 ,  A61M1/3482 ,  A61M1/3486

摘要： The invention relates to a method for the depletion of at least one component of a fluid medium, with the concentration of the at least one component to be depleted being increased before its depletion. The invention further relates to an apparatus for the depletion of at least one component of a fluid medium comprising a concentration increasing unit for increasing the concentration of the component of the fluid medium to be depleted and a depletion unit disposed downstream thereof and in fluid communication therewith for the subsequent reduction in the concentration of the component to be depleted.

摘要翻译： 本发明涉及一种用于消耗流体介质的至少一种组分的方法，其中要耗尽的至少一种组分的浓度在其耗尽之前增加。 本发明还涉及用于消耗流体介质的至少一种组分的装置，其包括用于增加要耗尽的流体介质的组分浓度的增浓单元和设置在其下游并与其流体连通的耗尽单元 用于随后降低要耗尽的组分的浓度。

公开(公告)号：US20060200064A1

公开(公告)日：2006-09-07

申请号：US10552716

申请日：2004-02-17

申请人： Malte Gross ,  Andreas Wuepper

发明人： Malte Gross ,  Andreas Wuepper

IPC分类号： A61M37/00 ,  B01D61/00 ,  C02F1/00 ,  B01D11/00 ,  C02F1/44

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52 ,  A61M2230/65 ,  B01D61/32

摘要： The present invention relates to the field of blood purification devices having a blood purification element (1), divided into two chambers by a semipermeable membrane (2), whose first chamber (3) is part of a dialysis fluid loop and whose second chamber (4) is part of an extracorporeal blood loop. The present invention allows simple and uncomplicated determination of the blood purification performance of the blood purification element for a second material, which is derived from a previously established blood purification performance for a first material, which deviates therefrom. In this way, the blood treatment device according to the present invention also allows the determination of the blood concentration of the second material during the blood treatment through measurements in the dialysis fluid without intervention in the treatment sequence, which was not possible with previous methods.

摘要翻译： 本发明涉及具有血液净化元件（1）的血液净化装置领域，其通过半透膜（2）分成两个腔室，其第一腔室（3）是透析液回路的一部分，并且其第二腔室 4）是体外血液循环的一部分。 本发明允许简单且简单地确定用于第二种材料的血液净化元件的血液净化性能，该第二种材料是从先前已建立的偏离其的第一种材料的血液净化性能得出的。 以这种方式，根据本发明的血液处理装置还允许通过透析液中的测量来确定血液处理期间的第二材料的血液浓度，而不干预治疗顺序，这对于先前的方法是不可能的。

公开(公告)号：US07846121B2

公开(公告)日：2010-12-07

申请号：US10856087

申请日：2004-05-28

申请人： Andreas Wuepper

发明人： Andreas Wuepper

IPC分类号： A61M37/00 ,  A61N1/30 ,  A61M31/00 ,  A61M1/00 ,  A61B5/00

CPC分类号： A61M1/3679 ,  A61M1/16 ,  A61M1/3472 ,  A61M1/3479 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3627 ,  A61M1/3681 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/051 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/75 ,  A61N5/0621

摘要： The invention concerns a device for the extracorporeal irradiation of a patient's (P) bodily fluid containing bilirubin, comprising a first (10) and a second (12) line which can be connected to the patient (P), an impermeable irradiation unit for bodily fluids (14) connected therewith and located between the first (10) and the second (12) lines, and at least one adjustable feed unit for bodily fluids (16) located in the first (10) and/or the second (12) line, wherein by means of at least one feed unit for bodily fluids (16) an adjustable flow of bodily fluid through the lines (10, 12) and the irradiation unit for bodily fluids (14) is achievable, in which the first line (10) is designed to continually circulate the bodily fluid drawn from the patient (P) and route it to the irradiation unit for bodily fluids (14), and the second line (12) is designed to continually circulate the irradiated bodily fluid to the patient (P), and in which the irradiation unit for bodily fluids (14) contains an radiation source for the emission of electromagnetic radiation with a wavelength greater than 430 nm, preferably in a spectrum from 450 to 530 nm. The invention furthermore concerns a corresponding method.

摘要翻译： 本发明涉及一种用于体外照射患有（P）含有胆红素的体液的装置，其包括可连接到患者（P）的第一（10）和第二（12）管线，用于身体的不透液体照射单元 与第一（10）和第二（12）线之间连接的流体（14）和位于第一（10）和第二（12）线中的体液（14）和至少一个用于体液 其中通过用于体液（16）的至少一个进料单元可实现通过所述管线（10,12）和用于体液（14）的照射单元的可调节的流体流，其中所述第一管线 设计用于使从患者（P）抽出的体液连续循环并将其引导到用于体液（14）的照射单元，并且第二管线（12）被设计成使照射的体液连续循环到患者 （P），并且其中体液（14）的照射单元包含 是用于发射波长大于430nm的电磁辐射的辐射源，优选在450-530nm的光谱中。 本发明还涉及相应的方法。