公开(公告)号：US20070108128A1

公开(公告)日：2007-05-17

申请号：US10580869

申请日：2004-09-11

申请人： Pascal Kopperschmidt ,  Malte Gross

发明人： Pascal Kopperschmidt ,  Malte Gross

IPC分类号： B01D61/32

CPC分类号： A61M1/3441 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3609 ,  A61M1/3639 ,  A61M2230/207

摘要： A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.

摘要翻译： 一种方法和装置，其使用体外血液透析装置来识别血液体外处理期间体外血液回路中的血流的损伤，其中振荡压力信号的至少一次谐波振荡在体外传播的相位角 确定血液回路。 基于对压力信号的至少一次谐波振荡的相位角的特征修改，在体外血液回路中检测出血流的损伤。 可以将相位角的时间修改与预定义的阈值进行比较，并且如果相位角的修改值大于预定阈值，则检测损伤。 该方法和装置允许早期鉴定血液透析装置中血液的凝结，从而可以及时启动对策。

公开(公告)号：US08784353B2

公开(公告)日：2014-07-22

申请号：US13123290

申请日：2009-10-02

申请人： Andreas Maierhofer ,  Malte Gross

发明人： Andreas Maierhofer ,  Malte Gross

IPC分类号： A61M37/00 ,  A61M39/00 ,  A61M39/10 ,  A61M39/22 ,  A61M1/36

CPC分类号： A61M1/367 ,  A61M1/3656 ,  A61M1/3663 ,  A61M39/10 ,  A61M39/105 ,  A61M39/1055 ,  A61M39/22 ,  A61M39/223 ,  A61M2039/1044 ,  A61M2039/229 ,  A61M2205/3515 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/6018 ,  A61M2205/6054 ,  F16K11/074

摘要： A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.

摘要翻译： 具有体外血液回路的体外血液处理装置的血流的逆转装置，包括从病人通向血液处理单元的动脉血线和从血液处理单元导入患者的静脉血液管路。 此外，体外血液处理装置包括用于逆转血流的装置，并且包括确定在体外血液处理期间血液流动的逆转的方法。 用于反转体外血液处理装置的血流的装置包括相对于彼此旋转以逆转血流的两个阀体。 用于反转血流的装置包括用于从体外血液处理装置的读取单元接收电磁高频场的通信装置，并且用于产生表征可被读取的阀体读取的阀体的位置的至少一个标识符 设备。

公开(公告)号：US20110196279A1

公开(公告)日：2011-08-11

申请号：US13123290

申请日：2009-10-02

申请人： Andreas Maierhofer ,  Malte Gross

发明人： Andreas Maierhofer ,  Malte Gross

IPC分类号： A61M1/14

CPC分类号： A61M1/367 ,  A61M1/3656 ,  A61M1/3663 ,  A61M39/10 ,  A61M39/105 ,  A61M39/1055 ,  A61M39/22 ,  A61M39/223 ,  A61M2039/1044 ,  A61M2039/229 ,  A61M2205/3515 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/6018 ,  A61M2205/6054 ,  F16K11/074

摘要： A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.

摘要翻译： 具有体外血液回路的体外血液处理装置的血流的逆转装置，包括从病人通向血液处理单元的动脉血线和从血液处理单元导入患者的静脉血液管路。 此外，体外血液处理装置包括用于逆转血流的装置，并且包括确定在体外血液处理期间血液流动的逆转的方法。 用于反转体外血液处理装置的血流的装置包括相对于彼此旋转以逆转血流的两个阀体。 用于反转血流的装置包括用于从体外血液处理装置的读取单元接收电磁高频场的通信装置，并且用于产生表征可被读取的阀体读取的阀体的位置的至少一个标识符 设备。

公开(公告)号：US20110046534A1

公开(公告)日：2011-02-24

申请号：US12920636

申请日：2009-03-03

申请人： Malte Gross

发明人： Malte Gross

IPC分类号： A61M1/00 ,  A61B5/05

CPC分类号： A61M1/367 ,  A61M5/158 ,  A61M2005/1588 ,  A61M2205/15

摘要： The invention relates to the monitoring of an access to a patient at a puncture point, in particular the monitoring of the arterial and/or venous vascular access during an extracorporeal blood treatment. The device according to the invention is a magnetoelastic moisture sensor, which is embedded in an absorbent material and is laid on the puncture point. For the case in which infusion solution and/or blood exits from the puncture point, the incorrect seating of the puncture cannula can be recognized reliably using the device according to the invention. The absorbent material having the embedded magnetoelastic moisture sensor can be laid like conventional bandage material or a gauze bandage on the puncture point.

摘要翻译： 本发明涉及在穿刺点处对病人的进入的监测，特别是在体外血液处理期间监测动脉和/或静脉血管通路。 根据本发明的装置是一种磁弹性水分传感器，其被嵌入吸收材料中并铺设在穿刺点上。 对于输液和/或血液从穿刺点离开的情况，可以使用根据本发明的装置可靠地识别穿刺套管的错位。 具有嵌入式磁弹性湿度传感器的吸收材料可以像传统的绷带材料或纱布绷带放置在穿刺点上。

公开(公告)号：US06939471B2

公开(公告)日：2005-09-06

申请号：US10393361

申请日：2003-03-21

申请人： Malte Gross ,  Andreas Maierhofer

发明人： Malte Gross ,  Andreas Maierhofer

IPC分类号： A61M1/16 ,  B01D61/32 ,  A61M1/14 ,  B01D61/24 ,  B01D61/28

CPC分类号： A61M1/16 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/1654 ,  A61M1/1656 ,  A61M1/361 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52

摘要： A method for determining a treatment parameter on a haemofiltration device, as well as a haemofiltration device for applying the method, based on the recognition that a determination method known from haemodialysis can, with little modification, be transferred to haemofiltration. To this effect a physical-chemical characteristic of the substitution fluid and of the fluid which is removed from the haemofilter by way of an ultrafiltrate outlet pipe, is determined. Furthermore, this characteristic is acquired before, after or during a change of this characteristic in the substitution fluid, and is evaluated. As a result, the ion dialysance and thus the urea clearance of a haemofiltration device, which can also be operated as a haemodiafiltration device, can be determined.

摘要翻译： 基于认识到从血液透析已知的测定方法可以很少改进的方法转移到血液过滤中，用于确定血液净化装置上的治疗参数以及用于应用该方法的血液净化装置的方法。 为此，确定了取代流体和通过超滤出口管从除污机除去的流体的物理化学特性。 此外，在替代液中的该特性的变化之前，之后或期间获取该特性，并进行评价。 结果，可以确定也可以作为血液透析过滤装置操作的血液净化装置的离子透析性以及因此的尿素清除率。

公开(公告)号：US08764987B2

公开(公告)日：2014-07-01

申请号：US13262407

申请日：2010-03-31

申请人： Malte Gross ,  Andreas Maierhofer

发明人： Malte Gross ,  Andreas Maierhofer

IPC分类号： B01D61/32 ,  B01D61/24 ,  B01D61/26 ,  B01D61/28 ,  A61M1/14

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/3609 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65

摘要： An apparatus and a method for the determination and regulation of the concentration of at least one dissolved substance in a fluid circuit, in which the fluid circuit includes at least two partial circuits separated by a filter in a semi-permeable manner, includes a detection unit for determining a concentration difference of at least one first dissolved substance, a determination unit for determining the influence of at least one second dissolved substance which is not identical to the at least one first dissolved substance, and a regulation unit for regulating the concentration of the at least one dissolved substance in the fluid circuit.

摘要翻译： 一种用于确定和调节流体回路中至少一种溶解物质的浓度的装置和方法，其中，所述流体回路包括以半渗透方式由过滤器隔开的至少两个部分回路，包括检测单元 用于确定至少一种第一溶解物质的浓度差的确定单元，用于确定与所述至少一种第一溶解物质不同的至少一种第二溶解物质的影​​响的判定单元，以及用于调节所述至少一种溶解物质浓度的调节单元 至少一种溶解物质在流体回路中。

公开(公告)号：US20140098359A1

公开(公告)日：2014-04-10

申请号：US14111248

申请日：2012-04-10

申请人： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Malerhofer ,  Alfred Gagel

发明人： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Malerhofer ,  Alfred Gagel

IPC分类号： A61B5/00 ,  G01N21/65 ,  G01N21/64

CPC分类号： A61B5/0082 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/367 ,  G01N21/6486 ,  G01N21/65

摘要： The present invention pertains to a method for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, the method comprising the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.

摘要翻译： 本发明涉及一种用于监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，所述方法包括以下步骤：将用于治疗的透析液样品至少照射至少 第一照射波长，检测由至少第一检测波长的被照射样品发射的光，检测波长与第一照射波长不同，并且基于该基准确定样品中至少一种分析物的存在和/或浓度 的检测光。

公开(公告)号：US08460552B2

公开(公告)日：2013-06-11

申请号：US10580869

申请日：2004-09-11

申请人： Pascal Kopperschmidt ,  Malte Gross

发明人： Pascal Kopperschmidt ,  Malte Gross

IPC分类号： B01D11/00 ,  B01D35/00

CPC分类号： A61M1/3441 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3609 ,  A61M1/3639 ,  A61M2230/207

摘要： A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.

摘要翻译： 一种方法和装置，其使用体外血液透析装置来识别血液体外处理期间体外血液回路中的血流的损伤，其中振荡压力信号的至少一次谐波振荡在体外传播的相位角 确定血液回路。 基于对压力信号的至少一次谐波振荡的相位角的特征修改，在体外血液回路中检测出血流的损伤。 可以将相位角的时间修改与预定义的阈值进行比较，并且如果相位角的修改值大于预定阈值，则检测损伤。 该方法和装置允许早期鉴定血液透析装置中血液的凝结，从而可以及时启动对策。

公开(公告)号：US07563240B2

公开(公告)日：2009-07-21

申请号：US10552716

申请日：2004-02-17

申请人： Malte Gross ,  Andreas Wuepper

发明人： Malte Gross ,  Andreas Wuepper

IPC分类号： A61M37/00

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52 ,  A61M2230/65 ,  B01D61/32

摘要： A blood purification device has a blood purification element divided into two chambers by a semipermeable membrane, with a first chamber as part of a dialysis fluid loop and a second chamber as part of an extracorporeal blood loop. By virtue of an analysis unit operatively connected to a sensor in the dialysis fluid loop, the device provides simple and uncomplicated determination of the blood purification performance of the blood purification element for a second material by derivation from a previously established blood purification performance for a first material. In this way, the device also determines the blood concentration of the second material during the blood treatment through measurements in the dialysis fluid without intervention in the treatment sequence.

摘要翻译： 血液净化装置具有通过半透膜分成两个室的血液净化装置，第一室作为透析液回路的一部分，第二室作为体外血液循环的一部分。 通过在透析流体回路中可操作地连接到传感器的分析单元，该装置通过从先前建立的第一种血液净化性能的推导，提供对第二种材料的血液净化元件的血液净化性能的简单和简单的确定 材料。 以这种方式，该装置还通过透析液中的测量而确定血液处理期间的第二材料的血液浓度，而不干预治疗顺序。

公开(公告)号：US20060200064A1

公开(公告)日：2006-09-07

申请号：US10552716

申请日：2004-02-17

申请人： Malte Gross ,  Andreas Wuepper

发明人： Malte Gross ,  Andreas Wuepper

IPC分类号： A61M37/00 ,  B01D61/00 ,  C02F1/00 ,  B01D11/00 ,  C02F1/44

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52 ,  A61M2230/65 ,  B01D61/32

摘要： The present invention relates to the field of blood purification devices having a blood purification element (1), divided into two chambers by a semipermeable membrane (2), whose first chamber (3) is part of a dialysis fluid loop and whose second chamber (4) is part of an extracorporeal blood loop. The present invention allows simple and uncomplicated determination of the blood purification performance of the blood purification element for a second material, which is derived from a previously established blood purification performance for a first material, which deviates therefrom. In this way, the blood treatment device according to the present invention also allows the determination of the blood concentration of the second material during the blood treatment through measurements in the dialysis fluid without intervention in the treatment sequence, which was not possible with previous methods.

摘要翻译： 本发明涉及具有血液净化元件（1）的血液净化装置领域，其通过半透膜（2）分成两个腔室，其第一腔室（3）是透析液回路的一部分，并且其第二腔室 4）是体外血液循环的一部分。 本发明允许简单且简单地确定用于第二种材料的血液净化元件的血液净化性能，该第二种材料是从先前已建立的偏离其的第一种材料的血液净化性能得出的。 以这种方式，根据本发明的血液处理装置还允许通过透析液中的测量来确定血液处理期间的第二材料的血液浓度，而不干预治疗顺序，这对于先前的方法是不可能的。