公开(公告)号：US20080090806A1

公开(公告)日：2008-04-17

申请号：US11665943

申请日：2005-10-18

申请人： Daniel Paone ,  Diem Nguyen ,  Christopher Burgey ,  James Deng

发明人： Daniel Paone ,  Diem Nguyen ,  Christopher Burgey ,  James Deng

IPC分类号： A61K31/55 ,  A61P25/00 ,  C07D471/04 ,  C07D471/20

CPC分类号： C07D471/04

摘要： The present invention is directed to compounds of Formula (I) and Formula (II) (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式（I）和式（II）的化合物（其中变量R1，R2，R3，R4，A，B，G，J，Q，T，U，V，W，X和Y为 如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20060194783A1

公开(公告)日：2006-08-31

申请号：US10551830

申请日：2004-04-09

申请人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

发明人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

IPC分类号： A61K31/554 ,  A61K31/55 ,  A61K31/553 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14

CPC分类号： C07D401/14 ,  C07D413/14

摘要： The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及用作CGRP拮抗剂的式I和式II化合物（其中变量R1，R2，R3，R4，R6，A，B，G，J，W，X和Y如本文所定义） 受体，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20050256098A1

公开(公告)日：2005-11-17

申请号：US11152537

申请日：2005-06-14

申请人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

发明人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

IPC分类号： A61K31/4188 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  A61P25/06 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/00 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：US20140100231A1

公开(公告)日：2014-04-10

申请号：US14047515

申请日：2013-10-07

申请人： Kenneth L. Arrington ,  Christopher Burgey ,  Robert Gilfillan ,  Yongxin Han ,  Mehul Patel ,  Chun Sing Li ,  Yaozong Li ,  Yunfu Luo ,  Zhiyu Lei

发明人： Kenneth L. Arrington ,  Christopher Burgey ,  Robert Gilfillan ,  Yongxin Han ,  Mehul Patel ,  Chun Sing Li ,  Yaozong Li ,  Yunfu Luo ,  Zhiyu Lei

IPC分类号： A61K31/513 ,  C07D405/14 ,  C07D403/06 ,  C07D471/04 ,  A61K45/06

CPC分类号： C07D471/04 ,  A61K31/513 ,  A61K45/06 ,  C07D239/52 ,  C07D239/54 ,  C07D239/56 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14

摘要： Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R1, R2, RE, L, M and Z are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

摘要翻译： 式I化合物是HIV逆转录酶抑制剂，其中R1，R2，RE，L，M和Z在本文中定义。 式I化合物及其药学上可接受的盐可用于抑制HIV逆转录酶，预防和治疗HIV感染以及预防，延缓发作或进展以及AIDS治疗。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

公开(公告)号：US20080070899A1

公开(公告)日：2008-03-20

申请号：US11664905

申请日：2005-10-05

申请人： Christopher Burgey ,  James Deng ,  Craig Potteiger ,  Theresa Williams

发明人： Christopher Burgey ,  James Deng ,  Craig Potteiger ,  Theresa Williams

IPC分类号： C07D401/14 ,  A61K31/55 ,  A61P25/06

CPC分类号： C07D491/20 ,  C07D471/10 ,  C07D471/20 ,  C07D491/10

摘要： The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I的化合物：式I：I和式II：（其中R 1，R 2，R 3， >，R 4，A，B，J，Q，T，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20070287696A1

公开(公告)日：2007-12-13

申请号：US10587121

申请日：2005-01-25

申请人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Craig Stump ,  Theresa Williams

发明人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Craig Stump ,  Theresa Williams

IPC分类号： A61K31/551 ,  A61K31/454 ,  A61K31/553 ,  A61K31/554 ,  A61P25/00 ,  A61P25/06 ,  C07D243/08 ,  C07D267/10 ,  C07D401/14

CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： Compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, D, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, pharmaceutical compositions comprising these compounds, use of these compounds and compositions to prevent or treat diseases involving CGRP.

摘要翻译： 式I化合物和式II化合物（其中R 1，R 2，R 3，R 4，R 4， >，A，B，D，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，药物组合物 包括这些化合物，使用这些化合物和组合物来预防或治疗涉及CGRP的疾病。

公开(公告)号：US20060148790A1

公开(公告)日：2006-07-06

申请号：US10562298

申请日：2004-06-24

申请人： Christopher Burgey ,  Craig Stump ,  Theresa Williams

发明人： Christopher Burgey ,  Craig Stump ,  Theresa Williams

IPC分类号： A61K31/5513 ,  C07D403/14

CPC分类号： C07D401/14

摘要： The present invention is directed to compounds of Formula I: (where variables R1, R2, R3, R6, R7, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物：其中R 1，R 2，R 3，R 6， G，J，W，X和Y如本文所定义），其可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病， 如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20070293470A1

公开(公告)日：2007-12-20

申请号：US11660798

申请日：2005-09-09

申请人： Theresa Williams ,  Christopher Burgey ,  Thomas Tucker ,  Craig Stump ,  Ian Bell

发明人： Theresa Williams ,  Christopher Burgey ,  Thomas Tucker ,  Craig Stump ,  Ian Bell

IPC分类号： A61K31/55 ,  A61K31/40 ,  A61P25/06 ,  C07D211/00 ,  C07D223/02 ,  C07D267/02 ,  C07D223/00 ,  C07D209/54 ,  A61K31/44

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D413/12 ,  C07D519/00

摘要： The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I的化合物：I（其中变量A 1，A 2，B，J，K，m，n，R 4 R 5c，R 5b和R 5c如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗 或预防CGRP所涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20070225272A1

公开(公告)日：2007-09-27

申请号：US11724066

申请日：2007-03-14

申请人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

发明人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

IPC分类号： A61K31/55 ,  C07D401/14

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物和式II化合物：其中R 1，R 2，R 3，R 3， A，B，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20060135511A1

公开(公告)日：2006-06-22

申请号：US10562297

申请日：2004-06-24

申请人： Christopher Burgey

发明人： Christopher Burgey

IPC分类号： A61K31/5513 ,  C07D403/14

CPC分类号： C07D401/14 ,  C07D471/04 ,  C07D487/04

摘要： The present invention is directed to compounds of Formula I: I (where variables R1?, R/ 2?, R3?, R 4?, R6?, R7?, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物：其中变量R 1？R / 2 ?, R 3 ?, R 4？R 6 ?, R 7 ?, G，J，Q，T，U，V，W，X和Y 可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。