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34 条记录 (耗时 0.035 秒)

    Method of identifying a modulator of a LTβR complex signaling pathway
    8.
    发明授权
    Method of identifying a modulator of a LTβR complex signaling pathway 失效
    鉴定LTbetaR复合物信号通路调节剂的方法

    公开(公告)号：US07273707B2

    公开(公告)日：2007-09-25

    申请号：US10361270

    申请日：2003-02-10

    申请人： Jun Kuai ,  Joseph L. Wooters ,  Elliott Nickbarg ,  Yongchang Qiu ,  Lih-Ling Lin

    发明人： Jun Kuai ,  Joseph L. Wooters ,  Elliott Nickbarg ,  Yongchang Qiu ,  Lih-Ling Lin

    IPC分类号： G01N33/53 ,  C07K1/00

    CPC分类号： G01N33/6863 ,  C07K14/7151 ,  G01N33/57492 ,  G01N2333/525 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2510/00

    摘要： The invention relates to compositions and methods comprising lymphotoxin-beta receptor (LTβR) modulators, which activate or inhibit LTβR signaling. LTβR modulators are useful for treating lymphocyte mediated immunological diseases and cancer, and more particularly, for regulating mitochondrial-mediated apoptosis. This invention relates to soluble forms of the LTβR complex proteins that act as LTβR activating or inhibiting agents. This invention also relates to the use of soluble molecules, directed against either the LTβR, its ligands, LIGHT and LTβ1α2, or its intracellular binding partners, that function to regulate LTβR signaling. A novel screening method for selecting soluble receptors, antibodies and other agents that modulate LTβR signaling is provided.

    摘要翻译： 本发明涉及包含激活或抑制LTbetaR信号传导的淋巴毒素-β受体（LTbetaR）调节剂的组合物和方法。 LTbetaR调节剂可用于治疗淋巴细胞介导的免疫疾病和癌症，更具体地，用于调节线粒体介导的细胞凋亡。 本发明涉及用作LTbetaR活化或抑制剂的LTbetaR复合蛋白的可溶形式。 本发明还涉及用于调节LTbetaR信号传导的功能的LTbetaR，其配体LIGHT和LTbeta1alpha2或其胞内结合配偶体的可溶性分子的用途。 提供了一种新的筛选方法，用于选择调节LTbetaR信号传导的可溶性受体，抗体和其他试剂。

    TNF receptor death domain ligand proteins and inhibitors of ligand binding
    10.
    发明授权
    TNF receptor death domain ligand proteins and inhibitors of ligand binding 失效
    TNF受体死亡域配体蛋白和配体结合抑制剂

    公开(公告)号：US07109307B2

    公开(公告)日：2006-09-19

    申请号：US09989350

    申请日：2001-11-20

    申请人： Lih-Ling Lin ,  Jennifer Chen ,  Andrea R. Schievella ,  James Graham

    发明人： Lih-Ling Lin ,  Jennifer Chen ,  Andrea R. Schievella ,  James Graham

    IPC分类号： C07K16/28

    CPC分类号： C07K14/4743 ,  A61K38/00 ,  C07K14/47 ,  C07K16/24 ,  C07K2317/34

    摘要： Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

    摘要翻译： 公开了新型TNF受体死亡结构域（“TNF-R1-DD”）配体蛋白。 还公开了编码TNF-R1-DD配体蛋白的多核苷酸以及载体，宿主细胞和制备TNF-R1-DD配体蛋白的方法。 还公开了含有TNF-R1-DD配体蛋白质的药物组合物，治疗炎性病症的方法和抑制TNF-R死亡结构域结合的方法。 还公开了鉴定TNF-R死亡结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。