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公开(公告)号：US06900186B1
公开(公告)日：2005-05-31
申请号：US09598274
申请日：2000-06-21
IPC分类号： A61K38/00 , C12N15/113 , A61K48/00 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1136 , C12N15/1138 , C12N2310/315 , C12N2310/335
摘要： The present invention relates generally to a method for the prophylaxis and/or treatment of skin disorders, and in particular proliferative and/or inflamatory skin disorders, and to genetic molecules useful for same. The present invention is particularly directed to genetic molecules capable of modulating growth factor interaction with its receptor on epidermal keratinocytes to inhibit, reduce or otherwise decrease stimulation of this layer of cells. The present invention contemplates, in a most preferred embodiment, a method for the prophylaxis and/or treatment of psoriasis.
摘要翻译： 本发明一般涉及用于预防和/或治疗皮肤病症，特别是增殖性和/或炎症性皮肤病症的方法以及对其有用的遗传分子。 本发明特别涉及能够调节与其表皮角质形成细胞上的受体的生长因子相互作用以抑制，减少或以其它方式减少对该细胞层的刺激的遗传分子。 本发明在最优选的实施方案中考虑了预防和/或治疗牛皮癣的方法。
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2.发明授权Method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders 失效用于预防和/或治疗增殖性和/或炎症性皮肤病症的方法
公开(公告)号：US5929040A
公开(公告)日：1999-07-27
申请号：US666392
申请日：1996-08-20
IPC分类号： C12N15/09 , A61K9/06 , A61K9/10 , A61K31/70 , A61K31/7088 , A61K38/18 , A61K48/00 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/475 , C12N9/22 , C12N15/11
CPC分类号： A61K31/7105 , A61K31/7088 , A61K31/711 , A61K31/7125
摘要： The present invention relates generally to a method for the prophylaxis and/or treatment of skin disorders, and in particular proliferative and/or inflammatory skin disorders, and to genetic molecules useful for same. The present invention is particularly directed to genetic molecules capable of modulating growth factor interaction with its receptor on epidermal keratinocytes to inhibit, reduce or otherwise decrease stimulation of this layer of cells. The present invention contemplates, in a most preferred embodiment, a method for the prophylaxis and/or treatment of psoriasis.
摘要翻译： PCT No.PCT / AU95 / 00410 Sec。 371日期：1996年8月20日 102（e）日期1996年8月20日PCT提交1995年7月6日PCT公布。 公开号WO96 / 01636 日期1996年1月25日本发明一般涉及用于预防和/或治疗皮肤病症，特别是增殖性和/或炎症性皮肤疾病以及对其有用的遗传分子的方法。 本发明特别涉及能够调节与其表皮角质形成细胞上的受体的生长因子相互作用以抑制，减少或以其它方式减少对该细胞层的刺激的遗传分子。 本发明在最优选的实施方案中考虑了预防和/或治疗牛皮癣的方法。
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公开(公告)号：US20130096176A1
公开(公告)日：2013-04-18
申请号：US13493827
申请日：2012-06-11
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition.
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公开(公告)号：US20090286849A1
公开(公告)日：2009-11-19
申请号：US12342025
申请日：2008-12-22
IPC分类号： A61K31/711 , C07H21/00 , C12Q1/68 , G01N33/68 , A61P17/06
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition.
摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，该化合物可用于涉及IGF-1R的任何其它病症，包括炎症状况。
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5.发明授权Method for the prophylaxis and/or treatment of proliferative and /or inflammatory skin disorders 失效用于预防和/或治疗增殖性和/或炎症性皮肤病症的方法公开(公告)号：US06284741B1
公开(公告)日：2001-09-04
申请号：US09199926
申请日：1998-11-25
IPC分类号： A61K317088
CPC分类号： A61K31/7105 , A61K31/7088 , A61K31/711 , A61K31/7125
摘要： The present invention relates generally to a method for the prophylaxis and/or treatment of skin disorders, and in particular proliferative and/or inflammatory skin disorders, and to genetic molecules useful for same. The present invention is particularly directed to genetic molecules capable of modulating growth factor interaction with its receptor on epidermal keratinocytes to inhibit, reduce or otherwise decrease stimulation of this layer of cells. The present invention contemplates, in a most preferred embodiment, a method for the prophylaxis and/or treatment of psoriasis.
摘要翻译： 本发明一般涉及用于预防和/或治疗皮肤病症，特别是增殖性和/或炎症性皮肤疾病以及对其有用的遗传分子的方法。 本发明特别涉及能够调节与其表皮角质形成细胞上的受体的生长因子相互作用以抑制，减少或以其它方式减少对该细胞层的刺激的遗传分子。 本发明在最优选的实施方案中考虑了预防和/或治疗牛皮癣的方法。
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公开(公告)号：US20080286287A1
公开(公告)日：2008-11-20
申请号：US11910406
申请日：2006-03-30
IPC分类号： A61K39/395 , C12N5/06 , A61K38/02 , A61P35/00 , A61K31/7052
CPC分类号： A61K38/1709 , A61K38/39
摘要： The present invention discloses the use of modified IGFBP-2 and agents that regulate the interaction between HBD of IGFBP-2 and EC or PC matrix components to prevent cellular proliferation invasion and/or migration (metastases).
摘要翻译： 本发明公开了使用修饰的IGFBP-2和调节IGFBP-2的HBD与EC或PC基质组分之间的相互作用以防止细胞增殖侵袭和/或迁移（转移）的试剂。
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公开(公告)号：US07468356B2
公开(公告)日：2008-12-23
申请号：US10545354
申请日：2004-02-11
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.
摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，所述化合物可用于涉及IGF-1R的任何其它病症，包括炎性病症。
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