公开(公告)号：US20160024079A1

公开(公告)日：2016-01-28

申请号：US14774430

申请日：2014-03-13

申请人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Liang XUE ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

发明人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Liang XUE ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.

摘要翻译： 本发明提供了式（I）化合物：其中X为N或CH，Y为NH，O或S，制备这些化合物的方法及其作为因子B抑制剂用于治疗与补体相关的病症和疾病的用途 替代途径激活如年龄相关性黄斑变性，糖尿病性视网膜病变和相关眼科疾病。 本发明还提供药物组合物和药理活性剂的组合。

公开(公告)号：US20150250767A1

公开(公告)日：2015-09-10

申请号：US14715594

申请日：2015-05-19

申请人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Liang XUE ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

发明人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Liang XUE ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

IPC分类号： A61K31/4184 ,  A61K31/4439 ,  A61K31/4245

CPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D403/14 ,  C07D413/06 ,  C07D413/14 ,  C07D487/04 ,  C07D491/048

摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20130296377A1

公开(公告)日：2013-11-07

申请号：US13826725

申请日：2013-03-14

申请人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Xue LIANG ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

发明人： Christopher Michael ADAMS ,  Charles BABU ,  Michael Paul CAPPARELLI ,  Jian DING ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Xue LIANG ,  Nello MAINOLFI ,  James J. POWERS ,  Michael H. SERRANO-WU ,  Chun ZHANG

IPC分类号： C07D491/048 ,  A61K31/4184 ,  C07D413/06 ,  A61K45/06 ,  C07D403/14 ,  C07D401/14 ,  A61K31/4439 ,  C07D403/06 ,  A61K31/423

CPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D403/14 ,  C07D413/06 ,  C07D413/14 ,  C07D487/04 ,  C07D491/048

摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20170197940A1

公开(公告)日：2017-07-13

申请号：US15320810

申请日：2015-07-02

申请人： Christopher M. ADAMS ,  Doug BEVAN ,  Michael Paul CAPPARELLI ,  Takeru EHARA ,  Luciana FERRARA ,  Nan JI ,  Mitsunori KATO ,  Nello MAINOLFI ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA

发明人： Christopher M. ADAMS ,  Doug BEVAN ,  Michael Paul CAPPARELLI ,  Takeru EHARA ,  Luciana FERRARA ,  Nan JI ,  Mitsunori KATO ,  Nello MAINOLFI ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA

IPC分类号： C07D401/14 ,  C07D401/12 ,  A61K31/454 ,  C07D413/14 ,  A61K31/4725 ,  A61K31/4439 ,  C07D405/14 ,  A61K9/00 ,  A61K31/4545

CPC分类号： C07D401/14 ,  A61K9/0048 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  C07D401/10 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.