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公开(公告)号：US20160024079A1
公开(公告)日：2016-01-28
申请号：US14774430
申请日：2014-03-13
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.
摘要翻译： 本发明提供了式（I）化合物：其中X为N或CH，Y为NH，O或S，制备这些化合物的方法及其作为因子B抑制剂用于治疗与补体相关的病症和疾病的用途 替代途径激活如年龄相关性黄斑变性，糖尿病性视网膜病变和相关眼科疾病。 本发明还提供药物组合物和药理活性剂的组合。
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公开(公告)号：US20150250767A1
公开(公告)日：2015-09-10
申请号：US14715594
申请日：2015-05-19
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/4245
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US20130296377A1
公开(公告)日：2013-11-07
申请号：US13826725
申请日：2013-03-14
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Xue LIANG , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Xue LIANG , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： C07D491/048 , A61K31/4184 , C07D413/06 , A61K45/06 , C07D403/14 , C07D401/14 , A61K31/4439 , C07D403/06 , A61K31/423
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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4.发明申请公开(公告)号：US20160311779A1
公开(公告)日：2016-10-27
申请号：US15032872
申请日：2014-10-29
申请人： Christopher ADAMS , Takeru EHARA , Keith JENDZA , Nan JI , Toshio KAWANAMI , Nello MAINOLFI , James J. POWERS , Michael SERRANO-WU , Chun ZHANG , Rajeshri Ganesh KARKI
发明人： Christopher ADAMS , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Nello MAINOLFI , James POWERS , Michael Serrano-WU , Chun ZHANG
IPC分类号： C07D235/12 , C07D235/14
CPC分类号： C07D235/12 , A61K31/4184 , A61K45/06 , C07D235/14 , A61K2300/00
摘要： The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物，其用于制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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5.发明申请公开(公告)号：US20170197940A1
公开(公告)日：2017-07-13
申请号：US15320810
申请日：2015-07-02
申请人： Christopher M. ADAMS , Doug BEVAN , Michael Paul CAPPARELLI , Takeru EHARA , Luciana FERRARA , Nan JI , Mitsunori KATO , Nello MAINOLFI , Erik MEREDITH , Muneto MOGI , James J. POWERS , Ganesh PRASANNA
发明人： Christopher M. ADAMS , Doug BEVAN , Michael Paul CAPPARELLI , Takeru EHARA , Luciana FERRARA , Nan JI , Mitsunori KATO , Nello MAINOLFI , Erik MEREDITH , Muneto MOGI , James J. POWERS , Ganesh PRASANNA
IPC分类号： C07D401/14 , C07D401/12 , A61K31/454 , C07D413/14 , A61K31/4725 , A61K31/4439 , C07D405/14 , A61K9/00 , A61K31/4545
CPC分类号： C07D401/14 , A61K9/0048 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , C07D401/10 , C07D401/12 , C07D405/14 , C07D413/14
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US20130005750A1
公开(公告)日：2013-01-03
申请号：US13613019
申请日：2012-09-13
申请人： Gerald David ARTMAN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
发明人： Gerald David ARTMAN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
IPC分类号： C07D471/04 , A61P27/02 , A61K31/519
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号：US20120245187A1
公开(公告)日：2012-09-27
申请号：US13488760
申请日：2012-06-05
申请人： Gerald David ARTMANN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
发明人： Gerald David ARTMANN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
IPC分类号： A61K31/519 , A61P27/02 , A61P9/10 , C07D471/04
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号：US20130012529A1
公开(公告)日：2013-01-10
申请号：US13613062
申请日：2012-09-13
申请人： Gerald David ARTMAN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
发明人： Gerald David ARTMAN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
IPC分类号： C07D413/14 , A61P27/02 , A61P9/10 , A61K31/506
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
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公开(公告)号：US20130005753A1
公开(公告)日：2013-01-03
申请号：US13613053
申请日：2012-09-13
申请人： Gerald David ARTMAN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
发明人： Gerald David ARTMAN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
IPC分类号： C07D403/14 , A61P27/02 , A61K31/506
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
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公开(公告)号：US20130005751A1
公开(公告)日：2013-01-03
申请号：US13613034
申请日：2012-09-13
申请人： Gerald David ARTMAN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
发明人： Gerald David ARTMAN, III , Jason Matthew ELLIOTT , Nan JI , Donglei LIU , Fupeng MA , Nello MAINOLFI , Erik MEREDITH , Karl MIRANDA , James J. POWERS , Chang RAO
IPC分类号： C07D471/04 , A61P27/02 , A61K31/519
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
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