公开(公告)号：US07759384B2

公开(公告)日：2010-07-20

申请号：US11767581

申请日：2007-06-25

申请人： Christopher S. Brook ,  Wei Chen ,  Philip C. Dell'orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

发明人： Christopher S. Brook ,  Wei Chen ,  Philip C. Dell'orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

IPC分类号： A61K31/40 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂合物治疗高血压，充血性心力衰竭和 心绞痛等

公开(公告)号：US07750036B2

公开(公告)日：2010-07-06

申请号：US10997230

申请日：2004-11-24

申请人： Christopher S. Brook ,  Pingyun Y. Chen ,  Wei Chen ,  Qunying Dai ,  Philip C. Dell'Orco ,  Clifford S. Labaw ,  Ann Marie Diederich ,  Choon K. Oh ,  Claire Hisler ,  David H. Igo ,  Lee M. Katrincic ,  Li-Jen Ping ,  Paul G. Spoors ,  Jun Wang ,  Christopher Werner

发明人： Christopher S. Brook ,  Pingyun Y. Chen ,  Wei Chen ,  Qunying Dai ,  Philip C. Dell'Orco ,  Clifford S. Labaw ,  Ann Marie Diederich ,  Choon K. Oh ,  Claire Hisler ,  David H. Igo ,  Lee M. Katrincic ,  Li-Jen Ping ,  Paul G. Spoors ,  Jun Wang ,  Christopher Werner

IPC分类号： A61K31/403 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man.The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛和/或其相应溶剂合物的盐，含有这种卡维地洛和/或其相应溶剂化物的组合物和/或使用上述化合物治疗哺乳动物某些疾病状态的方法， 特别的人 本发明还涉及卡维地洛磷酸盐和/或其溶剂合物，其包括新颖的卡维地洛磷酸二氢盐结晶形式（即它是1-（咔唑-4-基氧基-3 - [[2 - （邻甲氧基苯氧基）乙基]氨基] -2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其它相应的溶剂合物，含有这些卡维地洛磷酸盐和/或溶剂化物的组合物，以及使用上述 盐和/或溶剂化物治疗高血压，充血性心力衰竭和心绞痛等

公开(公告)号：US07626041B2

公开(公告)日：2009-12-01

申请号：US11767573

申请日：2007-06-25

申请人： Christopher S. Brook ,  Wei Chen ,  Philip C. Dell'orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

发明人： Christopher S. Brook ,  Wei Chen ,  Philip C. Dell'orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

IPC分类号： C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂合物治疗高血压，充血性心力衰竭和 心绞痛等

公开(公告)号：US07902378B2

公开(公告)日：2011-03-08

申请号：US11767586

申请日：2007-06-25

申请人： Christopher S. Brook ,  Wei Chen ,  Philip C. Dell'Orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

发明人： Christopher S. Brook ,  Wei Chen ,  Philip C. Dell'Orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

IPC分类号： C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂合物治疗高血压，充血性心力衰竭和 心绞痛等

公开(公告)号：US07893100B2

公开(公告)日：2011-02-22

申请号：US11767578

申请日：2007-06-25

申请人： Christopher S. Brook ,  Wei Chen ,  Philip C. Dell'Orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

发明人： Christopher S. Brook ,  Wei Chen ,  Philip C. Dell'Orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

IPC分类号： C07D209/88 ,  A61K31/403

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

公开(公告)号：US20080262069A1

公开(公告)日：2008-10-23

申请号：US11767578

申请日：2007-06-25

申请人： Christopher S. BROOK ,  Wei Chen ,  Phillip C. Dell'Orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

发明人： Christopher S. BROOK ,  Wei Chen ,  Phillip C. Dell'Orco ,  Lee M. Katrincic ,  Ann Marie Louvet ,  Choon K. Oh ,  Paul G. Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  C07D209/88 ,  A61P9/12

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂合物治疗高血压，充血性心力衰竭和 心绞痛等

公开(公告)号：US07268156B2

公开(公告)日：2007-09-11

申请号：US10518654

申请日：2003-06-27

申请人： Christopher S. Brook ,  Wei Chen ,  Paul G. Spoors

发明人： Christopher S. Brook ,  Wei Chen ,  Paul G. Spoors

IPC分类号： C07D209/88 ,  A61K31/403

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂合物治疗高血压，充血性心力衰竭和 心绞痛等

公开(公告)号：US12077787B2

公开(公告)日：2024-09-03

申请号：US17469899

申请日：2021-09-09

申请人： Haiqin Chen ,  Wei Chen ,  Xin Tang ,  Jun Cao ,  Jianxin Zhao ,  Yongquan Chen ,  Hao Zhang

发明人： Haiqin Chen ,  Wei Chen ,  Xin Tang ,  Jun Cao ,  Jianxin Zhao ,  Yongquan Chen ,  Hao Zhang

IPC分类号： C12N9/10 ,  C12P7/6445

CPC分类号： C12N9/1029 ,  C12P7/6445 ,  C12Y203/0102

摘要： Disclosed is a diacylglycerol acyltransferase 1, a recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1, and application thereof in production of triacylglycerol. The diacylglycerol acyltransferase 1 of the invention has a function of catalyzing synthesis of triacylglycerol. After the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 of the invention is subjected to induction culture for 48 h, the content of total fatty acid and triacylglycerol in the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 can be respectively increased by 1.94 folds and 12.09 folds as compared with those of Saccharomyces cerevisiae without the recombinant diacylglycerol acyltransferase 1. The instant invention provides a method for improving the ability of microorganisms to produce polyunsaturated fatty acids (PUFAs) by means of genetic engineering.

公开(公告)号：US20220316281A1

公开(公告)日：2022-10-06

申请号：US17223127

申请日：2021-04-06

申请人： Farhat Shaikh ,  Navin Sakthivel ,  Aaron Avagliano ,  Wei Chen

发明人： Farhat Shaikh ,  Navin Sakthivel ,  Aaron Avagliano ,  Wei Chen

IPC分类号： E21B17/00 ,  H01B1/18 ,  C04B37/02 ,  C04B37/00

摘要： An electrically conductive ceramic composite conductor configured for downhole operations includes a first portion formed from an electrically non-conductive ceramic material having a first coefficient of thermal expansion (CTE). The first portion includes an outer surface. A second portion is disposed radially inwardly of the outer surface. The second portion is formed from an electrically conductive ceramic material having a second CTE that is substantially similar to the first CTE.

公开(公告)号：USD962002S1

公开(公告)日：2022-08-30

申请号：US29808797

申请日：2021-09-23

申请人： Wei Chen

设计人： Wei Chen