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1.发明申请Aminocyclohexanes and Aminotetrahydropyrans and Related Compounds As Gamma-Secretase Modulators 审中-公开氨基环己烷和氨基四氢吡喃和相关化合物作为γ分泌酶调节剂公开(公告)号：US20120295923A1
公开(公告)日：2012-11-22
申请号：US13575370
申请日：2011-01-19
申请人： Christopher William Am Ende , Benjamin Adam Fish , Douglas Scott Johnson , Ricardo Lira , Christopher John O'Donnell , Martin Youngjin Pettersson , Corey Michael Stiff
发明人： Christopher William Am Ende , Benjamin Adam Fish , Douglas Scott Johnson , Ricardo Lira , Christopher John O'Donnell , Martin Youngjin Pettersson , Corey Michael Stiff
IPC分类号： A61K31/505 , A61K31/196 , A61K31/421 , C07D263/32 , C07D309/14 , A61K31/35 , C07D239/26 , C07D277/30 , A61K31/426 , A61K31/438 , C07D221/20 , C07D221/22 , A61K31/439 , A61K31/4433 , C07D405/04 , C07D213/55 , A61K31/4418 , A61P25/00 , A61P25/18 , C07C229/42
CPC分类号： C07C229/46 , C07C255/24 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07D213/55 , C07D221/20 , C07D221/22 , C07D239/26 , C07D263/32 , C07D271/12 , C07D275/02 , C07D277/28 , C07D307/52 , C07D307/79 , C07D309/04 , C07D309/14 , C07D311/04 , C07D405/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中化合物具有说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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公开(公告)号：US20120252758A1
公开(公告)日：2012-10-04
申请号：US13433452
申请日：2012-03-29
申请人： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William Am Ende , Benjamin Adam Fish , Michael Eric Green , Patrick Bradley Mullins , Cory Michael Stiff , Tuan Phong Tran , Thayalan Navaratnam
发明人： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William Am Ende , Benjamin Adam Fish , Michael Eric Green , Patrick Bradley Mullins , Cory Michael Stiff , Tuan Phong Tran , Thayalan Navaratnam
IPC分类号： A61K31/4985 , C07F7/10 , A61K31/695 , C07D401/04 , A61P25/00 , A61P25/18 , A61P25/28 , C07D471/04 , A61K31/551
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/695 , A61K45/06 , C07D401/04 , C07D491/048 , C07F7/0812
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有如本文所定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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公开(公告)号：US08697673B2
公开(公告)日：2014-04-15
申请号：US13433452
申请日：2012-03-29
申请人： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Benjamin Adam Fish , Michael Eric Green , Patrick Bradley Mullins , Cory Michael Stiff , Tuan Phong Tran , Thayalan Navaratnam
发明人： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Benjamin Adam Fish , Michael Eric Green , Patrick Bradley Mullins , Cory Michael Stiff , Tuan Phong Tran , Thayalan Navaratnam
IPC分类号： A61K31/551 , A61K31/695 , A61K31/4985 , A61P25/00 , A61P25/18 , A61P25/28 , C07D401/04 , C07D471/04 , C07F7/10
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/695 , A61K45/06 , C07D401/04 , C07D491/048 , C07F7/0812
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有如本文所定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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4.发明申请Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators 审中-公开新型杂芳基咪唑和杂芳基三唑作为γ-分泌酶调节剂公开(公告)号：US20120202787A1
公开(公告)日：2012-08-09
申请号：US13501326
申请日：2010-10-12
申请人： Christopher William am Ende , Douglas Scott Johnson , Martin Youngjin Pettersson , Chakrapani Subramanyam , Christopher John O'Donnell
发明人： Christopher William am Ende , Douglas Scott Johnson , Martin Youngjin Pettersson , Chakrapani Subramanyam , Christopher John O'Donnell
IPC分类号： A61K31/4439 , C07D403/04 , A61K31/497 , C07D401/04 , A61P25/28 , C07D413/14 , C07D417/14 , C07D401/14 , C07D409/14 , A61P25/00 , C07D405/14 , C07D403/14
CPC分类号： C07D403/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构; 如说明书中所定义。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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5.发明申请Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof 审中-公开氧哌啶基和吡喃磺酰胺及其药物组合物公开(公告)号：US20110172297A1
公开(公告)日：2011-07-14
申请号：US13061684
申请日：2009-09-18
申请人： Kimberly Gail Estep , Antone F.J. Fliri , Randall James Gallaschun , Christopher John O'Donnell , Nandini Chaturbhai Patel , Jacob Bradley Schwarz , Longfei Xie
发明人： Kimberly Gail Estep , Antone F.J. Fliri , Randall James Gallaschun , Christopher John O'Donnell , Nandini Chaturbhai Patel , Jacob Bradley Schwarz , Longfei Xie
IPC分类号： A61K31/351 , C07D309/14 , C07D409/10 , C07D405/10 , C07D211/56 , A61K31/381 , A61P25/00 , A61P25/28 , A61P9/10 , A61P27/02 , A61P25/16 , A61P25/08 , A61P25/06 , A61P25/18 , A61P25/22
CPC分类号： C07D211/76 , C07D309/14 , C07D405/10 , C07D409/10
摘要： The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of Formula (I): as defined in the specification. The invention is also directed to compositions containing the compounds of Formula (I) as AMPA modulators.
摘要翻译： 本发明涉及一类化合物，包括具有式（I）结构的化合物的药学上可接受的盐：如说明书中所定义的。 本发明还涉及含有式（I）化合物作为AMPA调节剂的组合物。
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公开(公告)号：US08278457B2
公开(公告)日：2012-10-02
申请号：US12823224
申请日：2010-06-25
申请人： Anton F. J. Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara E. Segelstein
发明人： Anton F. J. Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara E. Segelstein
IPC分类号： C07D291/00 , A61K31/335
CPC分类号： C07D409/14 , C07C307/02 , C07C311/07 , C07C2601/08 , C07C2601/14 , C07D207/08 , C07D213/65 , C07D295/096 , C07D307/22 , C07D307/42 , C07D333/38 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12
摘要： The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
摘要翻译： 本发明涉及一类化合物，包括具有式I结构的化合物的药学上可接受的盐：如说明书中所定义的。 本发明还涉及包含和使用式I化合物的组合物。
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公开(公告)号：US20110178165A1
公开(公告)日：2011-07-21
申请号：US13122047
申请日：2009-09-25
IPC分类号： A61K31/381 , C07D307/02 , A61K31/34 , C07D409/10 , A61P25/00 , A61P25/18 , A61P9/00 , A61P25/28 , A61P25/16 , A61P21/00 , A61P25/08 , A61P25/06 , A61P1/00 , A61P25/30 , A61P25/22 , A61P27/16 , A61P27/02 , A61P25/20
CPC分类号： C07D307/22 , C07D409/10
摘要： The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I): as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I). They are useful in the treatment of CNS disorders.
摘要翻译： 本发明涉及一类化合物，包括具有式（I）结构的化合物的药学上可接受的盐：如说明书中所定义的。 本发明还涉及含有式（I）化合物的组合物。 它们可用于治疗CNS疾病。
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公开(公告)号：US08686043B2
公开(公告)日：2014-04-01
申请号：US13596492
申请日：2012-08-28
申请人： Anton Franz Joseph Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara Eileen Segelstein
发明人： Anton Franz Joseph Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara Eileen Segelstein
CPC分类号： C07D409/14 , C07C307/02 , C07C311/07 , C07C2601/08 , C07C2601/14 , C07D207/08 , C07D213/65 , C07D295/096 , C07D307/22 , C07D307/42 , C07D333/38 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12
摘要： The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
摘要翻译： 本发明涉及一类化合物，包括具有式I结构的化合物的药学上可接受的盐：如说明书中所定义的。 本发明还涉及包含和使用式I化合物的组合物。
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公开(公告)号：US20120322823A1
公开(公告)日：2012-12-20
申请号：US13596492
申请日：2012-08-28
申请人： Anton F. J. Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara E. Segelstein
发明人： Anton F. J. Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara E. Segelstein
IPC分类号： A61K31/40 , A61K31/381 , A61K31/275 , A61K31/4436 , A61K31/443 , A61K31/18 , A61K31/4709 , A61P25/00 , A61P25/18 , A61P25/28 , A61P25/16 , A61P27/00 , A61P25/08 , A61P25/06 , A61K31/341
CPC分类号： C07D409/14 , C07C307/02 , C07C311/07 , C07C2601/08 , C07C2601/14 , C07D207/08 , C07D213/65 , C07D295/096 , C07D307/22 , C07D307/42 , C07D333/38 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12
摘要： The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
摘要翻译： 本发明涉及一类化合物，包括具有式I结构的化合物的药学上可接受的盐：如说明书中所定义的。 本发明还涉及包含和使用式I化合物的组合物。
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公开(公告)号：US20110105533A1
公开(公告)日：2011-05-05
申请号：US12823224
申请日：2010-06-25
申请人： Anton F. J. Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara E. Segelstein
发明人： Anton F. J. Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara E. Segelstein
IPC分类号： A61K31/506 , C07D307/22 , C07D405/12 , C07D409/12 , C07C307/02 , C07D333/38 , A61K31/4025 , A61K31/381 , A61K31/18 , A61K31/443 , A61K31/341 , A61P25/28 , A61P25/00 , A61P9/00 , A61P27/02 , A61P25/08 , A61P25/16 , A61P25/30 , A61P25/06 , A61P1/08 , A61P7/10 , A61P25/18 , A61P13/00 , A61P25/22 , A61P27/16 , A61P21/00
CPC分类号： C07D409/14 , C07C307/02 , C07C311/07 , C07C2601/08 , C07C2601/14 , C07D207/08 , C07D213/65 , C07D295/096 , C07D307/22 , C07D307/42 , C07D333/38 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12
摘要： The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
摘要翻译： 本发明涉及一类化合物，包括具有式I结构的化合物的药学上可接受的盐：如说明书中所定义的。 本发明还涉及包含和使用式I化合物的组合物。
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