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    Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
    6.
    发明授权
    Indol-3-YL-2-oxoacetamide compounds and methods of use thereof 有权

    公开(公告)号：US06903104B2

    公开(公告)日：2005-06-07

    申请号：US10310711

    申请日：2002-12-05

    申请人： Chiung-Tong Chen ,  Shu-Jen Chen ,  Ming-Chu Hsu ,  Der-Ren Hwang ,  Wen-Tai Li ,  Chu-Chung Lin

    发明人： Chiung-Tong Chen ,  Shu-Jen Chen ,  Ming-Chu Hsu ,  Der-Ren Hwang ,  Wen-Tai Li ,  Chu-Chung Lin

    IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/405 ,  C07D407/12 ,  C07D413/12

    CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

    摘要： The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following formula. In this formula, each R1 is independently isoxazolyl, thiazolyl, isothiazolyl, 1,3,4-thiadiazolyl, 1,3-benzothiazolyl, quinolyl, isoquinolyl, thionaphthenyl, or benzofuranyl, each being optionally substituted with 1-6 independent R5; or when taken together with R2 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R2 is independently H, C1-C10 alkyl, or aryl, each being optionally substituted with 1-4 independent R5; or when taken together with R1 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R3 is independently C3-C10 cycloalkyl, C4-C10 cycloalkenyl, isoxazolyl, furanyl, thiophenyl, thiazolyl, imidazolyl, pyridyl, or heterocyclyl, each being optionally substituted with 1-4 independent R5. Each R4 is independently H, NO2, halo, CN, R7, OR7, CO2R7, SR7, NR7R7, C(O)R7, C(O)NR7R7, OC(O)R7, S(O)2R7, S(O)2NR7R7, NR7C(O)NR7R7, NR7C(O)R7, NR7(COOR7), NR7S(O)2NR7R7, NR7S(O)2R7, or S(O)2OR7.