公开(公告)号：US20060178260A1

公开(公告)日：2006-08-10

申请号：US11051777

申请日：2005-02-04

申请人： Chuan-Jian Zhong ,  Jin Luo ,  Mathew Maye ,  Nancy Kariuki

发明人： Chuan-Jian Zhong ,  Jin Luo ,  Mathew Maye ,  Nancy Kariuki

IPC分类号： B01J21/18 ,  B22F9/00 ,  C22C5/00 ,  C22C5/04 ,  C22C5/02

CPC分类号： B22F9/24 ,  B22F2998/00 ,  B82Y30/00 ,  C22B5/00 ,  C22B11/04 ,  C22C5/02 ,  C22C5/04 ,  H01M4/8615 ,  H01M4/92 ,  H01M4/925 ,  H01M4/926 ,  H01M8/1011 ,  Y02E60/523 ,  B22F1/0018

摘要： A method is featured for fabricating Carbon-supported AuPt nanoparticle catalysts for fuel cells, and particularly fuel cells using methanol as the fuel. The method prepares AuPt-based fuel cell catalysts having a wide range of controllable Au:Pt ratios. The AuPt catalysis are supportable on both carbon black (C) and C/TiO2 support materials. These materials demonstrate electro-catalytic activity towards CO and methanol oxidation, and O2 reduction. The same catalyst material is useful in constructing both anodes and cathodes, and demonstrates bifunctional activity.

摘要翻译： 一种用于制造用于燃料电池的碳载体AuPt纳米颗粒催化剂的方法，特别是使用甲醇作为燃料的燃料电池。 该方法制备具有宽范围可控的Au：Pt比率的基于AuPt的燃料电池催化剂。 AuPt催化剂可以在炭黑（C）和C / TiO 2 2载体材料上都是可以支持的。 这些材料表现出对CO和甲醇氧化以及O 2还原的电催化活性。 相同的催化剂材料可用于构建阳极和阴极，并显示双功能活性。

公开(公告)号：US20050235776A1

公开(公告)日：2005-10-27

申请号：US10944461

申请日：2004-09-17

申请人： Ting He ,  Chuan-Jian Zhong ,  Jin Luo ,  Mathew Maye ,  Li Han ,  Nancy Kariuki ,  Lingyan Wang

发明人： Ting He ,  Chuan-Jian Zhong ,  Jin Luo ,  Mathew Maye ,  Li Han ,  Nancy Kariuki ,  Lingyan Wang

IPC分类号： B22F1/00 ,  B22F1/02 ,  B22F9/20 ,  B22F9/24

CPC分类号： B22F9/24 ,  B22F1/0018 ,  B22F1/0088 ,  B82Y30/00 ,  Y10S977/896

摘要： The present teachings are directed toward single metal and alloy nanoparticles and synthesis methods for preparing single metal and alloy nanoparticles.

摘要翻译： 本教导涉及单金属和合金纳米颗粒以及用于制备单一金属和合金纳米颗粒的合成方法。

公开(公告)号：US11103923B2

公开(公告)日：2021-08-31

申请号：US15776879

申请日：2016-11-18

申请人： Mathew Maye

发明人： Mathew Maye

IPC分类号： B32B5/16 ,  B22F1/02 ,  B22F1/00 ,  B82Y30/00 ,  B82Y40/00 ,  C22C38/08 ,  C22C38/10 ,  C22C32/00 ,  C22C38/00 ,  B22F7/02 ,  B22F7/00

摘要： A nanoparticle with tunable radial gradients of compositions extending from the center of the nanoparticles. The nature of the gradient preserves the metallic state of the nanoparticles, the diffusion of the constituents, and the oxidation of the interface. The gradients can be purposely varied to allow for specific applications in fields ranging from corrosion, magnetics, information technology, imaging, electromagnetic absorption, coating technologies, and immuno-precipitation. The nanoparticles can be easily used to advance many areas of industry, technology, and life sciences.

公开(公告)号：US20180326479A1

公开(公告)日：2018-11-15

申请号：US15776879

申请日：2016-11-18

申请人： Mathew Maye

发明人： Mathew Maye

IPC分类号： B22F1/02 ,  B22F1/00 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： B22F1/025 ,  B22F1/0018 ,  B22F1/0085 ,  B22F7/00 ,  B22F7/02 ,  B22F2301/35 ,  B22F2999/00 ,  B82Y30/00 ,  B82Y40/00 ,  C22C32/0094 ,  C22C38/00 ,  C22C38/08 ,  C22C38/10 ,  C22C2202/02 ,  B22F2207/01

摘要： A nanoparticle with tunable radial gradients of compositions extending from the center of the nanoparticles. The nature of the gradient preserves the metallic state of the nanoparticles, the diffusion of the constituents, and the oxidation of the interface. The gradients can be purposely varied to allow for specific applications in fields ranging from corrosion, magnetics, information technology, imaging, electromagnetic absorption, coating technologies, and immuno-precipitation. The nanoparticles can be easily used to advance many areas of industry, technology, and life sciences.

公开(公告)号：US20180284086A1

公开(公告)日：2018-10-04

申请号：US15756657

申请日：2016-08-30

申请人： Mathew Maye ,  Tennyson Doane

发明人： Mathew Maye ,  Tennyson Doane

IPC分类号： G01N31/22 ,  G01N21/64

摘要： A nanoparticle based assay for monitoring chemical reactions in real-time, ion concentrations in solution, and oxidation potential of ions in solution is describe. The assay is based on use of photoluminescent perovskite nanoparticles with the composition XYZ3. The XYZ3 nanoparticles are added to a reaction or a solution to be analyzed, and the optoelectronic response of the nanoparticle is proportional to the chemical kinetics of the reaction or concentration of target. The resulting color changes can be qualitatively monitored by eye or quantitatively by spectroscopy. The assays may serve as a compliment or replacement for routine chemical analysis performed over the course of a reaction.

公开(公告)号：US20120141550A1

公开(公告)日：2012-06-07

申请号：US13286847

申请日：2011-11-01

申请人： Mathew Maye ,  James Dabrowiak ,  Colleen Alexander

发明人： Mathew Maye ,  James Dabrowiak ,  Colleen Alexander

IPC分类号： A61K9/14 ,  C07H1/00 ,  A61K31/7135 ,  B32B5/16 ,  C07H21/00 ,  A61P35/00 ,  B82B3/00 ,  B82B1/00 ,  B82Y5/00

CPC分类号： A61K31/7042 ,  A61K47/6923 ,  Y10T428/2982

摘要： System and method for loading the front line anticancer drug, doxorubicin (DOX) onto DNA-capped gold nanoparticles whose duplex DNA has been designed for specific DOX intercalation. Since each AuNP contains about 108 high affinity drug sites, this design allows for a high local DOX concentration on the particle. Drug binding was confirmed by monitoring the increase in DNA melting temperature, the shift in the plasmon resonance maximum, and the increase in the NP hydrodynamic radius as a function of [DOX]/[DNA] ratio. The feasibility of the nanoparticles as a drug delivery system was demonstrated by showing that particle-bound DOX could be transferred to a target DNA.

摘要翻译： 将前线抗癌药物多柔比星（DOX）加载到DNA封端的金纳米颗粒上的系统和方法，其双链DNA已被设计用于特定的DOX插层。 由于每个AuNP含有约108个高亲和力的药物部位，因此该设计允许颗粒上的高的局部DOX浓度。 通过监测DNA熔解温度的升高，等离子体共振最大值的移动和作为[DOX] / [DNA]比率的函数的NP流体动力学半径的增加来证实药物结合。 通过显示粒子结合的DOX可以转移到靶DNA来证明纳米颗粒作为药物递送系统的可行性。

公开(公告)号：US20120114962A1

公开(公告)日：2012-05-10

申请号：US13291376

申请日：2011-11-08

申请人： Mathew Maye ,  Peter Njoki ,  Wenjie Wu ,  Hyunjoo Han

发明人： Mathew Maye ,  Peter Njoki ,  Wenjie Wu ,  Hyunjoo Han

IPC分类号： B32B15/01 ,  B22F9/16

CPC分类号： C22C5/06 ,  B22F1/0018 ,  B22F1/025 ,  B22F9/24 ,  B22F2998/00 ,  B32B15/018 ,  B82Y30/00 ,  C22C5/02 ,  C22C5/04 ,  Y10T428/12181 ,  B22F2202/11

摘要： A system and method to tailor the optical properties of nanomaterials using a core-alloy-shell nano-ultrastructure. Atomic diffusion is used at the nanoscale in order to process as-synthesized nanomaterials into core-alloy-shell architectures. The alloy formation is controlled by the deposition of the alloy solute atoms, and then by alloy interdiffusion of the solute into the core nanoparticle. By controlling temperature, it is possible to control how far the solute diffuses into the core, which in turn allows the tailoring of the optical response of the particle itself. The alloy formation and subsequent interdiffusion allows tailoring of the nanoparticle composition and ultrastructure, resulting in a dramatic tunability of the metal nanostructures surface plasmon response.

摘要翻译： 一种使用核 - 合金 - 壳纳米超微结构定制纳米材料的光学性质的系统和方法。 原子扩散用于纳米级，以便将合成纳米材料加工成核 - 合金 - 壳结构。 合金形成由合金溶质原子的沉积控制，然后通过合金相互扩散溶质进入核心纳米颗粒。 通过控制温度，可以控制溶质扩散到芯中的距离，这又允许调整颗粒本身的光学响应。 合金形成和随后的相互扩散允许调整纳米颗粒组成和超微结构，导致金属纳米结构表面等离子体激元响应的显着的可调性。

公开(公告)号：US09758808B1

公开(公告)日：2017-09-12

申请号：US14073463

申请日：2013-11-06

申请人： Mathew Maye ,  Rabeka Alam

发明人： Mathew Maye ,  Rabeka Alam

IPC分类号： A61K49/00 ,  C12Q1/66

CPC分类号： C12Q1/66 ,  A61K49/00 ,  A61K49/0013 ,  A61K49/0067 ,  C12Q2521/543

摘要： A bioluminescence energy transfer (BRET) nanosystem having semiconductive quantum rods (QRs) bound by firefly luciferase Photinus pyralis (Ppy) for improved conversion of chemical energy to light, such as in solid-state lighting, near-infrared imaging systems, and in vivo infrared imaging. The nanosystems are formed by synthesizing CdSe/CdS or CdSe/CdS/ZnS quantum rods, rendering the dots hydrophilic and colloidially stable with a facile His-capping, incubating with a Ppy variant (PpyGRTS) at increasing loading ratios, and adding an excess of the luciferin (LH2) substrate to the PpyGRTS-QRs.

公开(公告)号：US08632789B2

公开(公告)日：2014-01-21

申请号：US13286847

申请日：2011-11-01

申请人： Mathew Maye ,  James Dabrowiak ,  Colleen Alexander

发明人： Mathew Maye ,  James Dabrowiak ,  Colleen Alexander

IPC分类号： A61K9/14 ,  A61P35/00 ,  B82B1/00

CPC分类号： A61K31/7042 ,  A61K47/6923 ,  Y10T428/2982

摘要： System and method for loading the front line anticancer drug, doxorubicin (DOX) onto DNA-capped gold nanoparticles whose duplex DNA has been designed for specific DOX intercalation. Since each AuNP contains about 108 high affinity drug sites, this design allows for a high local DOX concentration on the particle. Drug binding was confirmed by monitoring the increase in DNA melting temperature, the shift in the plasmon resonance maximum, and the increase in the NP hydrodynamic radius as a function of [DOX]/[DNA] ratio. The feasibility of the nanoparticles as a drug delivery system was demonstrated by showing that particle-bound DOX could be transferred to a target DNA.

摘要翻译： 将前线抗癌药物多柔比星（DOX）加载到DNA封端的金纳米颗粒上的系统和方法，其双链DNA已被设计用于特定的DOX插层。 由于每个AuNP含有约108个高亲和力的药物部位，因此该设计允许颗粒上的高的局部DOX浓度。 通过监测DNA熔解温度的升高，等离子体共振最大值的移动和作为[DOX] / [DNA]比率的函数的NP流体动力学半径的增加来证实药物结合。 通过显示粒子结合的DOX可以转移到靶DNA来证明纳米颗粒作为药物递送系统的可行性。

公开(公告)号：US08487084B2

公开(公告)日：2013-07-16

申请号：US12418355

申请日：2009-04-03

申请人： Oleg Gang ,  Dmytro Nykypanchuk ,  Mathew Maye ,  Daniel van der Lelie

发明人： Oleg Gang ,  Dmytro Nykypanchuk ,  Mathew Maye ,  Daniel van der Lelie

IPC分类号： C07H21/04

CPC分类号： C07H21/04 ,  C12Q1/6816 ,  C12Q2565/113 ,  C12Q2563/155

摘要： In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying

摘要翻译： 在一些实施方案中，使用DNA封装的纳米粒子来限定其组装中的结晶度。 在一些实施方案中，形成具有占据单元电池的〜10％的颗粒的热力学可逆和稳定的体心立方（bcc）结构。 鉴定了适用于颗粒组件结晶的设计和途径。 在一些实施例中，提供等离子体激元晶体。 在一些方面，提供了一种用于控制颗粒组合的性质的方法。 在一些实施方案中，催化剂由通过核酸序列连接的纳米颗粒形成，并形成具有在其表面或间隙附着于晶体的催化活性剂的开放晶体结构。