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公开(公告)号：US20100125918A1
公开(公告)日：2010-05-20
申请号：US12274194
申请日：2008-11-19
Applicant: Chuan-Mu Chen , Hsiao-Ling Chen
Inventor： Chuan-Mu Chen , Hsiao-Ling Chen
CPC classification number: C07K14/005 , A01K67/0275 , A01K2217/052 , A01K2217/206 , A01K2227/105 , A01K2267/01 , A01K2267/0337 , A61K38/00 , A61K39/00 , A61K2039/542 , C07K2319/02 , C12N15/8509 , C12N2770/32322
Abstract: The invention provides a new type of a capsid protein VP1 of human enterovirus 71, named as MEL701-VP1 and functional/structural variants thereof, which is used for protection against enterovirus. The transgenic animal producing the protein, the composition comprising the protein and the method for production thereof are also provided.
Abstract translation: 本发明提供了一种新型的人肠毒素71的衣壳蛋白VP1，命名为MEL701-VP1及其功能/结构变体，其用于保护免于肠道病毒。 还提供了产生蛋白质的转基因动物，包含蛋白质的组合物及其生产方法。
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公开(公告)号：US07763281B2
公开(公告)日：2010-07-27
申请号：US11856262
申请日：2007-09-17
Applicant: Hsiao-Ling Chen , Chuan-Mu Chen
Inventor： Hsiao-Ling Chen , Chuan-Mu Chen
CPC classification number: C07K14/4732 , A23C9/127 , A23L33/18 , A61K38/00
Abstract: The present invention provides a novel antihypertensive peptide. Also provided are pharmaceutical and food compositions containing the antihypertensive peptide for treating hypertension or cardiovascular disease.
Abstract translation: 本发明提供了一种新的抗高血压肽。 还提供含有用于治疗高血压或心血管疾病的抗高血压肽的药物和食品组合物。
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3.发明授权Transgenic animals producing low-lactose milk and newly identified human small intestinal extracellular lactase-phlorizin hydrolase (ecLPH) gene 有权产生低乳糖乳和新鉴定的人小肠细胞外乳糖酶 - 根皮苷水解酶（ecLPH）基因的转基因动物公开(公告)号：US07501554B2
公开(公告)日：2009-03-10
申请号：US11434332
申请日：2006-05-15
Applicant: Chuan-Mu Chen , Winston T. K. Cheng , Hsiao-Ling Chen
Inventor： Chuan-Mu Chen , Winston T. K. Cheng , Hsiao-Ling Chen
IPC: A01K67/027 , C12N15/00
CPC classification number: C12N9/2405 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/105 , A01K2267/02 , C07K2319/02 , C12N15/8509 , C12N2830/008 , C12Y302/01108
Abstract: The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-phlorizin hydrolase (ecLPH) gene that can express human lactase-hydrolyzing enzyme in the mammary gland of animals. The invention can be used in the production of low-lactose milk.
Abstract translation: 本发明提供一种产生低乳糖的转基因动物，其用编码从人小肠cDNA文库克隆的细胞外乳糖酶水解酶的基因转化。 本发明还提供了可以在动物乳腺中表达人乳糖酶水解酶的新的细胞外乳糖酶 - 根皮苷水解酶（ecLPH）基因。 本发明可用于生产低乳糖乳。
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4.发明申请Newly identified human small intestine extracellular lactase-phlorizin hydrolase (ecLPH) gene 有权新鉴定的人类小肠细胞外乳糖酶 - 根皮苷水解酶（ecLPH）基因公开(公告)号：US20080090279A1
公开(公告)日：2008-04-17
申请号：US11901989
申请日：2007-09-20
Applicant: Chuan-Mu Chen , Winston Cheng , Hsiao-Ling Chen
Inventor： Chuan-Mu Chen , Winston Cheng , Hsiao-Ling Chen
CPC classification number: C12N9/2405 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/105 , A01K2267/02 , C07K2319/02 , C12N15/8509 , C12N2830/008 , C12Y302/01108
Abstract: The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-phlorizin hydrolase (ecLPH) gene that can express human lactase-hydrolyzing enzyme in the mammary gland of animals. The invention can be used in the production of low-lactose milk.
Abstract translation: 本发明提供一种产生低乳糖的转基因动物，其用编码从人小肠cDNA文库克隆的细胞外乳糖酶水解酶的基因转化。 本发明还提供了可以在动物乳腺中表达人乳糖酶水解酶的新的细胞外乳糖酶 - 根皮苷水解酶（ecLPH）基因。 本发明可用于生产低乳糖乳。
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5.发明授权Newly identified human small intestine extracellular lactase-phlorizin hydrolase (ecLPH) gene 有权新鉴定的人类小肠细胞外乳糖酶 - 根皮苷水解酶（ecLPH）基因公开(公告)号：US07795234B2
公开(公告)日：2010-09-14
申请号：US11901989
申请日：2007-09-20
Applicant: Chuan-Mu Chen , Winston T. K. Cheng , Hsiao-Ling Chen
Inventor： Chuan-Mu Chen , Winston T. K. Cheng , Hsiao-Ling Chen
CPC classification number: C12N9/2405 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/105 , A01K2267/02 , C07K2319/02 , C12N15/8509 , C12N2830/008 , C12Y302/01108
Abstract: The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-phlorizin hydrolase (ecLPH) gene that can express human lactase-hydrolyzing enzyme in the mammary gland of animals. The invention can be used in the production of low-lactose milk.
Abstract translation: 本发明提供一种产生低乳糖的转基因动物，其用编码从人小肠cDNA文库克隆的细胞外乳糖酶水解酶的基因转化。 本发明还提供了可以在动物乳腺中表达人乳糖酶水解酶的新的细胞外乳糖酶 - 根皮苷水解酶（ecLPH）基因。 本发明可用于生产低乳糖乳。
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Patent Agency Ranking
公开(公告)号：US20090075896A1
公开(公告)日：2009-03-19
申请号：US11856262
申请日：2007-09-17
Applicant: Hsiao-Ling Chen , Chuan-Mu Chen
Inventor： Hsiao-Ling Chen , Chuan-Mu Chen
CPC classification number: C07K14/4732 , A23C9/127 , A23L33/18 , A61K38/00
Abstract: The present invention provides a novel antihypertensive peptide. Also provided are pharmaceutical and food compositions containing the antihypertensive peptide for treating hypertension or cardiovascular disease.
Abstract translation: 本发明提供了一种新的抗高血压肽。 还提供含有用于治疗高血压或心血管疾病的抗高血压肽的药物和食品组合物。
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7.发明申请Transgenic animals producing low-lactose milk and newly identified human small intestinal extracellular lactase-phlorizin hydrolase (ecLPH) gene 有权产生低乳糖乳和新鉴定的人小肠细胞外乳糖酶 - 根皮苷水解酶（ecLPH）基因的转基因动物公开(公告)号：US20070266451A1
公开(公告)日：2007-11-15
申请号：US11434332
申请日：2006-05-15
Applicant: Chuan-Mu Chen , Winston Cheng , Hsiao-Ling Chen
Inventor： Chuan-Mu Chen , Winston Cheng , Hsiao-Ling Chen
IPC: A01K67/027 , C12N9/24 , C12N15/09
CPC classification number: C12N9/2405 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/105 , A01K2267/02 , C07K2319/02 , C12N15/8509 , C12N2830/008 , C12Y302/01108
Abstract: The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-phlorizin hydrolase (ecLPH) gene that can express human lactase-hydrolyzing enzyme in the mammary gland of animals. The invention can be used in the production of low-lactose milk.
Abstract translation: 本发明提供一种产生低乳糖的转基因动物，其用编码从人小肠cDNA文库克隆的细胞外乳糖酶水解酶的基因转化。 本发明还提供了可以在动物乳腺中表达人乳糖酶水解酶的新的细胞外乳糖酶 - 根皮苷水解酶（ecLPH）基因。 本发明可用于生产低乳糖乳。
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公开(公告)号：US08313750B2
公开(公告)日：2012-11-20
申请号：US13034355
申请日：2011-02-24
Applicant: Chuan-Mu Chen , Hsiao-Ling Chen
Inventor： Chuan-Mu Chen , Hsiao-Ling Chen
CPC classification number: C07K14/005 , A01K67/0275 , A01K2217/052 , A01K2217/206 , A01K2227/105 , A01K2267/01 , A01K2267/0337 , A61K38/00 , A61K39/00 , A61K2039/542 , C07K2319/02 , C12N15/8509 , C12N2770/32322
Abstract: The invention provides a new type of a capsid protein VP1 of human enterovirus 71, named as MEL701-VP1 and functional/structural variants thereof, which is used for protection against enterovirus. The transgenic animal producing the protein, the composition comprising the protein and the method for production thereof are also provided.
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公开(公告)号：US08168192B2
公开(公告)日：2012-05-01
申请号：US12274194
申请日：2008-11-19
Applicant: Chuan-Mu Chen , Hsiao-Ling Chen
Inventor： Chuan-Mu Chen , Hsiao-Ling Chen
CPC classification number: C07K14/005 , A01K67/0275 , A01K2217/052 , A01K2217/206 , A01K2227/105 , A01K2267/01 , A01K2267/0337 , A61K38/00 , A61K39/00 , A61K2039/542 , C07K2319/02 , C12N15/8509 , C12N2770/32322
Abstract: The invention provides a new type of a capsid protein VP1 of human enterovirus 71, named as MEL701-VP1 and functional/structural variants thereof, which is used for protection against enterovirus. The transgenic animal producing the protein, the composition comprising the protein and the method for production thereof are also provided.
Abstract translation: 本发明提供了一种新型的人肠毒素71的衣壳蛋白VP1，命名为MEL701-VP1及其功能/结构变体，其用于保护免于肠道病毒。 还提供了产生蛋白质的转基因动物，包含蛋白质的组合物及其生产方法。
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公开(公告)号：US20140120173A1
公开(公告)日：2014-05-01
申请号：US13661080
申请日：2012-10-26
Applicant: Chuan-Mu Chen , Hsiao-Ling Chen
Inventor： Chuan-Mu Chen , Hsiao-Ling Chen
CPC classification number: C07K2/00 , A23C9/127 , A61K35/20 , A61K38/018
Abstract: The present invention discloses a novel milk-fermented product comprising a group of peptides. The peptides are composed from no. 1 to no. 7 of the figure that is selected from the group consisting of FIG. 11 to FIG. 18. And the novel milk-fermented product is used for suppressing the reduction of bone mineral density. Therefore, the novel milk-fermented product could be a component of foods, nutrient supplement or medicine for treating or preventing osteoporosis.
Abstract translation: 本发明公开了一种包含一组肽的新型乳发酵产品。 肽由no组成。 1到否 该图中的图7选自图1所示的组。 图11〜 而新型乳发酵产品用于抑制骨矿物质密度的降低。 因此，新型乳发酵产品可以作为食品，营养补充剂或治疗或预防骨质疏松症的药物的成分。
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