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公开(公告)号：US08535915B2
公开(公告)日：2013-09-17
申请号：US12864979
申请日：2009-01-23
申请人： Chul Ha Kim , Jong Soo Choi , Sang Jo Lim , Hyung Joon Kim , So Yeon Rah , Gey Hang Jeon
发明人： Chul Ha Kim , Jong Soo Choi , Sang Jo Lim , Hyung Joon Kim , So Yeon Rah , Gey Hang Jeon
摘要： Disclosed are a nucleic acid molecule of Corynebacterium glutamicum origin, having an improved promoter activity, which is operably linked to a gene encoding diaminopimelate dehydrogenase, a vector containing the same, a transformant transformed with the vector, and a method for the production of L-lysine using the transformant.
摘要翻译： 公开了具有改善的启动子活性的谷氨酸棒杆菌起源的核酸分子，其与编码二氨基庚二酸脱氢酶的基因，含有其的载体，用该载体转化的转化体可操作地连接， 赖氨酸使用转化体。
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公开(公告)号：US20110076731A1
公开(公告)日：2011-03-31
申请号：US12864979
申请日：2009-01-23
申请人： Chul Ha KIM , Jong Soo Choi , Sang Jo Lim , Hyung Joon Kim , So Yeon Rah , Gey Hang Jeon
发明人： Chul Ha KIM , Jong Soo Choi , Sang Jo Lim , Hyung Joon Kim , So Yeon Rah , Gey Hang Jeon
摘要： Disclosed are a nucleic acid molecule of Corynebacterium glutamicum origin, having an improved promoter activity, which is operably linked to a gene encoding diaminopimelate dehydrogenase, a vector containing the same, a transformant transformed with the vector, and a method for the production of L-lysine using the transformant.
摘要翻译： 公开了具有改善的启动子活性的谷氨酸棒杆菌起源的核酸分子，其与编码二氨基庚二酸脱氢酶的基因，含有其的载体，用该载体转化的转化体可操作地连接， 赖氨酸使用转化体。
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公开(公告)号：US20100317067A1
公开(公告)日：2010-12-16
申请号：US12864731
申请日：2009-01-23
申请人： Chul Ha Kim , Jong Soo Choi , Sang Jo Lim , Hyung Joon Kim , Jun Ok Moon , Gey Hang Jeon , Jin Suk Sung
发明人： Chul Ha Kim , Jong Soo Choi , Sang Jo Lim , Hyung Joon Kim , Jun Ok Moon , Gey Hang Jeon , Jin Suk Sung
CPC分类号： C12P13/08 , C12N9/0008 , C12N9/1217
摘要： Disclosed are a nucleic acid molecule of Corynebacterium glutamicum origin, having an improved promoter activity, which is operably linked to operon encoding aspartate kinase and aspartate semialdehyde dehydrogense, a vector containing the same, a transformant transformed with the vector, and a method for the production of L-lysine using the transformant.
摘要翻译： 公开了具有改良的启动子活性的谷氨酸棒杆菌起源的核酸分子，其可操作地连接到编码天冬氨酸激酶和天冬氨酸半醛脱氢酶的操纵子，含有它的载体，用载体转化的转化体，以及生产方法 的L-赖氨酸。
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公开(公告)号：US08426577B2
公开(公告)日：2013-04-23
申请号：US12864731
申请日：2009-01-23
申请人： Chul Ha Kim , Jong Soo Choi , Sang Jo Lim , Hyung Joon Kim , Jun Ok Moon , Gey Hang Jeon , Jin Suk Sung
发明人： Chul Ha Kim , Jong Soo Choi , Sang Jo Lim , Hyung Joon Kim , Jun Ok Moon , Gey Hang Jeon , Jin Suk Sung
CPC分类号： C12P13/08 , C12N9/0008 , C12N9/1217
摘要： Disclosed are a nucleic acid molecule of Corynebacterium glutamicum origin, having an improved promoter activity, which is operably linked to operon encoding aspartate kinase and aspartate semialdehyde dehydrogense, a vector containing the same, a transformant transformed with the vector, and a method for the production of L-lysine using the transformant.
摘要翻译： 公开了具有改良的启动子活性的谷氨酸棒杆菌起源的核酸分子，其可操作地连接到编码天冬氨酸激酶和天冬氨酸半醛脱氢酶的操纵子，含有它的载体，用载体转化的转化体，以及生产方法 的L-赖氨酸。
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5.发明申请CORYNEBACTERIA HAVING ENHANCED L-LYSINE PRODUCTIVITY AND A METHOD OF PRODUCING L-LYSINE USING THE SAME 有权具有增强的L-赖氨酸生产力的罗非鱼和使用该L-赖氨酸生产L-赖氨酸的方法公开(公告)号：US20100143984A1
公开(公告)日：2010-06-10
申请号：US12441358
申请日：2007-09-17
申请人： Young Hoon Park , Sang Jo Lim , Jun Ok Moon , So Yeon Rah , Hee Jong Lee , Jae Woo Jang , Do Hyun Kwon , Hyo Jin Kim , Jin Suck Sung , Hyung Joon Kim
发明人： Young Hoon Park , Sang Jo Lim , Jun Ok Moon , So Yeon Rah , Hee Jong Lee , Jae Woo Jang , Do Hyun Kwon , Hyo Jin Kim , Jin Suck Sung , Hyung Joon Kim
CPC分类号： C12P13/08 , C12N9/001 , C12N9/1096 , C12N9/1217 , C12N9/88
摘要： A variant of Corynebacterium shows activity greater than the endogenous activity of aspartate aminotransferase, aspartate kinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydropicolinate reductase and diaminopimelate dicarboxylase and additionally pyruvate carboxylase. The variant is used in a method of producing L-lysine.
摘要翻译： 棒状杆菌的变体显示出比天冬氨酸氨基转移酶，天冬氨酸激酶，天冬氨酸半醛脱氢酶，二氢吡啶二羧酸合酶，二氢吡啶甲酸酯还原酶和二氨基庚二酸二羧酸酶以及另外的丙酮酸羧化酶的内源性活性更大的活性。 该变体用于生产L-赖氨酸的方法。
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6.发明授权Corynebacteria having enhanced L-lysine productivity and a method of producing L-lysine using the same 有权具有增强的L-赖氨酸生产力的棒状杆菌和使用其产生L-赖氨酸的方法公开(公告)号：US09109242B2
公开(公告)日：2015-08-18
申请号：US12441358
申请日：2007-09-17
申请人： Young Hoon Park , Sang Jo Lim , Jun Ok Moon , So Yeon Rah , Hee Jong Lee , Jae Woo Jang , Do Hyun Kwon , Hyo Jin Kim , Jin Suck Sung , Hyung Joon Kim
发明人： Young Hoon Park , Sang Jo Lim , Jun Ok Moon , So Yeon Rah , Hee Jong Lee , Jae Woo Jang , Do Hyun Kwon , Hyo Jin Kim , Jin Suck Sung , Hyung Joon Kim
CPC分类号： C12P13/08 , C12N9/001 , C12N9/1096 , C12N9/1217 , C12N9/88
摘要： A variant of Corynebacterium shows activity greater than the endogenous activity of aspartate aminotransferase, aspartate kinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydropicolinate reductase and diaminopimelate dicarboxylase and additionally pyruvate carboxylase. The variant is used in a method of producing L-lysine.
摘要翻译： 棒状杆菌的变体显示出比天冬氨酸氨基转移酶，天冬氨酸激酶，天冬氨酸半醛脱氢酶，二氢吡啶二羧酸合酶，二氢吡啶甲酸酯还原酶和二氨基庚二酸二羧酸酶以及另外的丙酮酸羧化酶的内源性活性更大的活性。 该变体用于生产L-赖氨酸的方法。
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7.发明授权Microorganism of corynebacterium genus having enhanced L-lysine production ability and method of producing L-lysine using the same 有权具有增强的L-赖氨酸生产能力的棒状杆菌属的微生物和使用其产生L-赖氨酸的方法公开(公告)号：US07794990B2
公开(公告)日：2010-09-14
申请号：US11564599
申请日：2006-11-29
申请人： Young Hoon Park , Hyun Min Koo , Sang Jo Lim , Jun Ok Moon , So Yeon Rah , Young Lyeol Yang
发明人： Young Hoon Park , Hyun Min Koo , Sang Jo Lim , Jun Ok Moon , So Yeon Rah , Young Lyeol Yang
CPC分类号： C12R1/15 , C12N9/1205 , C12N9/88 , C12P13/08
摘要： Provided are a microorganism of Corynebacterium genus that has an inactivated endogenous NCgl1835 gene therein and produces L-lysine, and a method of producing L-lysine using the same.
摘要翻译： 本发明提供一种具有失活的内源性NCgl1835基因并产生L-赖氨酸的棒状杆菌属的微生物，以及使用该微生物的L-赖氨酸的方法。
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8.发明申请METHOD FOR PRODUCING L-LYSINE USING CORYNEBACTERIUM SP. THAT HAS OBTAINED THE ACTIVITY OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE DERIVED FROM AN ALIEN SPECIES 审中-公开使用椰子油生产L-赖氨酸的方法 已经获得了从其他物种衍生的甘油三磷酸脱氢酶的活性公开(公告)号：US20120208245A1
公开(公告)日：2012-08-16
申请号：US13382899
申请日：2010-05-28
申请人： So Yeon Rah , Sang Jo Lim
发明人： So Yeon Rah , Sang Jo Lim
摘要： The present invention relates to a Corynebacterium sp. strain having an activity of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase and an improved productivity of L-lysine, and a method for producing L-lysine using the same. According to the Corynebacterium sp. strain of the present invention and the method for producing L-lysine using the same, L-lysine can be produced in a high yield.
摘要翻译： 本发明涉及棒杆菌属（Corynebacterium sp。） 具有NADP依赖性甘油醛-3-磷酸脱氢酶的活性和提高的L-赖氨酸的生产率的菌株，以及使用其生产L-赖氨酸的方法。 根据棒杆菌属 本发明的菌株和使用其的L-赖氨酸的制造方法可以高产率制备L-赖氨酸。
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9.发明申请CORYNEBACTERIUM SP. TRANSFORMED WITH A FRUCTOKINASE GENE DERIVED FROM ESCHERICHIA SP. AND PROCESS FOR PREPARING L-AMINO ACID USING THE SAME 有权红霉素 用来自ESCHERICHIA SP的FRUCTOKINASE基因转化。 和使用该方法制备L-氨基酸的方法和方法公开(公告)号：US20140099680A1
公开(公告)日：2014-04-10
申请号：US14007941
申请日：2012-04-02
申请人： Hyun Won Bae , Hyung Joon Kim , Jun Ok Moon , Jae Woo Jang , Jong Chul Kim , Tae Han Kim , Jin Suck Sung , Kyung Han Lee , Dae Cheol Kim , Hyo Jin Kim , Hyun Ae Bae , Sang Jo Lim
发明人： Hyun Won Bae , Hyung Joon Kim , Jun Ok Moon , Jae Woo Jang , Jong Chul Kim , Tae Han Kim , Jin Suck Sung , Kyung Han Lee , Dae Cheol Kim , Hyo Jin Kim , Hyun Ae Bae , Sang Jo Lim
CPC分类号： C12P13/14 , C12N9/1205 , C12P13/04 , C12P13/08 , C12Y207/01004
摘要： The present invention relates to Corynebacterium sp. that is transformed with an Escherichia sp.-derived fructokinase gene to express fructokinase showing a sufficient activity of converting fructose into fructose-6-phosphate, thereby preventing unnecessary energy consumption, and a method for producing L-amino acids using the strain. The transformed Corynebacterium sp. of the present invention is able to express fructokinase from the Escherichia-derived fructokinase gene to prevent unnecessary energy consumption during fructose metabolism, leading to more cost-effective production of L-amino acids. Therefore, it can be widely used for the effective production of L-amino acids.
摘要翻译： 本发明涉及棒状杆菌属 用Escherichia sp.衍生的果糖激酶基因转化以表达果糖激酶，其显示出将果糖转化为果糖-6-磷酸的足够活性，从而防止不必要的能量消耗，以及使用该菌株产生L-氨基酸的方法。 转化的棒状杆菌属 本发明能够从来自大肠杆菌的果糖激酶基因中表达果糖激酶，以防止在果糖代谢期间不必要的能量消耗，导致L-氨基酸的更具成本效益的生产。 因此，可广泛用于L-氨基酸的有效生产。
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10.发明申请Microorganism with Enhanced L-Lysine Productivity and Method for Producing L-Lysine Using the Same 审中-公开具有增强的L-赖氨酸生产力的微生物和使用其生产L-赖氨酸的方法公开(公告)号：US20130102037A1
公开(公告)日：2013-04-25
申请号：US13378145
申请日：2011-07-15
申请人： Sang Jo Lim , Jun Ok Moon , Hyung Joon Kim , Jae Woo Jang , Jae Yong Cho
发明人： Sang Jo Lim , Jun Ok Moon , Hyung Joon Kim , Jae Woo Jang , Jae Yong Cho
IPC分类号： C12N15/77
CPC分类号： C12N15/77 , C12N9/1205 , C12P13/08
摘要： Disclosed is an L-lysine-producing microorganism having gluconate kinase activity weakened in comparison to the endogenous activity thereof, and methods provided for preparing the microorganism and for producing L-lysine using the same.
摘要翻译： 公开了与其内源活性相比，具有葡萄糖酸激酶活性弱的L-赖氨酸生产微生物，以及提供用于制备微生物和使用该微生物生产L-赖氨酸的方法。
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