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    Use of Tyrphostins to Stimulate Neurite Outgrowth
    1.
    发明申请
    Use of Tyrphostins to Stimulate Neurite Outgrowth 审中-公开
    使用酪氨酸激酶刺激神经突生长

    公开(公告)号：US20090012179A1

    公开(公告)日：2009-01-08

    申请号：US11658618

    申请日：2005-08-04

    申请人： Chunhe Wang ,  Bruce G. Gold ,  Kim A. Neve ,  Yong-Ping Zhong ,  Xiaolin Yu ,  Robert A. Johnson

    发明人： Chunhe Wang ,  Bruce G. Gold ,  Kim A. Neve ,  Yong-Ping Zhong ,  Xiaolin Yu ,  Robert A. Johnson

    IPC分类号： A61K31/05 ,  C12N5/06 ,  A61P25/00

    CPC分类号： A61K31/275

    摘要： Disclosed herein are several methods for promoting nerve regeneration. The methods include administering at least one tyrphostin, or a pharmaceutically acceptable salt thereof. In one non-limiting example, the tyrphostin is tyrphostin A9. These methods can be used to promote nerve growth in the central or peripheral nervous system. The methods are of use in treating neurodegenerative diseases, such as Parkinson's disease, or in treating the transaction of a partial or complete transaction of a nerve in the peripheral or central nervous system.

    摘要翻译： 本文公开了促进神经再生的几种方法。 所述方法包括施用至少一种酪氨酸磷酸酯或其药学上可接受的盐。 在一个非限制性实例中，酪氨酸磷酸酶是酪氨酸磷酸酶A9。 这些方法可用于促进中枢或周围神经系统的神经生长。 该方法可用于治疗神经变性疾病，例如帕金森病，或用于治疗外周或中枢神经系统中部分或完全交感神经的交易。

    METHODS AND COMPOSITIONS FOR NERVE REGENERATION
    2.
    发明申请
    METHODS AND COMPOSITIONS FOR NERVE REGENERATION 审中-公开
    神经再生的方法和组合

    公开(公告)号：US20100303934A1

    公开(公告)日：2010-12-02

    申请号：US12793478

    申请日：2010-06-03

    申请人： Amala Soumyanath ,  Bruce G. Gold ,  Sandra Gold ,  Yong-Ping Zhong ,  Dennis Bourdette

    发明人： Amala Soumyanath ,  Bruce G. Gold ,  Sandra Gold ,  Yong-Ping Zhong ,  Dennis Bourdette

    IPC分类号： A61K36/00 ,  A61K31/704 ,  A61K31/19 ,  A61P25/00

    CPC分类号： A61K36/23

    摘要： A method of promoting nerve regeneration in a subject that includes administering to the subject a therapeutically effective amount of a composition that includes at least one therapeutically-active extract fraction of Centella asiatica. One example of making the extract fraction of Centella asiatica involves extracting Centella asiatica plant material resulting in an extract residue and successively fractionating the Centella asiatica extract residue with at least two eluants of increasing polarity.

    摘要翻译： 一种在受试者中促进神经再生的方法，其包括向受试者施用治疗有效量的包含积雪草积分的至少一种治疗活性提取物部分的组合物。 制备积雪草提取物部分的一个实例涉及提取积雪草植物材料，从而产生提取物残余物，并用至少两种增加极性的洗脱液连续分离积雪草提取物残留物。

    Compositions and methods for promoting nerve regeneration
    4.
    发明授权
    Compositions and methods for promoting nerve regeneration 失效
    促进神经再生的组合物和方法

    公开(公告)号：US06210974B1

    公开(公告)日：2001-04-03

    申请号：US09288061

    申请日：1999-04-07

    申请人： Bruce G. Gold

    发明人： Bruce G. Gold

    IPC分类号： G01N33566

    CPC分类号： A61K31/4745 ,  A61K31/395 ,  A61K38/1883 ,  A61K45/06 ,  G01N33/5058 ,  G01N33/743 ,  G01N2500/02 ,  Y10T436/14 ,  A61K2300/00

    摘要： FK506 and geldanamycin promote nerve regeneration by a common mechanism that involves the binding of these compounds to polypeptide components of steroid receptor complexes other than the steroid hormone binding portion of the complex (FKBP52 and hsp90, respectively). These and other agents cause hsp90 dissociation from steroid receptor complexes or block association of hsp90 with steroid receptor complexes.

    摘要翻译： FK506和格尔德霉素通过一种共同的机制促进神经再生，这种机制涉及这些化合物与复合物类固醇激素结合部分以外的类固醇受体复合物的多肽组分的结合（分别为FKBP52和hsp90）。 这些和其他药物导致hsp90从类固醇受体复合物解离或阻断hsp90与类固醇受体复合物的结合。

    Methods of screening for agents that promote nerve cell growth
    5.
    发明授权
    Methods of screening for agents that promote nerve cell growth 失效
    筛选促进神经细胞生长的药物的方法

    公开(公告)号：US06852496B1

    公开(公告)日：2005-02-08

    申请号：US09130887

    申请日：1998-08-07

    申请人： Bruce G. Gold

    发明人： Bruce G. Gold

    IPC分类号： A61K49/00 ,  G01N33/566 ,  G01N33/53 ,  A01N43/40

    CPC分类号： A61K49/0008 ,  G01N33/566 ,  G01N2500/00

    摘要： Analogs of FK506 that do not bind FKBP-12 have been found to effectively promote nerve cell growth and regeneration, thereby speeding functional recovery of damaged nervous tissue and axonal regeneration without causing immunosuppression.

    摘要翻译： 已经发现不结合FKBP-12的FK506的类似物有效地促进神经细胞生长和再生，从而加速损伤的神经组织和轴突再生的功能恢复，而不引起免疫抑制。

    Methods of using geldanamycin and FK506 to treat peripheral nerve damage
    6.
    发明授权
    Methods of using geldanamycin and FK506 to treat peripheral nerve damage 失效
    使用格尔德霉素和FK506治疗周围神经损伤的方法

    公开(公告)号：US06641810B2

    公开(公告)日：2003-11-04

    申请号：US09825243

    申请日：2001-04-02

    申请人： Bruce G. Gold

    发明人： Bruce G. Gold

    IPC分类号： A61K39395

    CPC分类号： A61K31/4745 ,  A61K31/395 ,  A61K38/1883 ,  A61K45/06 ,  G01N33/5058 ,  G01N33/743 ,  G01N2500/02 ,  Y10T436/14 ,  A61K2300/00

    摘要： FK506 and geldanamycin promote nerve regeneration by a common mechanism that involves the binding of these compounds to polypeptide components of steroid receptor complexes other than the steroid hormone binding portion of the complex (FKBPS52 and hsp90, respectively). These and other agents cause hsp90 dissociation from steroid receptor complexes or block association of hsp90 with steroid receptor complexes.

    摘要翻译： FK506和格尔德霉素通过常规机制促进神经再生，其包括将这些化合物与复合物的类固醇激素结合部分以外的类固醇受体复合物的多肽成分结合（分别为FKBPS52和hsp90）。 这些和其他药物导致hsp90从类固醇受体复合物解离或阻断hsp90与类固醇受体复合物的结合。

    Methods for identifying an analog that promotes nerve regeneration
    7.
    发明授权
    Methods for identifying an analog that promotes nerve regeneration 失效
    识别促进神经再生的类似物的方法

    公开(公告)号：US07282340B2

    公开(公告)日：2007-10-16

    申请号：US10943506

    申请日：2004-09-17

    申请人： Bruce G. Gold

    发明人： Bruce G. Gold

    IPC分类号： G01N33/53 ,  A61K31/44

    CPC分类号： A61K49/0008 ,  G01N33/566 ,  G01N2500/00

    摘要： Analogs of FK506 that do not bind FKBP-12 have been found to effectively promote nerve cell growth and regeneration, thereby speeding functional recovery of damaged nervous tissue and axonal regeneration without causing immunosuppression.

    摘要翻译： 已经发现不结合FKBP-12的FK506的类似物有效地促进神经细胞生长和再生，从而加速损伤的神经组织和轴突再生的功能恢复，而不引起免疫抑制。

    Compositions and methods for promoting nerve regeneration
    8.
    发明授权
    Compositions and methods for promoting nerve regeneration 失效
    促进神经再生的组合物和方法

    公开(公告)号：US06734211B1

    公开(公告)日：2004-05-11

    申请号：US10030904

    申请日：2002-04-29

    申请人： Bruce G. Gold

    发明人： Bruce G. Gold

    IPC分类号： A61K3121

    CPC分类号： C12Q1/48 ,  A61F7/00 ,  A61K31/00 ,  A61K31/165 ,  A61K31/21 ,  A61K31/365 ,  A61K31/395 ,  A61K31/436 ,  A61K31/444 ,  A61K38/185 ,  G01N2500/00

    摘要： Neurite outgrowth and nerve regeneration are promoted by disruption of the steroid receptor complex and stimulation of MAP kinase/kinase activity. This disruption can take the form of disruption of the physical assembly or function of the steroid receptor complex, such as the mature complex or a precursor of the mature complex that is required for assembly of the mature complex. Geldanamycin and its analogs, bastadin and members of the bastadin family, and radicicol and its analogs, as well as FKBP-52 antibody, are shown to disrupt the complex and promote nerve growth. Assays for finding neurotrophic compounds, as well as compounds found by these assays, pharmaceutical compositions into which they are incorporated, and methods of treating subjects having neuronal dysfunction caused by injury or disease are disclosed. Any of these compounds can be used in combination with a therapeutically effective amount of heat, such as heat applied locally to an area where nerve growth is desired, or systemically in an organism in which neurite growth is desired. Alternatively, these compounds can be used in association with a template, such as a tubular member that defines an anatomic pathway along which nerve regeneration is desired (particularly around a transected or partially transected nerve).

    摘要翻译： 通过破坏类固醇受体复合物和MAP激酶/激酶活性的刺激来促进神经突生长和神经再生。 这种破坏可以采取类固醇受体复合物的物理组装或功能的破坏的形式，例如成熟复合物或成熟复合物组装所需的成熟复合物的前体。 格尔德霉素及其类似物，bastadin和bastadin家族的成员以及radicicol及其类似物以及FKBP-52抗体显示破坏复合物并促进神经生长。 公开了用于发现神经营养化合物的测定法，以及通过这些测定法发现的化合物，其并入其中的药物组合物，以及治疗由损伤或疾病引起的神经元功能障碍的受试者的方法。 这些化合物中的任何一种可以与治疗有效量的热量组合使用，例如局部施用于需要神经生长的区域的热量，或者在需要神经突生长的生物体中全身地使用。 或者，这些化合物可以与模板结合使用，例如限定需要神经再生的解剖学途径的管状构件（特别是在横切或部分横切的神经周围）。