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公开(公告)号：US20110008345A1
公开(公告)日：2011-01-13
申请号：US12744799
申请日：2008-11-28
申请人： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
发明人： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N5/10 , C12P21/04 , A61P35/00 , A61P11/06 , A61P19/02
CPC分类号： C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US20090148905A1
公开(公告)日：2009-06-11
申请号：US12324905
申请日：2008-11-28
申请人： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
发明人： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC分类号： C12P21/02 , C07K16/00 , C07H21/00 , A61K39/395 , C12N5/10
CPC分类号： C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US09109031B2
公开(公告)日：2015-08-18
申请号：US13387376
申请日：2010-07-27
IPC分类号： C07K16/28 , A61K39/395 , C12N15/13 , C12N15/63 , C07K16/40
CPC分类号： C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis, liver fibrosis, including cirrhosis and chronic hepatitis, rheumatoid arthritis, ocular disorders, or fibrosis of the skin, including keloid of skin, and kidney such as nephritis, kidney fibrosis and nephrosclerosis, and a vascular condition, such as restenosis.
摘要翻译： 本公开提供了抗TGFbetaRII免疫球蛋白单可变结构域。 本公开还提供了用于治疗与TGFbeta信号传导相关疾病和选自以下组的疾病的多肽，配体或药物组合物：组织纤维化，例如肺纤维化，包括特发性肺纤维化，肝纤维化，包括肝硬化和慢性肝炎， 类风湿性关节炎，眼部疾病或皮肤纤维化，包括皮肤瘢痕疙瘩，肾脏如肾炎，肾纤维化和肾硬化，以及血管病变，如再狭窄。
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公开(公告)号：US20140341971A1
公开(公告)日：2014-11-20
申请号：US14159791
申请日：2014-06-20
IPC分类号： A61K39/395 , A61K39/00 , A61K38/21
CPC分类号： A61K39/3955 , A61K38/217 , A61K39/0011 , A61K2039/55516 , A61K2039/55555 , A61K2039/6018 , C07K14/4748 , C07K16/2851 , C07K2317/22 , C07K2317/569
摘要： The present invention relates to a composition for targeting dendritic cells. In particular, the present invention relates to a composition comprising: a) one or more antigens; b) an anti-DC-SIGN immunoglobulin single variable domain; and c) a carrier which carries a) and b). The invention further relates to formulations, compositions and devices comprising such anti-DC-SIGN molecules and their use as a medicament and in the treatment of cancer, suitably melanoma.
摘要翻译： 本发明涉及用于靶向树突状细胞的组合物。 特别地，本发明涉及一种组合物，其包含：a）一种或多种抗原; b）抗DC-SIGN免疫球蛋白单可变区; 和c）承载a）和b）的载体。 本发明还涉及包含这种抗DC-SIGN分子的制剂，组合物和装置及其作为药物的用途，以及用于治疗癌症，适当地为黑素瘤。
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公开(公告)号：US20120129778A1
公开(公告)日：2012-05-24
申请号：US13387376
申请日：2010-07-27
IPC分类号： A61K38/16 , C07K19/00 , C12N15/11 , C12N15/63 , C12P21/02 , C12N5/10 , A61P19/02 , A61P13/12 , A61P17/00 , C12N1/21 , C12N1/19 , C12N1/15 , C07K14/00 , A61P1/16
CPC分类号： C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis, liver fibrosis, including cirrhosis and chronic hepatitis, rheumatoid arthritis, ocular disorders, or fibrosis of the skin, including keloid of skin, and kidney such as nephritis, kidney fibrosis and nephrosclerosis, and a vascular condition, such as restenosis.
摘要翻译： 本公开提供了抗TGFbetaRII免疫球蛋白单可变结构域。 本公开还提供了用于治疗与TGFbeta信号传导相关疾病和选自以下组的疾病的多肽，配体或药物组合物：组织纤维化，例如肺纤维化，包括特发性肺纤维化，肝纤维化，包括肝硬化和慢性肝炎， 类风湿性关节炎，眼部疾病或皮肤纤维化，包括皮肤瘢痕疙瘩，肾脏如肾炎，肾纤维化和肾硬化，以及血管病变，如再狭窄。
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公开(公告)号：US20110212168A1
公开(公告)日：2011-09-01
申请号：US13125332
申请日：2009-10-19
IPC分类号： A61K9/127 , A61K39/395 , A61K38/21 , A61P35/00
CPC分类号： A61K39/3955 , A61K38/217 , A61K39/0011 , A61K2039/55516 , A61K2039/55555 , A61K2039/6018 , C07K14/4748 , C07K16/2851 , C07K2317/22 , C07K2317/569
摘要： The present disclosure relates to a composition for targeting dendritic cells. In particular, the present disclosure relates to a composition comprising: a) one or more antigens; b) an anti-DC-SIGN immunoglobulin single variable domain; and c) a carrier which carries a) and b). The disclosure further relates to formulations, compositions and devices comprising such anti-DC-SIGN molecules and their use as a medicament and in the treatment of cancer, suitably melanoma.
摘要翻译： 本公开涉及用于靶向树突状细胞的组合物。 特别地，本公开涉及一种组合物，其包含：a）一种或多种抗原; b）抗DC-SIGN免疫球蛋白单可变区; 和c）承载a）和b）的载体。 本公开还涉及包含这种抗DC-SIGN分子的制剂，组合物和装置及其作为药物的用途，以及用于治疗癌症，适当地为黑素瘤。
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公开(公告)号：US08779107B2
公开(公告)日：2014-07-15
申请号：US13125332
申请日：2009-10-19
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K9/127
CPC分类号： A61K39/3955 , A61K38/217 , A61K39/0011 , A61K2039/55516 , A61K2039/55555 , A61K2039/6018 , C07K14/4748 , C07K16/2851 , C07K2317/22 , C07K2317/569
摘要： The present disclosure relates to a composition for targeting dendritic cells. In particular, the present disclosure relates to a composition comprising: a) one or more antigens; b) an anti-DC-SIGN immunoglobulin single variable domain; and c) a carrier which carries a) and b). The disclosure further relates to formulations, compositions and devices comprising such anti-DC-SIGN molecules and their use as a medicament and in the treatment of cancer, suitably melanoma.
摘要翻译： 本公开涉及用于靶向树突状细胞的组合物。 特别地，本公开涉及一种组合物，其包含：a）一种或多种抗原; b）抗DC-SIGN免疫球蛋白单可变区; 和c）承载a）和b）的载体。 本公开还涉及包含这种抗DC-SIGN分子的制剂，组合物和装置及其作为药物的用途，以及用于治疗癌症，适当地为黑素瘤。
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公开(公告)号：US20130045895A1
公开(公告)日：2013-02-21
申请号：US13642200
申请日：2011-04-19
CPC分类号： C07K16/00 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/3007 , C07K2317/567 , C07K2317/569 , C07K2317/92
摘要： The invention relates to amino acid residues within an immunoglobulin light chain amino acid sequence (VL) which stabilize the monomeric state of the immunoglobulin single variable domain. In particular, but not exclusively, the invention describes a number of mutations that stabilize the monomeric state of DPK9 framework Vκ domain antibodies.
摘要翻译： 本发明涉及稳定免疫球蛋白单可变结构域的单体状态的免疫球蛋白轻链氨基酸序列（VL）内的氨基酸残基。 具体而非排他地，本发明描述了许多稳定DPK9构架V＆kgr的单体状态的突变; 结构域抗体。
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公开(公告)号：US20110257373A1
公开(公告)日：2011-10-20
申请号：US13125384
申请日：2009-10-19
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/569
摘要： The present invention disclosure provides an anti-dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN; CD209) immunoglobulin single variable domain. Polypeptides, ligands and compositions comprising such anti-DC-SIGN immunoglobulin single variable domains are also described along with nucleic acids encoding such immunoglobulins and vectors and host cells for expression. The invention disclosure further relates to uses, formulations, compositions and devices comprising such DC-SIGN-binding agents.
摘要翻译： 本发明公开内容提供抗树突状细胞特异性ICAM-3抓取非整联蛋白（DC-SIGN; CD209）免疫球蛋白单可变结构域。 还描述了包含这种抗DC-SIGN免疫球蛋白单可变结构域的多肽，配体和组合以及编码这种免疫球蛋白的核酸和用于表达的载体和宿主细胞。 本发明进一步涉及包含这种DC-SIGN结合剂的用途，制剂，组合物和装置。
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