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    Mutant CyaA Polypeptides and Polypeptide Derivatives Suitable for the Delivery of Immunogenic Molecules Into a Cell
    9.
    发明申请
    Mutant CyaA Polypeptides and Polypeptide Derivatives Suitable for the Delivery of Immunogenic Molecules Into a Cell 有权
    突变型CyaA多肽和多肽衍生物适合于将免疫原性分子递送到细胞中

    公开(公告)号：US20120071393A1

    公开(公告)日：2012-03-22

    申请号：US13257569

    申请日：2010-03-23

    申请人： Peter Sebo ,  Adriana Osickova ,  Jiri Masin ,  Catherine Fayolle ,  Jan Krusek ,  Merek Basler ,  Claude Leclerc ,  Radim Osicka

    发明人： Peter Sebo ,  Adriana Osickova ,  Jiri Masin ,  Catherine Fayolle ,  Jan Krusek ,  Merek Basler ,  Claude Leclerc ,  Radim Osicka

    IPC分类号： A61K38/00 ,  A61P31/12 ,  A61P31/14 ,  C07K14/235 ,  A61P35/00

    CPC分类号： C12N9/88 ,  C12Y406/01001

    摘要： The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host.The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.

    摘要翻译： 本发明涉及适用于蛋白质载体的突变型CyaA / E570Q + K860多肽，用于将一种或多种感兴趣的分子递送至细胞，特别是表达CD11b受体的细胞中。 本发明还涉及适于在宿主中引发免疫应答的多肽衍生物。 本发明更具体涉及衍生自作为突变体多肽的毒素或类毒素形式的腺苷酸环化酶蛋白（CyaA）的多肽。 所述突变体多肽能够将天然CyaA的结合活性保留到靶细胞，并且优选还将天然CyaA的易位活性通过其N-末端结构域保留到靶细胞中，并且还具有减少或抑制的造孔活性 与天然CyaA毒素相比。

    Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell
    10.
    发明授权
    Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell 有权
    突变型CyaA多肽和多肽衍生物，适于将免疫原性分子递送至细胞中

    公开(公告)号：US08017132B2

    公开(公告)日：2011-09-13

    申请号：US12409324

    申请日：2009-03-23

    申请人： Peter Sebo ,  Claude Leclerc ,  Adriana Osickova ,  Catherine Fayolle ,  Jiri Masin ,  Jan Krusek ,  Radim Osicka ,  Marek Basler

    发明人： Peter Sebo ,  Claude Leclerc ,  Adriana Osickova ,  Catherine Fayolle ,  Jiri Masin ,  Jan Krusek ,  Radim Osicka ,  Marek Basler

    IPC分类号： A61K39/10

    CPC分类号： C12N9/88 ,  A61K38/00

    摘要： The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host.The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.

    摘要翻译： 本发明涉及适用于蛋白质载体的突变型CyaA / E570Q + K860多肽，用于将一种或多种感兴趣的分子递送至细胞，特别是表达CD11b受体的细胞中。 本发明还涉及适于在宿主中引发免疫应答的多肽衍生物。 本发明更具体涉及衍生自作为突变体多肽的毒素或类毒素形式的腺苷酸环化酶蛋白（CyaA）的多肽。 所述突变体多肽能够将天然CyaA的结合活性保留到靶细胞，并且优选还将天然CyaA的易位活性通过其N-末端结构域保留到靶细胞中，并且还具有减少或抑制的造孔活性 与天然CyaA毒素相比。