公开(公告)号：US20090112307A1

公开(公告)日：2009-04-30

申请号：US12255852

申请日：2008-10-22

申请人： Claus Harder ,  Alexander Borck ,  Gerd Bayer ,  Matthias Fringes

发明人： Claus Harder ,  Alexander Borck ,  Gerd Bayer ,  Matthias Fringes

IPC分类号： A61F2/44

CPC分类号： A61L31/16 ,  A61F2/0077 ,  A61F2/86 ,  A61F2250/0068 ,  A61L31/022 ,  A61L31/088 ,  A61L2300/25 ,  A61L2300/256 ,  A61L2300/416

摘要： A stent having a base body of a bioinert metallic implant material wherein the base body is covered with an SiC coating. An external surface of the base body has a plurality of cavities which are filled with an antiproliferative active ingredient, A luminal surface of the base body has a coating which contains or comprises attractors for endothelial cells.

摘要翻译： 一种具有生物惰性金属植入材料的基体的支架，其中所述基体被SiC涂层覆盖。 基体的外表面具有填充有抗增殖活性成分的多个空腔。基体的管腔表面具有包含或包含内皮细胞吸引子的涂层。

公开(公告)号：US20080234790A1

公开(公告)日：2008-09-25

申请号：US10562095

申请日：2004-05-21

申请人： Gerd Bayer ,  Alexander Borck

发明人： Gerd Bayer ,  Alexander Borck

IPC分类号： A61N1/05

CPC分类号： C08L5/08 ,  A61K47/6957 ,  A61L31/10 ,  A61L31/148 ,  A61N1/0565 ,  A61N1/0568 ,  C08B37/0072 ,  C09D105/08 ,  C08L2666/26

摘要： An implantable stimulation electrode for use with an implantable tissue stimulator, especially a pacemaker, a defibrillator, a bone stimulator or a neurostimulator includes a metal base body, optionally one or more intermediate layers disposed on the base body and a coating covering the base body and, optionally, intermediate layers in order to increase tissue compatibility. The coating should prevent tissue irritations after implantation and more particularly increase the stimulus threshold associated therewith, have very high biocompatibility and also has an anti-inflammatory effect. An increase in tissue compatibility is achieved by virtue of the fact that the coating has a polysaccharide layer made of hyaluronic acid and/or hyaluronic acid derivatives.

摘要翻译： 用于可植入组织刺激器，特别是起搏器，除纤颤器，骨刺激器或神经刺激器的可植入刺激电极包括金属基体，可选地一个或多个设置在基体上的中间层和覆盖基体的涂层， ，任选地，中间层以增加组织相容性。 涂层应防止植入后的组织刺激，并且更特别地增加与其相关的刺激阈值，具有非常高的生物相容性并且还具有抗炎作用。 由于涂层具有由透明质酸和/或透明质酸衍生物制成的多糖层的事实，组织相容性的增加是可以实现的。

公开(公告)号：US20070026038A1

公开(公告)日：2007-02-01

申请号：US11531512

申请日：2006-09-13

申请人： Gerd Bayer ,  Markus Nagel ,  Alexander Borck

发明人： Gerd Bayer ,  Markus Nagel ,  Alexander Borck

IPC分类号： A61F2/02 ,  B05D3/00

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61L2420/02 ,  Y10S623/90 ,  Y10S623/901 ,  Y10T428/31536 ,  C08L5/08

摘要： The invention concerns methods of coating stents and stents produced in accordance therewith. The object of the invention is to provide methods of coating stents with a polysaccharide layer which has improved adhesion capacity on the substrate surface of the implant, and to afford correspondingly functionalized stents. That is achieved inter alia by covalent bonding of a non-crosslinked hyaluronic acid to a substrate surface of the stent with the formation of hyaluronic acid layer and crosslinking of the hyaluronic acid layer.

摘要翻译： 本发明涉及根据其生产的支架和支架的涂覆方法。 本发明的目的是提供用多糖层涂覆支架的方法，所述多糖层在植入物的基底表面上具有改善的粘附能力，并提供相应的功能化的支架。 这通过非交联透明质酸与透明质酸层的形成和透明质酸层的交联共价键合到支架的基底表面而实现。

公开(公告)号：US20060165962A1

公开(公告)日：2006-07-27

申请号：US10561774

申请日：2004-04-19

申请人： Alexander Borck ,  Gerd Bayer

发明人： Alexander Borck ,  Gerd Bayer

IPC分类号： B44C1/17

CPC分类号： A61L31/148 ,  A61L31/10 ,  A61L2420/08 ,  Y10T428/24802 ,  C08L5/08

摘要： The invention relates to a coating system for implants comprising a metal base body, which is optionally covered with one or several intermediate layers. Said coating system comprises a coating which is disposed thereon in order to increase tissue compatibility. The coating prevents tissue irritations after implantation has an extremely high biocompatibility and has an anti-inflammatory effect. This is achieved by virtue of the fact that the coating comprises a polysaccharide layer made of a) chitosane and b) hyaluronic acid and/or hyaluronic acid derivatives.

摘要翻译： 本发明涉及一种用于植入物的涂层系统，其包括金属基体，其任选地覆盖有一个或多个中间层。 所述涂层系统包括设置在其上的涂层，以增加组织相容性。 涂层防止植入后的组织刺激具有极高的生物相容性并具有抗炎作用。 这通过以下事实来实现：涂层包含由a）二甲硅烷和b）透明质酸和/或透明质酸衍生物制成的多糖层。

公开(公告)号：US08173196B2

公开(公告)日：2012-05-08

申请号：US11531512

申请日：2006-09-13

申请人： Gerd Bayer ,  Markus Nagel ,  Alexander Borck

发明人： Gerd Bayer ,  Markus Nagel ,  Alexander Borck

IPC分类号： A61L33/00

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61L2420/02 ,  Y10S623/90 ,  Y10S623/901 ,  Y10T428/31536 ,  C08L5/08

摘要： The invention concerns methods of coating stents and stents produced in accordance therewith. The object of the invention is to provide methods of coating stents with a polysaccharide layer which has improved adhesion capacity on the substrate surface of the implant, and to afford correspondingly functionalized stents. That is achieved inter alia by covalent bonding of a non-crosslinked hyaluronic acid to a substrate surface of the stent with the formation of hyaluronic acid layer and crosslinking of the hyaluronic acid layer.

摘要翻译： 本发明涉及根据其生产的支架和支架的涂覆方法。 本发明的目的是提供用多糖层涂覆支架的方法，所述多糖层在植入物的基底表面上具有改善的粘附能力，并提供相应的功能化的支架。 这通过非交联透明质酸与透明质酸层的形成和透明质酸层的交联共价键合到支架的基底表面而实现。

公开(公告)号：US08019848B2

公开(公告)日：2011-09-13

申请号：US12356723

申请日：2009-01-21

申请人： Gerd Bayer ,  Felix Eickhoff ,  Onur Keles ,  Frank Koeble ,  Andreas Koenig ,  Carl Mayer

发明人： Gerd Bayer ,  Felix Eickhoff ,  Onur Keles ,  Frank Koeble ,  Andreas Koenig ,  Carl Mayer

IPC分类号： G06F15/173

CPC分类号： G06F15/16

摘要： An improved method for connection exploration in a network is disclosed, wherein said network includes a plurality of network elements each including at least one port, wherein a globally unique identifier is assigned to each individual port of said network elements, and wherein connected ports of two network elements transfer their globally unique identifiers over a corresponding connection using heartbeat-ordered sequences. The method comprises capturing said transferred globally unique identifiers at receiving ports, storing each of said captured globally unique identifiers at a corresponding receiving port, reading out said transferred globally unique identifiers stored at each port of said network elements using an in-band access, matching said read out globally unique identifiers to a hardware configuration data set to identify connected network elements and connections between said connected network elements, and recording information about existing connections between said network elements.

摘要翻译： 公开了一种用于网络中的连接探索的改进方法，其中所述网络包括多个网络元件，每个网络元件包括至少一个端口，其中将全局唯一标识符分配给所述网络元件的每个单独端口，并且其中连接的两个端口 网络元素使用心跳顺序序列在相应的连接上传送其全局唯一标识符。 该方法包括：在接收端口捕获所述传输的全球唯一标识符，将每个所述捕获的全局唯一标识符存储在相应的接收端口，使用带内接入，匹配来读出存储在所述网络元件的每个端口处的所述传输的全球唯一标识符 将所述全局唯一标识符读出到硬件配置数据集以识别所连接的网络元件之间的连接的网络元件和连接，以及记录关于所述网络元件之间的现有连接的信息。

公开(公告)号：US20120272037A1

公开(公告)日：2012-10-25

申请号：US13452860

申请日：2012-04-21

申请人： Gerd Bayer ,  Hannes Hering ,  Hoang-Nam Nguyen ,  Christoph Raisch ,  Jan-Bernd Themann

发明人： Gerd Bayer ,  Hannes Hering ,  Hoang-Nam Nguyen ,  Christoph Raisch ,  Jan-Bernd Themann

IPC分类号： G06F12/06

CPC分类号： G06F13/404 ,  G06F12/0292 ,  G06F12/1081 ,  G06F13/4072 ,  G06F13/4282 ,  G06F2212/656

摘要： A data processing system includes a main storage, an input/output memory management unit (IOMMU) coupled to the main storage, a peripheral component interconnect (PCI) device coupled to the IOMMU, and a mapper. The system is configured to allocate an amount of physical memory in the main storage and the IOMMU is configured to provide access to the main storage and to map a PCI address from the PCI device to a physical memory address within the main storage. The mapper is configured to perform a mapping between the allocated amount of physical memory of the main storage and a contiguous PCI address space. The IOMMU is further configured to translate PCI addresses of the contiguous PCI address space to the physical memory address within the main storage.

摘要翻译： 数据处理系统包括主存储器，耦合到主存储器的输入/输出存储器管理单元（IOMMU），耦合到IOMMU的外围组件互连（PCI）设备和映射器。 该系统被配置为在主存储器中分配一定量的物理存储器，并且IOMMU被配置为提供对主存储器的访问并且将PCI地址从PCI设备映射到主存储器内的物理存储器地址。 映射器被配置为执行主存储器的物理存储器的分配量与连续的PCI地址空间之间的映射。 IOMMU还被配置为将连续PCI地址空间的PCI地址转换为主存储器内的物理存储器地址。

公开(公告)号：US20090198810A1

公开(公告)日：2009-08-06

申请号：US12356723

申请日：2009-01-21

申请人： Gerd Bayer ,  Felix Eickhoff ,  Onur Keles ,  Frank Koeble ,  Andreas Koenig ,  Carl Mayer

发明人： Gerd Bayer ,  Felix Eickhoff ,  Onur Keles ,  Frank Koeble ,  Andreas Koenig ,  Carl Mayer

IPC分类号： G06F15/16

CPC分类号： G06F15/16

摘要： An improved method for connection exploration in a network is disclosed, wherein said network includes a plurality of network elements each including at least one port, wherein a globally unique identifier is assigned to each individual port of said network elements, and wherein connected ports of two network elements transfer their globally unique identifiers over a corresponding connection using heartbeat-ordered sequences. The method comprises capturing said transferred globally unique identifiers at receiving ports, storing each of said captured globally unique identifiers at a corresponding receiving port, reading out said transferred globally unique identifiers stored at each port of said network elements using an in-band access, matching said read out globally unique identifiers to a hardware configuration data set to identify connected network elements and connections between said connected network elements, and recording information about existing connections between said network elements.

摘要翻译： 公开了一种用于网络中的连接探索的改进方法，其中所述网络包括多个网络元件，每个网络元件包括至少一个端口，其中将全局唯一标识符分配给所述网络元件的每个单独端口，并且其中连接的两个端口 网络元素使用心跳顺序序列在相应的连接上传送其全局唯一标识符。 该方法包括：在接收端口捕获所述传输的全球唯一标识符，将每个所述捕获的全局唯一标识符存储在相应的接收端口，使用带内接入，匹配来读出存储在所述网络元件的每个端口处的所述传输的全球唯一标识符 将所述全局唯一标识符读出到硬件配置数据集以识别所连接的网络元件之间的连接的网络元件和连接，以及记录关于所述网络元件之间的现有连接的信息。

公开(公告)号：US09355031B2

公开(公告)日：2016-05-31

申请号：US13452860

申请日：2012-04-21

申请人： Gerd Bayer ,  Hannes Hering ,  Hoang-Nam Nguyen ,  Christoph Raisch ,  Jan-Bernd Themann

发明人： Gerd Bayer ,  Hannes Hering ,  Hoang-Nam Nguyen ,  Christoph Raisch ,  Jan-Bernd Themann

IPC分类号： G06F12/00 ,  G06F12/02 ,  G06F12/10

CPC分类号： G06F13/404 ,  G06F12/0292 ,  G06F12/1081 ,  G06F13/4072 ,  G06F13/4282 ,  G06F2212/656

摘要： A data processing system includes a main storage, an input/output memory management unit (IOMMU) coupled to the main storage, a peripheral component interconnect (PCI) device coupled to the IOMMU, and a mapper. The system is configured to allocate an amount of physical memory in the main storage and the IOMMU is configured to provide access to the main storage and to map a PCI address from the PCI device to a physical memory address within the main storage. The mapper is configured to perform a mapping between the allocated amount of physical memory of the main storage and a contiguous PCI address space. The IOMMU is further configured to translate PCI addresses of the contiguous PCI address space to the physical memory address within the main storage.

摘要翻译： 数据处理系统包括主存储器，耦合到主存储器的输入/输出存储器管理单元（IOMMU），耦合到IOMMU的外围组件互连（PCI）设备和映射器。 该系统被配置为在主存储器中分配一定量的物理存储器，并且IOMMU被配置为提供对主存储器的访问并且将PCI地址从PCI设备映射到主存储器内的物理存储器地址。 映射器被配置为执行主存储器的物理存储器的分配量与连续的PCI地址空间之间的映射。 IOMMU还被配置为将连续PCI地址空间的PCI地址转换为主存储器内的物理存储器地址。

公开(公告)号：US08799592B2

公开(公告)日：2014-08-05

申请号：US13442904

申请日：2012-04-10

申请人： Gerd Bayer ,  Marco Kraemer ,  Hoang-Nam Nguyen ,  Christoph Raisch ,  Stefan Usenbinz

发明人： Gerd Bayer ,  Marco Kraemer ,  Hoang-Nam Nguyen ,  Christoph Raisch ,  Stefan Usenbinz

IPC分类号： G06F12/00 ,  G06F3/06 ,  G06F12/08 ,  G06F13/12

CPC分类号： G06F3/0664 ,  G06F9/45545 ,  G06F9/544 ,  G06F12/0835 ,  G06F12/1081 ,  G06F12/1441 ,  G06F13/122 ,  G06F15/17331 ,  G06F2009/45579 ,  G06F2212/151

摘要： A computer system with a memory containing a first guest operating system, including a first portion of the memory and a second guest operating system, including a second portion of the memory. The memory further contains an address exchange module for exchanging memory address handles, a data mover for moving data between the first and second portions of the memory, and an emulated input output memory management unit for controlling the data mover. Instructions in the memory cause the processor to: register accessible memory with the emulated input output memory management unit, write address handles to the address exchange module, read the address handles from the address exchange module, and move the data into the second portion of the memory.

摘要翻译： 一种具有包含第一客户机操作系统的存储器的计算机系统，包括存储器的第一部分和包括存储器的第二部分的第二客户机操作系统。 存储器还包括用于交换存储器地址句柄的地址交换模块，用于在存储器的第一和第二部分之间移动数据的数据移动器，以及用于控制数据移动器的仿真输入输出存储器管理单元。 存储器中的指令会导致处理器：使用仿真的输入输出存储器管理单元注册可访问存储器，将地址处理写入地址交换模块，从地址交换模块读取地址句柄，并将数据移入第二部分 记忆。