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18 条记录 (耗时 0.029 秒)

    Delivery of superoxide dismutase to neuronal cells
    2.
    发明申请
    Delivery of superoxide dismutase to neuronal cells 失效
    将超氧化物歧化酶递送至神经元细胞

    公开(公告)号：US20050255093A1

    公开(公告)日：2005-11-17

    申请号：US11062471

    申请日：2005-02-22

    申请人： Clifford Shone ,  John Sutton ,  Bassam Hallis ,  Nigel Silman

    发明人： Clifford Shone ,  John Sutton ,  Bassam Hallis ,  Nigel Silman

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/44 ,  A61K47/48 ,  A61K48/00 ,  A61P25/28 ,  A61P39/06 ,  C07K14/33 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12N15/53 ,  A61K39/08

    CPC分类号： C12N9/0089 ,  A61K38/00 ,  A61K47/6415 ,  A61K48/00 ,  C07K14/33 ,  C07K2319/00

    摘要： A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dimutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dimutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cells and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondira.

    摘要翻译： 用于将超氧化物歧化酶递送至神经元细胞的组合物包含通过接头与神经元细胞靶向组分连接的超氧化物歧化酶，该组分包含结合神经元细胞的第一结构域和将超氧化物二聚体转位到神经细胞中的第二结构域 。 易位后，切割接头以从神经元细胞靶向结构域释放超氧化物歧化酶。 还描述了用于治疗对神经元细胞的氧化损伤的组合物的使用，并且使用人线粒体前导序列进一步靶向组合物。 描述了含有细菌超氧化物歧化酶加上靶向人线粒体的序列的杂合多肽。

    Method for generating and using a transformer model
    3.
    发明申请
    Method for generating and using a transformer model 审中-公开
    用于生成和使用变压器模型的方法

    公开(公告)号：US20050096886A1

    公开(公告)日：2005-05-05

    申请号：US10699217

    申请日：2003-10-31

    申请人： Karen Smiley ,  John Sutton ,  Thomas Long ,  David Cox

    发明人： Karen Smiley ,  John Sutton ,  Thomas Long ,  David Cox

    IPC分类号： G06F20060101 ,  G06F17/10 ,  G06F17/50

    CPC分类号： G06F17/5036

    摘要： A preferred method for generating a transformer model includes defining a data base by selecting a first and a second set of parameters for inclusion in the data base, the first set of parameters being representative of at least one of as-designed and as-built transformer data, the second set of parameters being representative of transformer performance data. The preferred method also includes storing data from a plurality of transformers in the data base, the data from a plurality of transformers corresponding to the first and second sets of parameters. The preferred method further includes determining interrelationships between the first and second sets of parameters by analyzing the data from a plurality of transformers using multivariate statistical analysis.

    摘要翻译： 用于生成变压器模型的优选方法包括通过选择用于包含在数据库中的第一和第二组参数来定义数据库，第一组参数表示至少一个设计和构建的变压器 数据，第二组参数代表变压器性能数据。 优选方法还包括从数据库中的多个变压器存储来自与第一和第二组参数对应的多个变压器的数据。 优选方法还包括通过使用多变量统计分析分析来自多个变压器的数据来确定第一组参数和第二组参数之间的相互关系。

    Method and apparatus for testing laminated cores of electrical machines
    6.
    发明授权
    Method and apparatus for testing laminated cores of electrical machines 失效
    电机层压铁芯测试方法及装置

    公开(公告)号：US06903556B2

    公开(公告)日：2005-06-07

    申请号：US10308895

    申请日：2002-12-03

    申请人： John Sutton

    发明人： John Sutton

    IPC分类号： G01R31/34 ,  G01R31/06 ,  G01B7/06

    CPC分类号： G01R31/343

    摘要： There is provided an apparatus and associated method for the testing of a laminated core (100) for an electrical machine. The apparatus supplies an excitation signal to the winding (102) of the electrical machine which is of a frequency higher than the rated operating frequency of the machine. There is also provided a phase sensitive detector (110) which receives, from the laminated core (100), a signal in response to the excitation signal. The phase sensitive detector (110) resolves the received signal into a number of components. These components are resolved relative to a reference signal. The size of the components determines the severity of any fault that exists within the laminated core (100.

    摘要翻译： 提供了一种用于电机的层叠铁芯（100）的测试的装置和相关方法。 该装置向电机的绕组（102）提供激励信号，其频率高于机器的额定工作频率。 还提供了一种相敏检测器（110），其从叠层铁心（100）接收响应于激励信号的信号。 相位敏感检测器（110）将接收到的信号解析为多个分量。 这些组件相对于参考信号被解析。 组件的尺寸决定了层叠铁心内存在的任何故障的严重性（100。

    Portable pen-based computer with vehicular docking station
    8.
    发明授权
    Portable pen-based computer with vehicular docking station 有权
    便携式笔式电脑带车载坞站

    公开(公告)号：US06426872B1

    公开(公告)日：2002-07-30

    申请号：US09200805

    申请日：1998-11-27

    申请人： John Sutton ,  Danile Swindler ,  Brian Groh ,  Richard Perley ,  Glen Clifton

    发明人： John Sutton ,  Danile Swindler ,  Brian Groh ,  Richard Perley ,  Glen Clifton

    IPC分类号： H05K710

    CPC分类号： G06F1/1656 ,  B60R11/0252 ,  B60R2011/0073 ,  G06F1/1626 ,  G06F1/1632

    摘要： A pen-based portable computer, or pen-tablet computer, for use with a vehicular docking station that allows for the exchange or replacement of components thereof without the need for returning the computer to the manufacturer. The computer utilizes a main or primary housing for the major components of the computer, and a separate, independent, auxiliary expansion unit having its own housing for mounting a replaceable radio module that is connected to the main computer via a multi-pin connector, whereby the replacement or exchange of the radio module for a different one is easily and readily achieved, and where auxiliary or expansion devices may be connected to the main computer thereby, and where the auxiliary device itself serves as a handle for holding the main computer. Also provided is a vehicular docking station for the combined main computer and auxiliary unit, which vehicular docking station is provided with a multi-pin connector for receiving thereby a multi-pin connector of the auxiliary unit when the computer is connected to the auxiliary unit.

    摘要翻译： 一种用于与车辆对接站一起使用的笔式便携式计算机或笔式计算机，其允许其组件的更换或更换，而不需要将计算机返回给制造商。 该计算机利用主计算机的主要部件或主要部件，以及独立的独立的辅助扩展单元，其具有用于安装可更换的无线电模块的外壳，该可替换无线电模块通过多针连接器连接到主计算机，由此 对于不同的无线电模块的更换或更换是容易且容易实现的，并且辅助设备或扩展设备可以由此连接到主计算机，并且辅助设备本身用作用于保持主计算机的手柄。 还提供了用于组合的主计算机和辅助单元的车辆对接站，其中车辆对接站设置有多针连接器，用于当计算机连接到辅助单元时从其接收辅助单元的多针连接器。

    Magnetic ore separator
    9.
    发明授权
    Magnetic ore separator 失效
    磁选矿机

    公开(公告)号：US3966590A

    公开(公告)日：1976-06-29

    申请号：US508013

    申请日：1974-09-20

    申请人： Roger W. Boom ,  Yehia M. Eyssa ,  John Sutton

    发明人： Roger W. Boom ,  Yehia M. Eyssa ,  John Sutton

    IPC分类号： B03C1/035 ,  B03C1/30

    CPC分类号： B03C1/035 ,  Y10S505/933

    摘要： A radial magnetic field gradient applied from an elongated central source is traversed parallel to the elongation by a turbulent flow of a slurried mixture of magnetic and nonmagnetic components in the presence of a force thereon opposing in direction the attractive force of the magnetic field upon the magnetic components whereby the respective components are separated by the disparate forces and the flow acts to continuously advance the separation and direct separated components toward related collecting stations.

    摘要翻译： 从细长的中心源施加的径向磁场梯度在磁力和非磁性部件的浆液混合物的湍流下平行于伸长方向穿过，其中力在其上相对于磁场的吸引力在磁体上的力 各部件通过不同的力分离的部件，并且该流动用于将分离和直接分离的部件连续推进到相关的收集站。

    Sweatband and sun protective headgear apparatus
    10.
    发明申请
    Sweatband and sun protective headgear apparatus 审中-公开
    汗水带和防晒头盔装置

    公开(公告)号：US20100011488A1

    公开(公告)日：2010-01-21

    申请号：US12220004

    申请日：2008-07-21

    申请人： John Sutton

    发明人： John Sutton

    IPC分类号： A42B3/00 ,  A42B1/24 ,  A42C5/02 ,  A42B1/00

    CPC分类号： A42C5/02 ,  A42B1/067

    摘要： A headgear (10) has a sweatband (12) has a sheet material (18) attached thereto for extending over a person's head and down the back of a person's neck.

    摘要翻译： 头带（10）具有汗带（12），其具有附接到其上的片材（18），用于在人的头部上延伸并且向下延伸到人的颈部的后部。