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公开(公告)号：US11667947B2
公开(公告)日：2023-06-06
申请号：US16704052
申请日：2019-12-05
Applicant: Colgate-Palmolive Company
Inventor： Ekta Makwana , Carlo Daep
Abstract: Described herein are methods and systems for identifying a composition having anti-pathogenic activity; evaluating the anti-pathogenic activity of a composition; measuring the metabolic function of a pathogen; and/or comparing the anti-pathogenic performance of a plurality of compositions.
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公开(公告)号：US11103209B2
公开(公告)日：2021-08-31
申请号：US16186639
申请日：2018-11-12
Applicant: Colgate-Palmolive Company
Inventor： Xiaonan Zhang , Alan Sorrentino , Carlo Daep , Zi Wu
Abstract: An ultrasonic system may include: an oral care device including: a head; a plurality of teeth cleaning elements extending from a first side of the head; and an ultrasound module including an ultrasound transceiver positioned in the head, the ultrasound transceiver configured to produce an ultrasound signal on the first side of the head and to generate a detection signal from a reflected ultrasound signal; and a processing module operably coupled to the ultrasound module to receive the detection signal; wherein the processing module includes a programmable processor configured to process the detection signal non-linearly with respect to time by first identifying a first reflection representing a surface of a tooth and then determining whether a second reflection peak is present in the detection signal at a time prior to the first reflection peak, the second reflection peak representing a biofilm on the surface of the tooth.
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公开(公告)号：US10959932B2
公开(公告)日：2021-03-30
申请号：US16067014
申请日：2016-12-30
Applicant: Colgate-Palmolive Company
Inventor： Carlo Daep , Michael Fitzgerald , Ekta Makwana , Peter R. Hilliard, Jr. , Shamim Ansari , Robert D'Ambrogio
IPC: A61K8/64 , C01B33/149 , A61Q11/00 , A61K8/02 , A61K9/00 , A61K8/44 , A61K8/25 , A61K6/54 , A61K47/60 , A61K8/21 , A61K8/27 , A61K38/17 , A61K9/16
Abstract: Disclosed herein is mucin-coated silica, compositions comprising the same, and methods of promoting the aggregation and/or clearance of oral bacteria using such compositions.
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Patent Agency Ranking
4.发明授权公开(公告)号：US12203926B2
公开(公告)日：2025-01-21
申请号：US17309896
申请日：2019-12-17
Applicant: Colgate-Palmolive Company
Inventor： Camille Zenobia , Harsh Mahendra Trivedi , Ying Yang , Carlo Daep , James Masters
Abstract: An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.
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公开(公告)号：US11490623B2
公开(公告)日：2022-11-08
申请号：US16846770
申请日：2020-04-13
Inventor： Carl Myers , Carlo Daep , Lynette Zaidel , James Masters , Russell Composto , Hyun-Su Lee
IPC: A01N47/44 , C11D3/37 , A61K31/785 , A61Q17/00 , C11D3/48 , A61Q11/00 , C08F126/02 , A61K8/91 , A01N25/08 , A61K8/81 , C08F8/30 , C09D5/14 , C09D139/00
Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.
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公开(公告)号：US11931443B2
公开(公告)日：2024-03-19
申请号：US17214731
申请日：2021-03-26
Applicant: Colgate-Palmolive Company
Inventor： Carlo Daep , Harsh Mahendra Trivedi , Paul Thomson
Abstract: This invention relates to oral care compositions comprising guanidine, zinc citrate and zinc oxide, and a fluoride source, as well as to methods of using and of making these compositions.
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公开(公告)号：US20220357268A1
公开(公告)日：2022-11-10
申请号：US17250473
申请日：2020-10-29
Inventor： Carlo Daep , Deon HINES , Harsh Mahendra TRIVEDI , James MASTERS , LaTonya KILPATRICK-LIVERMAN , Luciana RINAUDI MARRON , Lynette ZAIDEL , Alexander H. RICKARD , Derek S. SAMARIAN , Gregory KRUSE
Abstract: A system for testing biological samples includes a frame having first and second sides and an aperture extending through the frame from the first side to the second side. First and second covers are attached to the first and second sides of the frame to form a well bounded by the frame, the first cover, and the second cover. An electromagnetic imaging device is used to image the biological sample through the first cover. A method is also conceived, wherein a first fluid is supplied to the well, the first fluid including live cells. A biofilm is grown from the live cells. A second fluid is supplied to the well and the biofilm is imaged using the electromagnetic imaging device.
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公开(公告)号：US10653149B2
公开(公告)日：2020-05-19
申请号：US15788852
申请日：2017-10-20
Inventor： Carl Myers , Carlo Daep , Lynette Zaidel , James Masters , Russell Composto , Hyun-Su Lee
IPC: A61K31/785 , A61Q11/00 , C08F126/02 , A01N47/44 , C11D3/37 , A61Q17/00 , C11D3/48 , A61K8/81 , C08F8/30 , C09D5/14 , C09D139/00 , A61K8/91 , A01N25/08
Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.
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