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公开(公告)号：US10988501B2
公开(公告)日：2021-04-27
申请号：US16094845
申请日：2017-04-21
Applicant: Complete Genomics, Inc. , BGI Shenzhen
Inventor： Handong Li , Snezana Drmanac , Radoje Drmanac , Xun Xu , Lingling Peng , Scott Gablenz
IPC: C07H19/10 , C07H19/20 , C07H15/04 , C12Q1/6869 , C07H21/04
Abstract: Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.
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公开(公告)号：US20170240961A1
公开(公告)日：2017-08-24
申请号：US15440920
申请日：2017-02-23
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Snezana Drmanac , Handong Li , Xun Xu
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C07H21/04 , C12Q1/6876 , C12Q2535/113 , C12Q2563/107 , C12Q2563/131
Abstract: Nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.
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Patent Agency Ranking
公开(公告)号：US11485966B2
公开(公告)日：2022-11-01
申请号：US16754713
申请日：2017-10-11
Applicant: MGI TECH CO., LTD. , COMPLETE GENOMICS, INC.
Inventor： Hui Wang , Xun Xu , Jin Yang , Ao Chen , Chongjun Xu , Wenwei Zhang
Abstract: The present invention provides a method for improving the loading of nucleic acid on a solid support by contacting the solid support with a poloxamer-containing reagent. The present invention also provides a method for improving the stability of a nucleic acid on a solid support, comprising contacting a nucleic acid molecule with a partially double-strand oligonucleotide before or after loading the nucleic acid molecule on a solid support, so as to cause the nucleic acid molecule to hybridize with the oligonucleotide. The present invention also provides a combined use of the two methods.
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公开(公告)号：US20180223358A1
公开(公告)日：2018-08-09
申请号：US15862566
申请日：2018-01-04
Applicant: Complete Genomics, Inc. , BGI Shenzhen
Inventor： Radoje Drmanac , Snezana Drmanac , Handong Li , Xun Xu , Matthew J. Callow , Leon Eckhardt , Naibo Yang , Quan Ding
IPC: C12Q1/6874 , C12Q1/6876
CPC classification number: C12Q1/6874 , A61K47/00 , C07K16/2851 , C07K16/44 , C07K2317/73 , C12Q1/6804 , C12Q1/6869 , C12Q1/6876 , C12Q2525/186
Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
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公开(公告)号：US20230272467A1
公开(公告)日：2023-08-31
申请号：US18144121
申请日：2023-05-05
Applicant: MGI TECH CO., LTD. , COMPLETE GENOMICS, INC.
Inventor： Jin Yang , Xun Xu , Hui Wang , Bin Xie , Zhuokun Li , Shengming Zhao , Ao Chen , Chongjun Xu , Wenwei Zhang , Ming Ni
IPC: C12Q1/6869 , C12Q1/6876 , G01N21/64
CPC classification number: C12Q1/6869 , C12Q1/6876 , G01N21/6486 , B01L2200/10
Abstract: The present invention provides a method for sequencing a nucleic acid using an immersion reaction protocol. The immersion reaction protocol comprises sequentially immersing a solid support having nucleic acid molecules immobilized thereon in different reaction containers to realize nucleic acid sequencing.
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公开(公告)号：US11692221B2
公开(公告)日：2023-07-04
申请号：US16635131
申请日：2017-08-01
Applicant: MGI TECH CO., LTD. , COMPLETE GENOMICS, INC.
Inventor： Jin Yang , Xun Xu , Hui Wang , Bin Xie , Zhuokun Li , Shengming Zhao , Ao Chen , Chongjun Xu , Wenwei Zhang , Ming Ni
IPC: C12Q1/6869 , C12Q1/6876 , G01N21/64
CPC classification number: C12Q1/6869 , C12Q1/6876 , G01N21/6486 , B01L2200/10
Abstract: The present invention provides a method for sequencing a nucleic acid using an immersion reaction protocol. The immersion reaction protocol comprises sequentially immersing a solid support having nucleic acid molecules immobilized thereon in different reaction containers to realize nucleic acid sequencing.
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公开(公告)号：US20190144482A1
公开(公告)日：2019-05-16
申请号：US16094845
申请日：2017-04-21
Applicant: Complete Genomics, Inc. , BGI Shenzhen
Inventor： Handong Li , Snezana Drmanac , Radoje Drmanac , Xun Xu , Lingling Peng , Scott Gablenz
IPC: C07H15/04 , C07H19/10 , C07H21/04 , C07H19/20 , C12Q1/6869
Abstract: Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.
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