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1.发明申请METHOD AND DEVICE FOR INTEGRATED SYNTHESIS AND ANALYSIS OF ANALYTES ON A SUPPORT 审中-公开一体化合成方法与装置及分析仪在支持下的分析公开(公告)号：US20090156423A1
公开(公告)日：2009-06-18
申请号：US12333417
申请日：2008-12-12
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00279 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/0054 , B01J2219/0059 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N33/54373
摘要： Methods and devices provide integrated synthesis of a support for analyte determination and the analyte determination. Preferred embodiments involve particles immobilized on the surface of a support to which receptors are coupled location-specifically, time-specifically or both on pre-determined positions on the support.
摘要翻译： 方法和装置提供了用于分析物测定和分析物测定的支持物的综合合成。 优选的实施方案涉及固定在载体表面上的颗粒，其中受体在载体上的预定位置上位置特异性地，时间特异性地或偶合地偶合。
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2.发明授权Method and device for the integrated synthesis and analysis of analytes on a support 失效用于综合合成和分析支持物上分析物的方法和装置公开(公告)号：US07470540B2
公开(公告)日：2008-12-30
申请号：US10399450
申请日：2001-10-17
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00279 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/0054 , B01J2219/0059 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N33/54373 , Y10T436/11 , Y10T436/117497 , Y10T436/163333 , Y10T436/25375 , Y10T436/255
摘要： A method for preparing receptor-coated particles is described which comprises the following steps: a) providing a support body, b) conducting a liquid containing particles into or onto the support body, c) immobilizing the particles on at least one surface area of the support body, d) conducting a liquid which contains receptors or receptor building blocks for synthesizing polymeric receptors over the immobilized particles, e) coupling the receptors or receptor building blocks location—or/and time-specifically to the immobilized particles at in each case predetermined positions of the support body, f) repeating, where appropriate, the steps (d) and (e), until the desired receptors have been synthesized on the immobilized particles at the in each case predetermined positions of the support body.
摘要翻译： 描述了制备受体包被的颗粒的方法，其包括以下步骤：a）提供支撑体，b）将含有颗粒的液体导入载体上或载体上，c）将颗粒固定在至少一个表面区域上 支持体，d）导入含有用于在固定化颗粒上合成聚合物受体的受体或受体结构单元的液体，e）将受体或受体结构单元位置或/和/和时间特异性偶联至固定化颗粒，在每种情况下预定 支撑体的位置，f）在适当的情况下重复步骤（d）和（e），直到在固定化颗粒上合成所需的受体，在每种情况下在支撑体的预定位置。
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3.发明申请Photoactivatable two-stage protective groups for the synthesis of biopolymers 失效用于合成生物聚合物的可光活化的两阶段保护基团公开(公告)号：US20060111564A1
公开(公告)日：2006-05-25
申请号：US10540396
申请日：2003-12-23
申请人： Ramon Guimil , Matthias Scheffler , Barbro Beijer
发明人： Ramon Guimil , Matthias Scheffler , Barbro Beijer
IPC分类号： C07H21/04
CPC分类号： B01J19/0046 , B01J2219/00576 , B01J2219/00596 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B50/18
摘要： The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.
摘要翻译： 本发明涉及通过从承载两级保护基的保护合成结构单元逐步组装合成生物聚合物的方法。 两级保护基团通过第一照射步骤活化，并通过随后的化学处理步骤消除。 使用通过分子内三重态敏化剂显着加速激活过程或/具有荧光性质的光活化组分。 两级保护组特别可以在质量控制的框架内使用。
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公开(公告)号：US20060154253A1
公开(公告)日：2006-07-13
申请号：US10540517
申请日：2003-12-23
申请人： Ramon Guimil , Matthias Scheffler , Barbro Beijer
发明人： Ramon Guimil , Matthias Scheffler , Barbro Beijer
IPC分类号： C12Q1/68 , C07F3/08 , C07D311/88 , C07D311/02
CPC分类号： C07C205/34 , C07D231/12 , C07D233/56 , C07D249/08 , C07H15/26 , C07H19/00 , C07H21/00 , Y02P20/55
摘要： The present invention relates to a method for validating the synthesis of arrays, in particular of biopolymers, by step-by-step construction from protected and labeled synthesis building blocks.
摘要翻译： 本发明涉及通过从受保护和标记的合成结构单元的逐步构建来验证阵列的合成，特别是生物聚合物的合成方法。
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公开(公告)号：US20120309645A1
公开(公告)日：2012-12-06
申请号：US13577335
申请日：2011-02-07
申请人： Andreas Keller , Matthias Scheffler , Markus Beier
发明人： Andreas Keller , Matthias Scheffler , Markus Beier
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/178
摘要： The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
摘要翻译： 本发明提供了基于在不同条件下具有改变的表达水平的特异性miRNA的测定来诊断健康状况的新方法，例如， 疾病状态与健康对照相比。
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6.发明授权Photoactivatable two-stage protective groups for the synthesis of biopolymers 失效用于合成生物聚合物的可光活化的两阶段保护基团公开(公告)号：US07737089B2
公开(公告)日：2010-06-15
申请号：US10540396
申请日：2003-12-23
申请人： Ramon Güimil , Matthias Scheffler , Barbro Beijer
发明人： Ramon Güimil , Matthias Scheffler , Barbro Beijer
IPC分类号： C40B70/00
CPC分类号： B01J19/0046 , B01J2219/00576 , B01J2219/00596 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B50/18
摘要： The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.
摘要翻译： 本发明涉及通过从承载两级保护基的保护合成结构单元逐步组装合成生物聚合物的方法。 两级保护基团通过第一照射步骤活化，并通过随后的化学处理步骤消除。 使用通过分子内三重态敏化剂显着加速激活过程或/具有荧光性质的光活化组分。 两级保护组特别可以在质量控制的框架内使用。
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公开(公告)号：US07355036B2
公开(公告)日：2008-04-08
申请号：US10482744
申请日：2002-07-03
IPC分类号： C07H21/04
摘要： The invention relates to a method for the synthesis of a nucleic acid by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups. The two-stage protective groups are split by means of a first exposure step and a subsequent chemical treatment step
摘要翻译： 本发明涉及通过从承载两阶段保护基团的保护合成结构单元逐渐分解来合成核酸的方法。 通过第一曝光步骤和随后的化学处理步骤将两级保护基分开
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公开(公告)号：US09822416B2
公开(公告)日：2017-11-21
申请号：US13577335
申请日：2011-02-07
申请人： Andreas Keller , Matthias Scheffler , Markus Beier
发明人： Andreas Keller , Matthias Scheffler , Markus Beier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/178
摘要： The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
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公开(公告)号：US20060292612A1
公开(公告)日：2006-12-28
申请号：US11452422
申请日：2006-06-14
申请人： Matthias Scheffler
发明人： Matthias Scheffler
CPC分类号： G01N33/5436 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/00675 , B01J2219/00693 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B82Y30/00 , G01N33/532 , G01N33/58
摘要： The invention relates to a method which can be used to test firstly a reaction and secondly the distribution of functional groups on a surface. This method is employed in a situation that demands documentation or testing of a distribution of surface functionalization, which is as homogeneous as possible.
摘要翻译： 本发明涉及一种可用于首先测试反应的方法，其次涉及表面上官能团的分布。 这种方法用于需要文件化或测试表面功能化分布的情况，尽可能均匀。
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